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Indian Journal of Dermatology, Venereology and Leprology
Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)
ISSN: 0378-6323 EISSN: 0973-3922
Vol. 69, Num. 4, 2003, pp. 314
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Indian Journal of Dermatology, Venereology & Leprology, Vol. 69, No.
4, July-August, 2003, pp. 314
Letter to the Editor
Treatment of pemphigus
Rmaji Gupta , Sameer Gupta
M-54, Lajpat Nagar II, New Delhi - 110024
Correspondence Address: M-54, Lajpat Nagar
II, New Delhi - 110024
dr_ramji@yahoo.com
Code Number: dv03046
Sir,
It was interesting to read the article by Balachandran.[1] I
wish to point out certain discrepancies.
- There are only 25 references mentioned in the reference section while
26 are quoted in the text. The references in the text should have been 6
to 25
instead of 7 to 26.
- After successful treatment of Reiter's disease with dexamethasone
pulse,[2] we
started using dexamethasone-cyclophosphamide pulse (DCP) therapy for treating
pemphigus since 1982[3] and not since1992
as quoted. Subsequently many more reports were published in different journal. [4],[5],[6]
- The transfusion duration is 1-1.5 hours instead of 3-4 hours. The second
phase of therapy is now modified to 9 pulses in place of 6. Similarly the
third phase is of 9 months in place of 1 year.
- Among the side effects quoted, viz. infection leading to septicaemia,
I wish to clarify that infection does not lead to septicemia if appropriate
antibiotic
therapy is instituted prior to or even during the pulse therapy.
- Most of the reports by Indian workers published in our journal have
not been reviewed.
REFERENCES
| 1. |
Balachandran C. Treatment of pemphigus. Indian J Dermatol Venereol Leprol
2003;69:3-5. Back to cited text no. 1 |
| 2. |
Pasricha JS, Gupta R. Pulse therapy with dexamethasone in Reiter's disease.
Indian J Dermatol Venereol Leprol 1982;48:358-361. Back to cited text no. 2 |
| 3. |
Pasricha JS, Gupta R. Pulse therapy with dexamethasone-cyclophosphamide
in pemphigus. Indian J Dermatol Venereol Leprol 1984;50:199-203. Back to cited text no. 3 |
| 4. |
Pasricha JS, Thanzama J, Khan UK. Intermittent high dose dexamethasone-cyclophosphamide
pulse therapy for pemphigus. Br J Dermatol 1988;119:73-77. Back to cited text no. 4 |
| 5. |
Pasricha JS, Seetharam KA, Das U. Further studies on pemphigus patients
treated with dexamethasone-cyclophosphamide pulse therapy. Ind J Dermatol
Venereol Leprol 1989;55:98-104. Back to cited text no. 5 |
| 6. |
Pasricha JS, Das SS. Curative effect of dexamethasone-cyclophosphamide
pulse therapy for the treatment of pemphigus vulgaris. Int J Dermatol 1992;31:875-877. Back to cited text no. 6 |
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