Indian Journal of Dermatology, Venereology and Leprology Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL) ISSN: 0378-6323 EISSN: 0973-3922 Vol. 69, Num. 5, 2003, pp. 363-364

Indian Journal of Dermatology, Venerelogy & Leprology, Vol 69, No. 5 ,Sept-Oct, 2003, pp. 363-364

Letters to Editor

Response by the authors

Smita Prabhu, S. D. Shenoi

Deartment of Skin & STD, Kasturba Medical College & Hospital, Manipal, India.

Code Number: dv03066

Sir,

We wish to thank Dr M. J. Cyriac for spotting the error and enlightening the readers about the interaction of cyclosporin with grapefruit and not grape juice. We are happy that our article has been thoroughly scrutinized.

A point to be noted is that although sweet orange juice is safe, a variety of sour oranges used in marmalades called Seville oranges contain 6,7 dihydroxybergamottin, the furanocoumarin compound found in grapefruit. However a recent study¹ has not found interaction of Seville orange juice with cyclosporine.

Reference

1. Edwards DJ, Fitzsimmons ME, Schuetz EG et al. 6, 7 dihydroxybergamottin in grapefruit juice and Seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4 and P-glycoprotein. Clin Pharmacol Ther 1999;65: 237-44.

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