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Indian Journal of Dermatology, Venereology and Leprology
Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)
ISSN: 0378-6323 EISSN: 0973-3922
Vol. 70, Num. 1, 2004, pp. 54-56

Indian Journal of Dermatology, Venereology, Leprology, Vol. 70, No. 1, January-February, 2004, pp. 54-56

Table

Drug interactions of some commonly used drugs in dermatology

Department of Dermatology and Venereology, Medical College, Kottayam
Correspondence Address:Department of Dermatology and Venereology, Medical College, Kottayam drmjcyriac@hotmail.com

Code Number: dv04018

Drug interactions leading to serious adverse effects are to be cautiously watched for when multiple drugs are used simultaneously.[1] It is important for the physician to be aware of these interactions. Although in many instances the adverse interaction does not reach a magnitude of recognizable clinical expression, rarely it can result in a serious adverse outcome.

Adverse drug interactions may lead to increased toxicity, decreased efficacy or both. The possibility of interaction with non-prescription drugs, herbal or alternative medicines or food should also be borne in mind.[2] Increased risk of drug induced toxicity or therapeutic failure can occur when a new drug is added to a treatment regimen. It is impossible to remember all possible drug interactions. A ready to refer checklist is useful as a handy reference.

Some of the commonly used drugs in dermatology and their interactions, resultant clinical effect and possible underlying mechanisms are given in [Table - 1], [Table:1contd]. [Table - 2] lists the drugs with their relative risk for inducing interactions.

REFERENCES

  1. Shapiro LE, Shear NH. Drug interactions. In: Wolverton SE, editor. Comprehensive dermatologic drug therapy. Philadelphia: WB Saunders; 2001; p. 848-71.
  2. Prabhu S, Shenoi SD. Drugs in dermatological practice: Relationship to food. Indian J Dermatol Venereol Leprol 2003; 69: 305-6.
  3. Archer GL, Polk RE. Approach to therpay for bacterial diseases. In: Braunwald E, Hauser SL, Fauci AS, Longo DL, Kasper DL, Jameson JL, editors. Harrison's Principles of internal medicine. 15th ed. New York: McGraw Hill; 2001. p. 867-82.
  4. Evans WE, Christensen ML. Interactions with methotrexate. J Rheumatol 1985; 12(Suppl 12): 15-20.
  5. Tailer SA, Gupta AK, Walder SE, Shear NH. Peripheral edema due to itraconazole-nifedipine interaction - A case report. Arch Dermatol 1996; 132: 350-2.

Copyright 2004 - Indian Journal of Dermatology, Venereology, Leprology


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