 |
| About Bioline | All Journals | Testimonials | Membership | News |
|
||||||
|
||||||
Indian Journal of Dermatology, Venereology and Leprology, Vol. 72, No. 4, July-August, 2006, pp. 315-321 Resident's Page Scoring systems in dermatology Bhor Urmila, Pande Sushil Department of Dermatology, Seth GS Medical College and KEM Hospital, Mumbai Code Number: dv06108 Dermatologists have the privilege of examining the largest organ of the body. However, unlike other organs, there are hardly any tests of clinical significance that measure skin function. In dermatological practice, methods of evaluating the severity of skin diseases are often crude, subjective and not reproducible, which creates discrepancy in results and inter-individual variations. Hence, to maintain objectivity in observations, scores are used to evaluate the severity of skin diseases. This is particularly important for monitoring the response to therapy and for evaluating the efficacy of new drugs. Over the years scoring systems have been developed for a number of skin diseases. This has greatly helped the cause of clinical practice and clinical research. This article deals with scores that are commonly used and uniformly accepted for the ease of assessment of common skin diseases. ATOPIC DERMATITIS Scores that are commonly used for objective assessment of atopic dermatitis are
SCORAD (SCORing Atopic Dermatitis)[1] The SCORAD Index is a composite score based on 3 subscores: A = The extent score based on body surface area calculated using the 'Rule of 9'. SCORAD = A/5 + 7(B/2) + C The disadvantage of this scoring system is the significant interobserver variation which makes subsequent assessment of the patient by the same observer necessary. SASSAD[2] The Six Area, Six Sign Atopic Dermatitis severity score has proved to be a simple and effective system for recording and monitoring disease activity in atopic dermatitis. The score is obtained by grading six signs (erythema, exudation, excoriation, dryness, cracking and lichenification), each on a scale of 0 (absent), 1 (mild), 2 (moderate), or 3 (severe), at each of six sites (arms, hands, legs, feet, head and neck, trunk). The maximum score is 108. A modified version of the SASSAD known as the six-area 'total body severity assessment (TBSA)'has also been described. The TBSA, which has a maximum score of 108, differs from SASSAD in that it assesses infiltration and vesicles and/or papules, and excludes lichenification.[3] Other scores in AD that are uncommonly used are listed in [Table - 1]. PSORIASIS Psoriasis area severity index (PASI)[10] The final formula for PASI score is: PASI = 0.1 (Eh + Ih + Dh) Ah + 0.2 (Eu + Iu + Du) Au + 0.3 (Et + It+ Dt) At + 0.4 (El + Il + Dl) Al The maximum score of PASI is 72. PASI 75 is a 75% reduction of baseline PASI score. It is commonly considered as a denominator for satisfactory results of any treatment modality for psoriasis. Other scores that are used for psoriasis are stated in [Table - 2]. TOXIC EPIDERMAL NECROSIS (TEN) The score commonly used for assessing the patients of TEN is SCORTEN.[14] Scoring is based on the evaluation of seven independent risk factors within the first 24 hours of admission. One point is assigned to each variable. The value of the total number of points determines the predicted mortality: 0-1 points-3.2% mortality; 2 points-12.1%; 3-35.3%; 4-58.3%; ³5-90%. [Table - 3] VITILIGO Two scores designed for the assessment of vitiligo are vitiligo area severity index (VASI)[15] and vitiligo disease activity score (VIDA).[16]
Vitiligo area severity index The VASI for each body region is determined by the product of the area of vitiligo in hand units and the extent of depigmentation within each hand unit measured patch. Total body VASI = S All body sites [Hand Units] ´ [Residual depigmentation] Vitiligo disease activity score (VIDA) SCLERODERMA Scores used for scleroderma are summerized in [Table - 4].HIRSUTISM The Ferriman and Gallwey score[22] measures hirsutism in women by the degree of hair growth in 11 body regions, out of which the forearm and hand, lower leg and feet are not included in the "hormonal" score. This is a time consuming and apparently complex semiquantitative scoring system for hirsutism. [Table - 5] Even if hirsutism is present bilaterally on the extremities (upper arms, forearms, thighs and lower legs), only a single value is entered. Ferriman Gallwey hormonal hair score = Sum of all scores. The minimum score is zero and the maximum is 36. Obviously, the higher the score, the more hirsute is the woman. A score of less than 8 is considered as non hirsute, 8-16 as mild hirsutism, 17-25 as moderate hirsutism, and more than 25 as severe hirsutism. A score of more than 6 in Caucasian women indicates abnormal hair distribution. Each ethnic group may have a different upper limit of the normal value. PEMPHIGUS VULGARIS[23] Pemphigus area and activity score (PAAS) is a specific scoring system that has been suggested by Agarwal et al[23] for the clinical assessment of severity and progression of pemphigus vulgaris. PAAS is calculated separately for cutaneous and mucus membrane lesions [Table - 6][Table - 7]. Total score is calculated by adding up the cutaneous score and the mucous membrane score. MELASMA Melasma area severity index (MASI) is developed by Kimbrough-Green et al for the assessment of melasma.[24] The severity of the melasma in each of the four regions (forehead, right malar region, left malar region and chin) is assessed based on three variables: percentage of the total area involved (A), darkness (D), and homogeneity (H). A numerical value assigned for the corresponding percentage area involved is as follows: 0=no involvement; 1=< 10% involvement; 2=10-29% involvement; 3=30-49% involvement; 4=50-69% involvement; 5=70-89% involvement; and 6=90-100% involvement. The darkness of the melasma (D) is compared to the normal skin and graded on a scale of 0 to 4 as follows: 0=normal skin color without evidence of hyperpigmentation; 1=barely visible hyperpigmentation; 2=mild hyperpigmentation; 3=moderate hyperpigmentation; 4=severe hyperpigmentation. Homogeneity of the hyperpigmentation (H) is also graded on a scale of 0 to 4 as follows: 0=normal skin color without evidence of hyperpigmentation; 1=specks of involvement; 2=small patchy areas of involvement < 1.5 cm diameter; 3=patches of involvement> 2 cm diameter; 4=uniform skin involvement without any clear areas). To calculate the MASI score, the sum of the severity grade for darkness (D) and homogeneity (H) is multiplied by the numerical value of the areas (A) involved and by the percentages of the four facial areas (10-30%). Total MASI score: Forehead 0.3 (D+H)A + right malar 0.3 (D+H)A + left malar 0.3 (D+H)A + chin 0.1 (D+H)A ACNE VULGARIS Scoring systems for assessment of acne vulgaris are used in some clinical trials. Salient features of some of these scoring systems like Modified Cook's method,[25] Leeds technique[26] and severity index described by Michaelsson,[27] are described here [Table - 8].URTICARIA Urticaria activity score (UAS)The UAS consisted of the sum of the wheal number score and the itch severity score.[28] The wheal numbers are graded from 0 to 3 as follows: 0 - less than 10 small wheals (diameter, < 3 cm); 1- 10 to 50 small wheals or less than 10 large wheals (diameter, > 3 cm); 2 - greater than 50 small wheals or 10 to 50 large wheals; and 3 - almost the whole body is covered. The severity of the itching is graded from 0 to 3 (0, none; 1, mild; 2, moderate; and 3, severe). ALOPECIA AREATA In a study comparing efficacy of azelaic acid and anthralin for patchy alopecia areata, Sansaz et al used terminal hair regrowth score (RGS) which encompasses a scale ranging from 0 (inadequate response) to 2 (complete response).[29] National Alopecia Areata Foundation working committee has devised "Severity of Alopecia Tool score" (SALT score).[30] Scalp is divided into 4 areas namely, Vertex - 40% (0.4) of scalp surface area; right profile of scalp - 18% (0.18) of scalp surface area; left profile of scalp - 18% (0.18) of scalp surface area; Posterior aspect of scalp - 24% (0.24) of scalp surface area. Percentage of hair loss in any of these areas is percentage hair loss multiplied by percent surface area of the scalp in that area. SALT score is the sum of percentage of hair loss in all above mentioned areas. For e.g., if the percentage hair loss in vertex, right profile, left profile and posterior aspect is 20, 30, 40 and 50% respecively; then, SALT score = (20 ´ 0.4) = (30 ´ 0.18) + (40 ´ 0.18) + (50 ´ 0.24) = 8+5.4+7.2+12 = 32.6 DYSHIDROTIC ECZEMA Dyshidrotic eczema area and severity index (DASI) is proposed for dyshidrotic eczema.[31]
Dyshidrotic eczema area and severity index (DASI) DASI was found to be a simple and useful tool to assess the severity of dyshidrotic eczema and the effect of therapy. Thus application of mind helps to design scores for semi-objective assessment of skin diseases. Till better objective parameters are developed, scores will continue to remain the gold standard for assessing the severity of dermatological diseases in clinical research. References
Copyright 2006 - Indian Journal of Dermatology, Venereology and Leprology The following images related to this document are available:Photo images[dv06108t5.jpg] [dv06108t4.jpg] [dv06108t1.jpg] [dv06108t6.jpg] [dv06108t2.jpg] [dv06108t8.jpg] [dv06108t7.jpg] [dv06108t3.jpg] |
| |||||||||
