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Indian Journal of Human Genetics
Medknow Publications on behalf of Indian Society of Human Genetics
ISSN: 0971-6866 EISSN: 1998-362x
Vol. 15, Num. 3, 2009, pp. 143-144

Indian Journal of Human Genetics, Vol. 15, No. 3, September-December, 2009, pp. 143-144

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Adenocarcinoma of the colon and rectum in the Kashmiri population

Department of Immunology and Molecular Medicine, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir - 190 011Correspondence Address:Department of Immunology and Molecular Medicine, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir - 190 011 vc.tmuk@gmail.com

Code Number: hg09031

DOI: 10.4103/0971-6866.60192

Kashmir valley located in the northern division of India, surrounded by Himalayas has an unique ethnic population living in a temperate environmental conditions having distinctive food habits which play an overwhelming role in the development of GIT cancers over the genetic factors. [1],[2],[3] The food habits include consumption of sun-dried and smoked fish and meat, dried and pickled vegetables, red chilly, Hakh (a leafy vegetable of Brassica family), hot noon chai (salted tea) and Hukka (water pipe) smoke. [4] As previously reported, [5] the etiology and incidence of various GIT cancers in this population has been attributed to a probable exposure to nitroso compounds, amines and nitrates reported to be present in these local food stuffs.

Colorectal cancer being the commonest cancer, is the major cause of mortality and morbidity worldwide, there are nearly one million new cases of colorectal cancer diagnosed world-wide each year and half a million deaths. [6] The incidence of this malignancy shows considerable variation among racially or ethnically defined populations in multiracial/ethnic countries. Kashmir has been reported by now as a high-incidence area of GIT cancers. [1],[3],[4] Colorectal Cancer in Kashmir valley is the third most common GIT cancer after esophageal and gastric as per SKIMS Medical record registry, with almost 124 cases reported in 2009.

Here we have presented three cases of colorectal cancer in form of images, obtained from the patients who visited Department of General Surgery of SKIMS, for the resective surgery for the immediate treatment of the cancer.[Figure - 1],[Figure - 2],[Figure - 3]

References

1.Shah A, Jan GM. Pattern of cancer at Srinagar (Kashmir). Indian J Pathol Microbiol 1990;33:118-23.  Back to cited text no. 1    
2.Murtaza I, Mushtaq D, Margoob MA, Dutt A, Wani NA, Ahmad I, et al. A study on p53 gene alterations in esophageal squamous cell carcinoma and their correlation to common dietary risk factors among population of the Kashmir valley. World J Gastroenterol 2006;12:4033-7.  Back to cited text no. 2  [PUBMED]  [FULLTEXT]
3.Salam I, Hussain S, Mir MM, Dar NA, Abdullah S, Siddiqi MA, et al. Aberrant promoter methylation and reduced expression of p16 gene in esophageal squamous cell carcinoma from Kashmir valley: A high-risk area. Mol Cell Biochem 2009;332:51-8.  Back to cited text no. 3  [PUBMED]  [FULLTEXT]
4.Mir MM, Dar NA, Gochhait S, Zargar SA, Ahangar AG, Bamezai RN. p53 Mutation profile of squamous cell carcinomas of the esophagus in Kashmir (India): A high-incidence area. Int J Cancer 2005;116:62-8.  Back to cited text no. 4  [PUBMED]  [FULLTEXT]
5.Siddiqi M, Kumar R, Fazili Z, Spiegelhalder B, Preussmann R. Increased exposure to dietary amines and nitrate in a population at high risk of esophageal and gastric cancer in Kashmir (India). Carcinogenesis 1992;13:1331-5.  Back to cited text no. 5  [PUBMED]  [FULLTEXT]
6.Boyle P, Elena M. Epidemiology of colorectal cancer. Br Med Bull 2002;64:1-25.  Back to cited text no. 6    

Copyright 2009 - Indian Journal of Human Genetics


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