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Indian Journal of Human Genetics
Medknow Publications on behalf of Indian Society of Human Genetics
ISSN: 0971-6866 EISSN: 1998-362x
Vol. 16, Num. 1, 2010, pp. 43-43

Indian Journal of Human Genetics, Vol. 16, No. 1, January-April, 2010, pp. 43

Letter To Editor

Glanzmann's thrombasthenia and molecular mimicry

Viroj Wiwanitkit

Wiwanitkit House, Bangkhae, Bangkok Thailand 10160.

Correspondence Address: Viroj Wiwanitkit, Wiwanitkit House, Bangkhae, Bangkok Thailand 10160. wviroj@yahoo.com

Code Number: hg10010

DOI: 10.4103/0971-6866.64942

Sir,

I recently read with great interest the current publication of Ghosh et al.[1] It is interesting that the antiplatelet antibodies can also be present in patients who had not received any platelet transfusion. In this regard, the molecular mimicry might be the responsible mechanism as the author′s proposal. Definitely, there must be a previous stimutation, which is assumed to be an autoantigen that can lead to the generation of antiplatelet antibodies. [2] The other proposal regarding the possibility of another mechanism seems to be a weaker hypothesis. Considering that the author had performed well control on the laboratory analysis system, there should not be other interference on the analysis.

References

1.Ghosh K, Kulkarni B, Shetty S, Nair S. Antiplatelet antibodies in cases of Glanzmann's thrombasthenia with and without a history of multiple platelet transfusion. Indian J Hum Genet 2009;15:23-7.2.   Back to cited text no. 1    
2.Gruel Y, Brojer E, Nugent DJ, Kunicki TJ. Further characterization of the thrombasthenia-related idiotype OG: Antiidiotype defines a novel epitope(s) shared by fibrinogen B beta chain, vitronectin, and von Willebrand factor and required for binding to beta 3. J Exp Med 1994;180:2259-67.  Back to cited text no. 2  [PUBMED]  [FULLTEXT]

Copyright 2010 - Indian Journal of Human Genetics

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