Journal of Health Population and Nutrition, Vol. 28, No. 2, March-April, 2010, pp. 143-148
Coverage of vitamin A capsule programme in Bangladesh and risk factors associated with non-receipt of vitamin A
Richard D Semba1, Saskia de Pee2, Kai Sun1, Nasima Akhter3, Martin W Bloem2, VK Raju4
1 Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Correspondence Address:Richard D Semba, Wilmer Eye Institute, Johns Hopkins School of Medicine 550 N. Broadway, Suite 700 Baltimore, MD 21205, USA firstname.lastname@example.org
Code Number: hn10019
Vitamin A supplementation reduces child morbidity, mortality, and blindness. The coverage of the national vitamin A programme and risk factors for not receiving vitamin A were characterized using data from the Bangladesh Demographic and Health Survey 2004. Of 3,745 children aged 18-59 months, 3,237 (86.4%) received a vitamin A capsule each within the last six months. Children who missed vitamin A were more likely to be stunted (prevalence ratio [PR] 0.97, 95% confidence interval [CI] 0.95-1.00) and come from a family with a previous history of mortality of children aged less than five years (PR 0.95, 95% CI 0.91-0.99). Maternal education of ≥10 years (PR 1.09, 95% CI 1.04-1.13), 7-9 years (PR 1.08, 95% CI 1.04-1.12), and 1-6 years (PR 1.05, 95% CI 1.02-1.08) compared to no formal education was associated with the child not receiving vitamin A in a multivariate model, adjusting for potential confounders. Children missed by the vitamin A programme were more likely to come from families with lower maternal education. Special efforts are required to ensure that the coverage of the national vitamin A programme is increased further so that the most vulnerable children are also better protected against morbidity, mortality, and blindness.
Keywords: Blindness; Child; Morbidity; Mortality; Risk factors; Vitamin A; Vitamin A deficiency; Bangladesh
Vitamin A deficiency is a major public-health prob-lem in Bangladesh, where it is a leading cause of morbidity, mortality, and blindness among pre-school children ,, . Vitamin A is found as retinyl esters as in egg-yolk, whole milk, butter, and liver, or as provitamin A carotenoids, as in dark green-leafy vegetables, carrots, and red/orange/yellow-coloured fruits. Vitamin A deficiency can result in more severe infections and greater mortality due to diarrhoea and measles, especially in preschool children because vitamin A is essential for normal immune function. It is also essential for growth, reproduction, and vision  .
Many developing countries worldwide have es-tablished programmes to provide periodic supple-mentation of high-dose vitamin A to increase child survival and reduce the incidence of nutritional blindness. Vitamin A supplementation is one of the most cost-effective interventions for child health  and is known to reduce mortality of preschool children by nearly one-quarter  . The Millenni-um Development Goals (MDGs) include reducing child mortality by two-thirds between 1990 and 2015 ,, , and the effective coverage of periodic supplementation programmes of high-dose vita-min A is considered one of the most cost-effective strategies in reaching this goal. The specific aims of this study were to characterize the coverage of the national vitamin A capsule programme in Bangla-desh and to identify the factors associated with re-ceipt or non-receipt of a vitamin A capsule within the last six months. For these, we examined popu-lation-based, demographic and health survey data from Bangladesh.
Materials and Methods
The study subjects included preschool children and their families who participated in the Bangladesh Demographic and Health Survey (BDHS) 2004, a nationally representative survey of 10,500 households selected from 361 clusters throughout Bangladesh  . The primary objective of the survey was to provide data to monitor the population and health situation in Bangladesh. The survey used a multistage cluster sample that was based upon the 2001 Bangladesh Census, and it produced esti-mates for six divisions of the country: Barisal, Chit-tagong, Dhaka, Khulna, Rajshahi, and Sylhet. Data were collected during 1 January-24 May 2004, and the study was conducted under the authority of the National Institute for Population Research and Training of the Ministry of Health and Family Wel-fare, Government of Bangladesh.
Households were selected by multistage sampling. The primary sampling units for the BDHS 2004 were subdivisions, known as enumeration areas, and the BDHS 2004 sample was a stratified multi-stage cluster sample consisting of 361 primary sampling units-122 in the urban area and 239 in the rural area  . The BDHS 2004 used four sets of questionnaire that collected household and demo-graphic information, including whether children aged less than five years (under-five children) in the household had received a vitamin A capsule within the last six months, receipt of tetanus-diphtheria-pertussis (DPT), oral poliovirus (OPV), and measles vaccines, and any history of neonatal, infant, or under-five child mortality in the family. For each child, mothers were asked if they had vaccination card for the child, and if so, to show the card to the interviewer. When the card was available, the interviewer entered the dates of immunization into the form in the questionnaire. If the card was not available or vaccinations were not recorded, moth-ers were asked questions to recall whether the child had received each vaccine. Twelve interviewing teams conducted fieldwork-each team consisting of one male supervisor, one female field editor, five female interviewers, two male interviewers, and one member of the logistics staff. Four quality-con-trol teams of two persons each were used for moni-toring the field teams  .
The study protocol complied with the principles enunciated in the Helsinki Declaration  . The field teams were instructed to explain the purpose of the survey to the mother or father, and data col-lection proceeded only after obtaining informed consent. Participation was voluntary, no remunera-tion was provided to subjects, and all subjects were free to withdraw at any stage of the interview. Data from the BDHS 2004 is in the public domain and was obtained through Measure DHS  . The Insti-tutional Review Board of the Johns Hopkins Uni-versity School of Medicine approved the plan for secondary analysis of data.
In Bangladesh, all children aged 12 months and older (i.e. 12-59 months) are eligible to receive vitamin A supplementation every six months. Children of this age can receive vitamin A sup-plementation either through national immuniza-tion days or through the National Vitamin A Plus Campaign. Distribution of vitamin A capsules takes place twice a year through the national immuniza-tion days or National Vitamin A Plus Campaign, with specific dates announced in advance for fixed-site distribution. National vitamin A supplemen-tation took place in October 2003 and February 2004.
The sample for analysis was restricted to households that had at least one child aged 18-59 months. The national vitamin A programme distributes capsules to children who are aged 12 months and older, and the question in the survey asked whether the child had received a capsule within the last six months. The youngest child, aged 18-59 months, in the household was used as the index of a child receiving a vitamin A capsule (i.e. households were not counted more than once because of clustering within households and children aged 18 months and older had all been eligible to receive a vitamin A capsule in the previous 6 months). The child growth standards of the World Health Organiza-tion were used as the reference growth curves  . Stunting, underweight, and wasting were defined as height-for-age, weight-for-age, and weight-for-height z-scores <-2 respectively. Severe stunting, severe underweight, and severe wasting were de-fined as height-for-age, weight-for-age, and weight-for-height z-scores <-3 respectively. Maternal age was divided into quartiles. Maternal and paternal education was categorized as 0, 1-6, 7-9, and >10 years. The number of children in the family was used as an indicator of crowding. Multivariate lo-gistic regression models were used for examining the relationship between maternal education and other variables and receipt of a vitamin A capsule in the last six months. Variables were included in the multivariate models if significant in univariate analyses. The p value of 0.05 was considered sig-nificant. Analyses of data were conducted using the SAS survey software (version 9.11) (SAS Institute, Cary, NC, USA).
Of 3,745 children aged 18-59 months, 3,237 (86.4%) received a vitamin A capsule each within the last six months. The number and percentage of children who did not receive a vitamin A capsule in the last six months by demographic and other characteristics and the corresponding prevalence ratios (PRs) are shown in [Table - 1]. The PR for receipt of a vitamin A capsule in the last six months was not signifi-cantly different from 1.00 for age and of the child′s sex, or for underweight, severely-underweight, wasted, or severely-wasted children. The preva-lence ratio for receipt of vitamin A in the last six months was significantly <1.00 for stunting, se-vere stunting, history of diarrhoea in the last two weeks in the children, and a history of infant mor-tality or under-five mortality in the child′s fami-ly. The PR for receipt of vitamin A in the last six months was significantly >1.00 among chil-dren with older mothers, mothers or fathers with greater levels of education, and for those who re-ceived two or more doses of DPT, two or more doses of OPV, or measles immunization, and for children who came from families which owned a radio or a television.
Higher level of maternal education, greater mater-nal age, and ownership of a radio or a television were significantly associated with the child receiv-ing a vitamin A capsule in the last six months in a multivariate model, adjusting for location [Table - 2]. When under-five child mortality was added to the previous multivariate model, the relationship between non-receipt of a vitamin A capsule and previous under-five child mortality in the family was of borderline significance (PR 1.03, 95% CI 0.99-1.08).
Data from the BDHS 2004 showed that the coverage of the vitamin A supplementation programme to prevent morbidity, mortality, and blindness in pre-school children was relatively high in Bangladesh, exceeding the 85% coverage rate recommended by the World Bank  . The findings of the present study showed that the remaining 14% of preschool children who missed a vitamin A capsule in the last six months were more likely to come from families that had higher under-five child mortality. When under-five child mortality was included in a mul-tivariate model adjusting for other covariates, the relationship between non-receipt of a capsule and previous under-five child mortality in the family was of borderline significance. Children missed by the programme may be those who could probably benefit the most, given the higher history of under- five child mortality in their families.
In the present study, children who were missed by the vitamin A capsule-distribution programme were less likely to have received DPT, OPV, and measles immunization. In the national vitamin A programme in Indonesia, there was also a similar, lower coverage among children who missed child-hood immunizations  . The lack of immuniza-tion places children who missed vitamin A at an even higher risk of morbidity and mortality from vaccine-preventable infectious diseases. Vitamin A deficiency increases the risk of morbidity due to measles, including the severity of diarrhoeal dis-ease, measles-related pneumonia, blindness, and mortality  . These findings suggest that the de-mographic factors that impact a child′s participa-tion in vitamin A supplementation programmes may also impact participation in other public-health interventions.
A previous report from Helen-Keller International showed that the coverage of the vitamin A supple-mentation programme was below 70% in the Chit-tagong Hill Tracts, a district within Chittagong divi-sion  . In the present study, the overall coverage in Chittagong division was 89.1%, and separate figures were not available for the Chittagong Hill Tracts alone.
Results of a previous study in Indonesia showed that children who were missed by the vitamin A programme were more likely to be stunted, un-derweight, or wasted  . In the present study in Bangladesh, there were significant differences in the prevalence of stunting and severe stunting between children who did and did not receive a vitamin A capsule in the last six months. Stunted children are more likely to suffer from vitamin A deficiency dis-orders and have higher morbidity due to infectious diseases  , and they represent a vulnerable group which could benefit if the coverage of the vitamin A programme could be expanded.
The national vitamin A programme was initially established by the Bangladesh Programme for the Prevention of Blindness with support from the United Nations Children′s Fund in 1973  . Sup-plementation of vitamin A has been shown to pro-tect against clinical vitamin A deficiency, as indicat-ed by nightblindness, among preschool children in Bangladesh  . In Indonesia and Viet Nam, the ex-panded coverage of the national vitamin A supple-mentation programme was also accompanied with large reductions in hospital admissions for xeroph-thalmia , . The national vitamin A supplemen-tation programme in Ethiopia achieved a coverage of less than 50% in 2005, and children who did not receive vitamin A in the last six months were more likely to come from families with lower maternal and paternal education  .
The findings of the present study suggest that ma-ternal education is an important factor relating to receipt of a vitamin A capsule. A higher level of for-mal education achieved by girls may be a key factor in breaking the intergenerational cycle of malnu-trition and poverty  . Since younger maternal age was also associated with the lower coverage, further efforts are, thus, required by the vitamin A supplementation programmes to reach young, uneducated primigravida mothers. Also, children of households of higher socioeconomic status were more likely to have received a vitamin A capsule. The coverage ranged from 77.2% in Barisal and 78.8% in Sylhet to 89.1% in Dhaka and Chittagong divisions, and there were variations between areas within each division. Thus, it is also important for programmes to identify areas with a lower cover-age and implement measures to increase the cover-age and, in particular, ensure the coverage of the most vulnerable children (stunted, of lower socio-economic background, and with uneducated and younger mothers).
Worldwide, 9.7 million children die each year; most deaths occur from preventable causes, and nearly all deaths occur in poor countries  . About 63% of deaths of children could be prevented with full implementation of the few known and effective interventions to reduce child mortality, such as vitamin A supplementation  . The reduction of under-five child mortality by two-thirds between 1990 and 2015 is one of the MDGs that was en-dorsed by 189 countries in September 2000  . Although the coverage of the vitamin A capsule programme in Bangladesh is relatively high, ef-forts to reach 14% of the children missed by the programme may yield substantial benefit in re-ducing child deaths and nutritional blindness.
The study was supported by the Eye Foundation of America and a Lew R. Wasserman Merit Award from Research to Prevent Blindness to Dr. Semba.
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