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Journal of Indian Association of Pediatric Surgeons, Vol. 10, No. 1, January-March, 2005, pp. 44-47 Original Article Urogenital anomalies associated with anorectal malformation Srivastava Vaishali, Ray A.K., Patra R., Saha Basu K., Samanta N., Saha K. Department of Pediatric Surgery, N.R.S. Medical College and Hospital, Kolkata Code Number: ip05011 Abstract Background: The objective of the paper is to review the incidence
and types of associated urogenital anomalies (U.G.A.) we encountered
in patients with anorectal malformations (A.R.M.) and compare the results
with previously published world literature.
Key words: Urogenital anomalies, anorectal malformations, congenital INTRODUCTION Congenital anomalies of the urogenital tract are the leading associated anomalies in patients with ARM.[1] Previous studies show the incidence of UGA associated with high or intermediate forms of ARM to be approximately 50-60%[2] and with low anomalies to be 15-20%. Urologic abnormalities have been found to predominate in this group of anomalies.[3] Materials and Methods The records of 220 patients with congenital anorectal malformations (ARM) who were admitted from May 2002 to April 2003 were reviewed retrospectively. Of these, 65 (29.65%) were follow-up patients who had already undergone a primary colostomy and were admitted for a revision of the colostomy, for definitive operation or for a colostomy closure following definitive operation. [Table - 1].The rest 70.45% (155 patients) were newly diagnosed cases of ARM [Table - 2]. All patients underwent ultrasound (US) studies of the KUB region and pelvis for detection of urogenital abnormalities and lumbosacral radiography. Voiding cystourethrography (VCUG) was done in patients diagnosed with an abnormality in USG and other investigations like nuclear renography, IVU, urodynamic studies, fistulography, buccal smear and karyotyping were done in appropriate cases. All follow-up patients had their serum urea and creatinine levels evaluated. The patients were grouped into two categories. The patients with genital
abnormalities were clinically diagnosed with external examinations followed
by laboratory investigations. The urological anomalies were mainly detected
by imaging studies (23 out of 25). Results In this study a total of 55 patients (24.54%), [10 (18%) females and 45 (81.82%) males], had an abnormality of the urogenital tract. There were 25 (45.45%) urinary and 30 (54.55%) genital abnormalities. [Table - 3] and [Table - 4]. The most common abnormalities were hypospadias (9 patients -16.36%) and penoscrotal transposition (7 patients -12.72%). Undescended testes were seen in 4 patients (7.27%), unilateral in 3 and bilateral in 1. Two patients (3.63%) had ambiguous genitalia. 1 patient had normally descended testes in the scrotal sac but no penis (urethral opening was seen in the anterior wall of rectum) while another had a pseudoduplication of the external genitalia with an accessory phallus and scrotal sac.1 patient had a complete duplication of external genitalia. Two patients had ovarian cysts (3.63%), 1 antenatally diagnosed had bilateral ovarian cysts while the other had a unilateral ovarian cyst. 1 patient had vaginal atresia. The most common renal abnormality viz. renal ectopia, was diagnosed
in 5 patients (9.09%). Of these 2 cases were of crossed renal ectopia and the rest were pelvic kidneys. Unilateral moderate to severe hydronephrosis, due to PUJ obstruction, was present in 4 patients (7.27%). Unilateral renal agenesis was detected in 3 patients (5.45%). Urethral stricture was also present in 3 patients (5.45%);
of these, 1 had multiple urethral strictures [Figure - 1].
3 patients (5.45%) were demonstrated to have VUR [Figure - 2] in
VCUG which was performed in in 55 cases. Unilateral renal dysplasia was
detected in 2 patients (2.63%). One female with bladder exstrophy
presented at the age of 9 years with severe constipation due to a stenotic
anterior ectopic anus, having had no past surgical treatment. 1 patient
had a patent urachus and 1 had an ectopic urethra. Discussion Of all anomalies associated with ARM, urogenital anomalies are the most frequent.[1] The incidence of associated UGA. from different series varies widely from 25% to 60%[1],[4]-[13] reflecting the number of patients with higher versus lower malformations.Partridge and Gough, in 1961, reported 9% incidence of urologic anomalies in low ARM and 30% in high ARM.[5] McLorie et al noted incidence of 20% and 60% respectively.[11] Parrot reported figures of 14% with low, 21% with intermediate and 40% with high anomalies.[12] Rich et al showed 25%, 42% and 71% associations.[6] Tohda et al found UGA in 38.1% of low, 65.5% of intermediate and 85.7% of high ARM.[13] Our study shows figures of 16.12%, 22.54% and 68.75% respectively in low, intermediate and high ARM cases. Genital anomalies were found in 14% and urologic anomalies in 25.6% by Sangkhathat et al .[14] The most common abnormality in our study was hypospadias, seen in 9 cases (4.09% overall). Hoekstra et al reported a 6% incidence of hypospadias.[7] Renal agenesis, reported to be the most common UGA in literature[4],[6] was encountered in only 3 patients in our study. Instead the most common renal anomaly seen was renal ectopia, present in 5 patients (2.27%). VUR was seen only in 3 patients of the 55 who underwent VCUG (5.45% of patients investigated and 1.36% overall) as against 47% by Narasimha Rao et al[16], 14% by Rich et al[6] and 8.6% by Sangkhathat et al .[14] Ideally, the ARGUS protocol devised by Boemer et al[15] should be used for evaluating newborns with ARM. However, the overwhelming number of patients we deal with(as shown in this study) and the poor socioeconomic condition of most of these patients, precludes the use of all investigations suggested by Boemer et al to be mandatory in all patients with ARM. We routinely performed USG and X-ray spine (to detect vertebral anomalies) in all cases, and VCUG was done only in patients detected with an UGA. Thus, the actual incidence of reflux is probably higher than diagnosed. Conclusion ARM is associated in a large number of cases with urogenital anomalies (UGA) of a wide diversity ranging from an undescended testis to duplication of the external genitalia and from renal agenesis to multiple urethral strictures.
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