Journal of Postgraduate Medicine Medknow Publications and Staff Society of Seth GS Medical College and KEM Hospital, Mumbai, India ISSN: 0022-3859 EISSN: 0972-2823 Vol. 49, Num. 2, 2003, pp. 148-150

Journal of Postgraduate Medicine, Vol. 49, No. 2, April-June, 2003, pp. 148-150

Case Report

Laparoscopic Bilateral Nephroureterectomy and Bladder Cuff Excision for Native Renal Pelvic and Ureteral Transitional Cell Carcinoma after Renal Transplantation

Chen CH, Huan SK, Lin JT,* Chiu AW

Division of Urology, Department of Surgery, Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan; Taipei Medical University, School of Medicine, Taipei, Taiwan; National Yang-Ming University, Taipei, Taiwan and *Chang Gung Memorial Hospital, Chyayi, Taiwan.
Address for Correspondence: Allen W. Chiu, MD, No. 901, Chung-Hwa Road, Yung-Kang City, Tainan, Taiwan. E-mail: chimeigu@venus.seed.net.tw

Code Number: jp03038

Abstract:

A 37-years-old female who was suffering from end-stage renal disease for about 6 years received allograft renal transplantation 4 years ago. She has been receiving 50mgof Cyclosporin A orally daily for immuno-suppression since then. Gross haematuria was noted and computerised tomography showed native left renal pelvic and ureteral multi-focal transitional cell carcinoma with severe hydronephrosis. Laparoscopic bilateral nephroureterectomy and bladder cuff excision were performed. In the past, history of previous operation was considered a relative contraindication for laparoscopic surgery. To our knowledge, we present the first case of laparoscopic treatment for native renal pelvic and ureteral transitional cell carcinoma after renal allograft transplantation without a hand-assisted device. This case shows the feasibility of laparoscopic bilateral nephroureterectomy in patients with transplanted kidneys. (J Postgrad Med 2003;49:148-150)

Key Words: Carcinoma, transitional cell, kidney transplantation, laparoscopy

Renal transplant recipients need long-term immunosuppressive therapy and it is, thus theorised that they are prone to develop malignant diseases. As much as 10% of allograft recipients are estimated to develop malignant tumours.¹ However, transitional cell carcinoma arising from the native renal pelvis after a renal transplantation is still very rare. To our knowledge, we present the first case of laparoscopic treatment for native renal pelvic and ureteral transitional cell carcinoma after renal allograft transplantation without a hand-assisted device.

Case History

A 37-years-old female suffering from end-stage renal disease the past 6 years had received allograft renal transplantation 4 years ago. She was on 50mg Cyclosporin A orally daily for immuno-suppression since then. Gross haematuria was noted since 2 months. Cystoscopy revealed left ureteral transitional cell carcinoma protruding into the urinary bladder through the left ureteral orifice. Computerised tomography showed native left renal pelvic and ureteral multi-focal transitional cell carcinoma with hydronephrosis. Open nephroureterectomy and bladder cuff excision was suggested. Due to her strong desire to minimize the second operative scar, she was referred to our hospital for laparoscopic surgery.

Magnetic resonance imaging (Figure 1) was performed to delineate the tumour progression. Atrophy of right kidney was noted. Bilateral laparoscopic nephroureterectomy was successfully performed through transperitoneal approach by a 4-trocar technique. The left kidney and ureter were pulled out through a 6 cm. incision over her previous left lower abdominal scar for renal transplantation and left bladder cuff excision was done through this wound by open method. Right kidney and ureter were removed from the same wound after laparoscopic excision of right bladder cuff.

The pathologic examination revealed multiple transitional cell carcinoma extending from left side renal pelvis to the whole ureter with grade III/IV (stage T2N0M0). Atrophy of right kidney with in-situ transitional cell carcinoma extending from right renal pelvis to the upper part of ureter was also noted (Figures 2 & 3). Surgical margins of the specimen were free of tumour. The total operation time was 5 hours and 15 minutes. The intraoperative bleeding was about 500 ml. Patient was discharged 6 days after operation. However, a small recurrent bladder tumour was noted 6 weeks later by cystoscopy. Transurethral resection of the recurrent tumour in the bladder was done and it was found to be transitional cell carcinoma (grade II/IV, stage T1). After 6 months of followup with cystoscopy and computerised tomography, there was no evidence of tumour recurrence. Her creatinine was 1.1 mg./dl. Chemotherapy was suggested but the patient refused.

Discussion

The incidence of malignancy following organ transplantation has been reported to be three times the excepted incidence for the general population.² It was reported that the incidence of transitional cell carcinoma in a renal transplant population is about 0.8%.³ However, in our case, it is difficult to determine whether the tumour occurred before or after the renal transplantation.

In the past, history of a previous operation was considered a relative contraindication for laparoscopic surgery because of the possibility of tissue adhesions that would obscure surgical landmarks. In our case, there were severe adhesions in the retroperitoneal space near the middle third and lower third of left ureter due to previous renal transplantation. Chueh et al. reported their experience of hand-assisted laparoscopic bilateral nephroureterectomy on four patients with normal graft function after renal transplantation.⁴ They made a 7.5 cm long infraumbilical midline incision for a hand-assisted device instead of using the previous incision for renal transplantation. Our case proves that laparoscopic bilateral nephroureterectomy in patients with transplanted kidneys is possible without a hand-assisted device. Actually, the magnification of laparoscopy makes dissection between adhesive tissues easier and it is possible to safely dissect out the native ureter without damaging the transplanted kidney.

Complete native genitourinary exenteration with ileal conduit has been reported for synchronous multi-focal transitional cell carcinoma after renal transplantation.⁵ However, this technique reduced the quality of life and patient's intention to undergo surgery. In this case, we decided to preserve her urinary bladder. The best therapy for transitional cell carcinoma after renal transplantation still remains controversial.

References

1. Colombo T, Zigeuner R, Zitta S, Petritsch PH, Hubmer G. Orthotopic neobladder in a woman after kidney transplantation. J Urol 1997;158:2236-7.
2. Thomalla JV, Leapman SB, Filo RS. Fatal transitional cell carcinoma of bladder in renal transplant recipient. Urology 1991;38:567-70.
3. Swindle P, Falk M, Rigby R, Petrie J, Hawley C, Nicol D. Transitional cell carcinoma in renal transplant recipients: the influence of compound analgesics. Br J Urol 1998;81:229-33.
4. Chueh SC, Chen J, Hsu WT, Hsieh MH, Lai MK. Hand-assisted laparoscopic bilateral nephroureterectomy in 1 session without repositioning patients is facilitated by alternating inflation cuffs. J Urol 2002;167:44-7.
5. Glassman DT, Sklar GN. Complete genitourinary exenteration for multifocal transitional cell carcinoma in renal transplant recipient. J Urol 2001;166:986-7.

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