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Journal of Postgraduate Medicine, Vol. 51, No. 1, January-March, 2005, pp. 30-35 Original Article Sino-nasal epithelial tumours: A pathological study of 69 cases Panchal L., Vaideeswar Pradeep, Kathpal D., Madiwale C.V., Prabhat D.P. Department of Pathology, Seth G. S. Medical College, Parel, Mumbai - 400 012 Code Number: jp05010 ABSTRACT BACKGROUND: Epithelial neoplasms are uncommon lesions affecting the sino-nasal tract. There are hardly any reports in the Indian literature.
AIM: To study the incidence, mode of presentation and histological types of sino-nasal epithelial tumours in the surgical pathology material.
Key Words: Nasal cavity, Para-nasal sinuses, Tumours, Papillomas, Carcinomas The nasal cavity and the para-nasal sinuses form a single functional unit with common pathological processes affecting both of them, most of which are largely inflammatory. The sino-nasal epithelium is an uncommon site for neoplastic processes, and can present an entire range of both epithelial and non-epithelial tumours.[1] The epithelial tumours are three times more frequent than the non-epithelial tumours.[1] There are hardly any reports in Indian literature on these tumours. This is a report of 69 sino-nasal epithelial tumours that were studied with respect to the incidence, mode of presentation and histological types. MATERIALS AND METHODS RESULTS In ten years, among 87,878 specimens received at the general surgical pathology laboratory, 120 were sino-nasal tumours. Sixty-nine were epithelial in nature, 20 benign and 49 malignant. It was noted that most patients with benign tumours (median age 40.5 years), were in the fourth and fifth decades while malignant lesions occurred in patients over the fifth decade (median age 55 years). In general, nasal obstruction, epistaxis and headache were symptoms common to both groups, but facial swelling, features of orbital and/or intracranial extension and lymphadenopathy were seen exclusively in the malignant variety, especially as evidenced by radiography or CT scans [Table - 1].The benign tumours, the papillomas, were received in the form of multiple polypoidal, firm and white bits with undulant or papillary surfaces [Figure - 1]. Of the 20 cases, 19 involved the nasal cavity while one was seen to affect solely the sphenoidal sinus. Seven nasal masses were also seen extending into the ipsilateral antral (4) and ethmoidal (3) sinuses. Two cases were bilateral. Sixteen papillomas were of the inverted type, characterized by infolding of the metaplastic stratified squamous epithelium with focal areas of ciliated columnar cells. Numerous micro-cysts containing nuclear debris and mucin were present, giving the epithelium a ′moth-eaten′ appearance [Figure - 1]. Stroma was either oedematous or fibro-collagenous, with chronic inflammatory cells in some. Three inverted papillomas recurred four to eight months after the initial surgery. There was no histological alteration. Four were fungiform or squamous papillomas. They were exophytic with proliferating squamous epithelium growing outwards [Figure - 2]. There were four papillomas associated with squamous cell carcinoma [Table - 2]. The first case was a 21-year-old male with multiple excisions for inverted papillomas in the past. The present admission revealed a left nasal mass, extending into the ipsilateral maxillary and sphenoidal sinuses. Microscopically, the tumour showed a spectrum of changes in the lining with usual squamous epithelium, dysplasia and invasive carcinoma [Figure - 3]. The remaining three cases showed a synchronous papilloma and carcinoma. Two were again inverted papillomas while the third was a cylindrical cell papilloma or oncocytic scheinderian papilloma. The latter revealed stratified ciliated columnar epithelial cells with eosinophilic, granular cytoplasm and round vesicular nuclei [Figure - 2]. There were foci of squamous metaplasia, dysplasia and invasive carcinoma. There were 45 sino-nasal carcinomas [Table - 2]. Specimens were received in the form of biopsies (26), partial maxillectomy (1) and total maxillectomies (14) and total maxillectomies with orbital exteneration (4) ( [Figure - 4]. The tumours were on the left side in 24 patients, on the right side in 18 and bilateral in three. They were also multi-centric, with involvement of more than one site at initial presentation. Well or moderately differentiated squamous cell carcinoma [Figure - 4] was diagnosed in 19 while five lesions showed a poorly differentiated sub-type. Sarcomatoid squamous carcinoma was seen in a 50-year-old male. The tumour was reported as a squamous cell carcinoma on biopsy. Subsequent maxillectomy revealed additional fascicular spindle cell component with pleomorphism and mitoses [Figure - 5]. There were three transitional cell carcinomas seen bilaterally in three elderly females. Ribbons of malignant cells resting on the intact basement membrane were seen [Figure - 5]. Among the 12 adenocarcinomas, the salivary gland types were the commonest; adenoid cystic in eight and muco-epidermoid in one [Figure - 6]. All the adenoid cystic carcinomas showed a characteristic cribriform pattern. Peri-neural invasion were seen in four. The patient with muco-epidermoid carcinoma presented with nasal obstruction and facial swelling. The tumour was seen to arise from the surface epithelium and was composed of islands with squamous and mucin-secreting cells. The usual non-enteric type was seen in only three [Figure - 7]. Sino-nasal undifferentiated carcinoma was seen in five. In addition to the usual symptoms of malignancy, one of the patients with a sphenoidal tumour presented with unilateral palsies of cranial nerves VII, X, XI and XII, and cervical lymphadenopathy. These tumours were composed of pleomorphic cells in sheets and lobules with focal necroses [Figure - 7]. The cells possessed scanty cytoplasm, bizarre hyperchromatic or vesicular nuclei and prominent nucleoli. DISCUSSION Sino-nasal tumours represented only 0.14% of the surgical pathology material received by our laboratory. As noted previously,[1] the epithelial tumours outnumbered non-epithelial tumours (ratio 1.44:1). There were 24 papillomas (34.8%). Though the ages ranged from 25 to 60 years, 60% occurred in the fourth and fifth decades of life and predominantly in males, as has been previously observed.[2] Among the three types i.e. fungiform or exophytic, inverted or endophytic and cylindrical or oncocytic schneiderian, the commonest variant was the inverted sub-type (an incidence of 70.76%) while the cylindrical was the rarest.[2] Inverted papillomas also formed a common sub-group in our study with an incidence of 80%.Many studies have been devoted to inverted papillomas.[3],[4],[5] This is because these tumours are often multi-centric, with a marked tendency for aggressive behaviour, recurrence after surgical excision (5-20%), and transformation to an epithelial malignancy (5-9%), most commonly squamous cell carcinoma.[3],[4] Therefore, it would be of utmost importance to make an accurate pre-operative diagnosis which would permit optimal management of patients.[6] Cylindrical cell papillomas can also undergo malignant transformation and till 2001 only 16 such cases have been reported.[7] The coexistence of epidermoid carcinoma in both fungiform and inverted papillomas is explained by the presence of the human papilloma virus infection.[8] Other malignant sub-types rarely coexist with the papillomas.[7],[8] Among the 19 inverted papillomas that we encountered, four (21%) recurred while three (15%) developed invasive squamous cell carcinoma either synchronously or metachronously. There was only one case of cylindrical cell papilloma but even that showed a synchronous malignancy. We therefore feel that a thorough sampling of the entire material received in the laboratory is the golden rule to reach the final diagnosis. This may apply also to specimens excised as inflammatory polyps in which might lurk papillomas.[9] Besides, one may also rely on the estimation of serum squamous cell carcinoma antigen which serves as a useful biologic marker in patients with papillomas.[10] Sino-nasal carcinomas are also uncommon neoplasms.[11] Amongst the malignant epithelial tumours in this series, ′de novo′ squamous cell carcinomas were the commonest, constituting 53%. Tobacco and air pollution have been implicated in the pathogenesis of these lesions.[11],[12],[13] Among our 24 patients, only seven were chronic smokers and all were males. An unusual case in this series was squamous cell carcinoma arising from the wall of an antral cyst, as has been reported previously.[14] We also encountered two rare variants of the mundane squamous cell carcinomas, sarcomatoid and transitional types. Sarcomatoid squamous cell carcinoma[15] was seen in a 50-year-old male with right-sided nasal mass. Transitional cell carcinomas have an incidence of 2% to 11% and have a better prognosis.[16] We had three transitional carcinomas (6%), all in elderly women, and it was bilateral in one of them. Such lesions have been considered to be variants of non-keratinizing squamous carcinomas and hence, they can be associated with foci of invasive carcinoma,[16] seen in one of our cases. Adenocarcinomas of the sino-nasal tract can be broadly classified into the non-salivary and salivary types. The non-salivary adenocarcinomas represent about 10% to 20% of the sino-nasal malignancies.[17] One set of such adenocarcinomas arises from the lining epithelium or from the sero-mucous glands, termed as the non-enteric type, while the other set, ′enteric′ type is usually secondary to epithelial metaplasia in response to wood dust or other occupational hazards.[18] There were only three adenocarcinomas which we came across, an incidence of 6.5%. All were of the non-enteric type. The salivary gland-type of neoplasms are said to arise from the surface epithelium.[19] Adenoid cystic carcinoma was seen in eight of our patients (17.8%). In general, these are more frequent than the usual adenocarcinomas and are aggressive tumours, but with a better outcome as compared to similar tumours arising elsewhere in the head and neck region.[20] Muco-epidermoid carcinomas are also extremely rare,[19] with only one case in our series. There were five cases of undifferentiated sino-nasal carcinoma which is an example of a high-grade tumour[21] and one of the cases showed both intracranial extension and lymph node metastasis. They need to be distinguished from other poorly differentiated sino-nasal tumours, since they require aggressive therapy that includes a combination of craniofacial resection, chemotherapy and radiotherapy.[22] Most of our patients come to the hospital in the advanced stage with involvement of nasal and para-nasal sinuses and hence accurate determination of the site of origin is difficult. Besides, in the early stages of the disease, the signs and symptoms of the neoplastic processes are essentially similar to inflammatory pathology of the sino-nasal tract with resultant delay of diagnosis. Lack of adequate follow-up is the bane of most of the Indian studies, as is in this study too. The patients are referred from various centres across the country and then referred to cancer centres for further treatment after either biopsy or resection. REFERENCES
Copyright 2005 - Journal of Postgraduate Medicine The following images related to this document are available:Photo images[jp05010f5.jpg] [jp05010t2.jpg] [jp05010f7.jpg] [jp05010f6.jpg] [jp05010f1.jpg] [jp05010f3.jpg] [jp05010f4.jpg] [jp05010f2.jpg] [jp05010t1.jpg] |
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