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East and Central African Journal of Surgery, Vol. 15, No. 2, July-December, 2010, pp. 130-132 Case Report Female Urethral Leiomyoma: A Case Presentation AT Tefera Urologic Surgeon, St. Paul's General Specialized Hospital, Addis Ababa, Ethiopia Correspondence Address:A T Tefera, Urologic Surgeon, St. Paul's General Specialized Hospital, Addis Ababa, Ethiopia, alett2006@yahoo.com Code Number: js10047 Abstract We present a case of female urethral Leiomyoma. The mass which protruding from the urethral meatus causing dysuria and urethrorragia. Our physical examination revealed the presence of the mass on the anterior wall of the vagina protruding from the urethral meatus. Histopathological examination showed leiomyoma of the female urethra. The patient was treated surgically and the symptoms disappeared completely. Introduction Leiomyomas are benign tumors of smooth muscle origin and rarely found in the urinary tract, with only 40 cases of urethral leiomyoma reported in the literature [1],[2],[3],[4],[9] .It is more common in women between 30 and 50 years old [1],[3],[5] . The first case was reported in 1984 by Buttner [6] . There is a controversy about its dependency on estrogen hormones. Its diagnosis is made only by histopathologic examination. The topographic site of the lesion is very useful for the prognosis. Grabstald and Cols [7] classified the tumors as distal or anterior when it′s located at the distal 1/3 of the urethra, and proximal or posterior when it′s located at anterior 1/3. We report a case of leiomyoma of the female urethra with its clinicopathological characteristics. Case Report A 27 years old female patient with no history of past illness, came to our clinic presenting a mass protruding from the urethral meatus for 18 months, accompanied with dysuria and urethrorragia. On physical examination there was a polyploid and rounded mass with the size of 3.5 cm in diameter, smooth surfaced, firm with pink colour, located at the distal posterior urethra.on straining it protrudes through the urethral meatus [Figure - 1]. All investigations were normals. FNA Biopsy done revealed Epidermid cyst of the urethra. She was operated, tomour excised and specimen sent for histopahologic examination [Figure - 2]. The histopathologic examination showed a leiomyoma of the urethra. On follow after surgery the patient was found to be asymptomatic with out any abnormal finding on urologic examination. Discussion Leiomyoma is a benign tumor of mesenchimal origin, composed of smooth muscle cells found rarely in the urinary tract. Our patient histopathologic result is also same. It is known to involve in decreasing order of frequency, the kidney bladder and urethra [3],[13],[14] . Leiomyomas are 3 times more common in women between 30 and 50 years [1],[3],[5] . According to the mentioned criteria, the case presented was atypical because it appeared in a 27 years old lady.The diameter of the tumors ranged from 1 - 40 cm [2],[3],[14],[15] . The pathogenesis of leiomyoma is unknown but its growth is probably endocrine dependent, with the growth patterns and size influenced by estrogen [2],[3],[8],[15] . But our case did not have hormone dependency because as we mentioned above that she is young with no such abnormality on investigations and there is no history of oestrogen based contrceptives usage. The clinical presentations depends on the location and size of the tumor.Patient can be asymptomatic being the leiomyoma an incidental finding during gynecological examination. Common presenting symptoms are periurethral masses, urinary tract infection, hematuria,urethrrragia,dysuria and dyspareunia and even acute urine retention and acute renal failure [2],[3],[4],[10],[12] patient also had two of the mentioned clinical presentation. The clinical diagnosis is made by history, physical examination, uretherocystoscopic examination and imaging studies like transvaginal sonography, retrograde urethrography,voiding cystourethrogram and MRI [2],[3],[4],[10],[12],[13],[14] . The histopatholgic study will give the definitive diagnosis. We also reached on definitive diagnosis by histopathologic examination. The differential diagnosis of female urethral leiomyoma should be done with urethral caruncle,papilloma, urethral diverticulum, ectopic ureterocele, fibrous polyp, Gratner′s duct cyst, periurethral abscess, urethral carcinoma and other mesenchymal tumors [3],[14] . The urethral leiomyoma is treated surgically without recurrence [1],[3] . Even we treated the patient surgically and she is asymptomatic with no recurrence.The operation techniques depends on the site of the tumor.So we removed the masas through incision of the anterior vaginal wall. The prognosis of this tumor is excellent as malignant transformation has not been reported [1],[2],[3],[8] . Our patient is also doing good with no complication or recurrence after surgical therapy. Conclusion
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