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Indian Journal of Medical Microbiology, Vol. 28, No. 4, October-December, 2010, pp. 419-420 Book Review Mechanisms of Microbial Pathogenesis Reba Kanungo Editor, Indian Journal of Medical Microbiology, A-3,No 38, Rue- Labourdonnaise, Pondicherry-605006, India Date of Submission: 26-Jun-2010 Code Number: mb10129 The Tenth Sir Dorabji Tata Symposium Sir Dorabji Tata Center for Research in Tropical Diseases and the Department of Microbiology and Cell Biology, Indian Institute of Science, publish compilation of papers presented in the annual symposium. This is the tenth such publication in a series of thematic presentations. Understanding the pathogenesis of microbes is the first step toward treatment, prevention and control of infectious diseases. This book addresses several mechanisms of bacterial, viral, protozoal and fungal pathogenesis through several papers presented by researchers at the symposium. Basic research on the mechanisms of microbial survival, host parasite relationships, virulence mechanisms and ability of microbes to mutate and change antigenic expressions have been addressed by scientists. Papers presented in the symposium will help trigger research on several allied areas to study the pathogenic mechanisms in some of the most virulent microorganisms. Three major divisions of the discussions have been focused on Tuberculosis, Viral infections and Bacterial pathogens. Papers on Tuberculosis include survival of the organism in the host cell and its role in generation of adaptive immune response. Other mechanisms of immunogenicity have been discussed in papers on sub-cellular traffic, Mycobacterium-induced macrophage apoptosis, antigen-mediated activation of dendritic cells and other immunological parameters associated with host-Mycobacteria interaction. Some of the virulence mechanisms have been discussed in relation to acid resistance and homeostasis, and molecular mechanism of virulence-associated response regulator of Mycobacterium tuberculosis An interesting paper on controlling gene expression in vitro and in vivo will encourage research on control mechanisms and drug targets. In a detailed description on pathogenesis of enterovirus, authors from Stony Brook University have addressed classification, human diseases, molecular biology and lifecycle and determinants of enterovirus pathogenesis. Epidemiology and global polio eradication program adds to the relevance of laboratory research translating into prevention strategies with innovative genetic studies. Papilloma virus oncogene expression in cervical cancer has been discussed in a small chapter. Two papers on Hepatitis C discuss functions of NS5A protein and the role of human La protein in translation and replication of the virus. These two papers highlight some of the basic mechanisms of Hepatitis C pathogenesis. A paper on Hepatitis E virus discusses the structural and regulatory function during viral pathogenesis. Rhabdovirus pathogenesis has been addressed through studies on mechanism in Chandipura virus as a prototype with molecular approach to understanding the process. Flavivirus group including Dengue, West Nile and Japanese Encephalitis (JE) have been discussed in the subsequent papers. Basic research on therapeutic intervention of JE infection by researchers from National Brain Research Institute opens new areas for future work to understand the pathogenesis of JE virus which has become endemic in certain parts of the country, with substantial morbidity and mortality reported every year. Another endemic infection reported annually is that caused by Dengue virus. Paper on Dengue Hemorrhagic Fever is another interesting discussion of in vitro studies, giving an insight into its mechanism. Three bacterial pathogens which have found place in the discussions are Salmonella and Neisseria meningitides and Helicobacter pylori. The former's role in host sensing and regulation of inflammation, lysosomal escape mechanism are basic research on pathogenesis of Salmonella. Exploiting the commensalism of N. meningitides and vaccine prospects through complete genomic sequence for new vaccine antigens is the highlight of the papers on bacterial pathogens. Reason for persistence of malaria despite the control measures requires looking into the parasite's virulence and replication mechanisms. This has been addressed through a study on Plamodium falciparum. Treatment approaches are researched through targeted antimalarial agents. The symposium also forms a platform for presentation of abstracts, the best of which are published in these series. These abstracts represent some of the basic research undertaken by scientists to understand the pathogenesis and virulence mechanisms of microorganisms. The book on Mechanisms of Microbial Pathogenesis is a compilation of high level of basic research papers and discussion which will be found useful and interesting to all those who are pursuing research or are in search of material for further studies. References cited at the end of each paper are a good source for readers to access similar work. Editors D. Raghunath and V. Nagaraja must be appreciated for regularly publishing compilation of the lectures and abstracts of scientific papers presented in the annual Sir Dorabjee Tata Symposium. This book is recommended for individuals with an interest in basic knowledge and research in biomedical science. Copyright 2010 - Indian Journal of Medical Microbiology |
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