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Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 13, Num. 2, 2006, pp. 1-6
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Malaysian
Journal
of
Medical
Sciences,
Vol.
13,
No.
2,
July
2006,
pp. 1-6
EDITORIAL
OF
ROOTS,
BARKS,
PARACETAMOL
AND
EDTA
Abdul Hamid Abdul Kadir
Orthopaedic
Surgeon,
Assunta
Hospital
Petaling
Jaya,
Selangor,
Malaysia
Correspondence : Dr.
Abdul
Hamid
Abdul
Kadir
MBBS(Singapore),
FRCS(Edin),
MChOrth
(Liverpool)
Orthopaedic
Surgeon,
Assunta
Hospital
Petaling
Jaya,
Selangor,
Malaysia
Tel:
+
609-76807000
Fax:
+609-77832458
Email:
abdulhamid@assunta.com.my
Code
Number:
mj06015
Key words : traditional medicine, homeopahty, Malaysia
Traditional native medicine has existed throughout the world from time immemorial. Early humans had sought cures for illness by using plants, animal parts, and mineral and as a species have survived. It can even be said that the forest, the home to our forebears, served as a veritable pharmaceutical depot as well. Physical evidence of use of herbal remedies goes back some 60,000 years to a burial site of a Neanderthal man uncovered in 1960 (1)
The Penans in Sarawak even today scoff at visitors bringing along paracetamol and anti-diarrhoeals when they go jungle trekking with them, saying that all the medicine they will ever need are in abundance around them : in the leaves and barks of trees.
All cultures have long folk medicine histories that include the use of plants. Even in ancient cultures, people methodically and scientifically collected information on herbs and developed welldefined herbal pharmacopoeias.
The World Health Organization (WHO) estimates that 4 billion people-80 percent of the world population-use herbal medicine for some aspect of primary health care (Farnsworth et al., 1985). Herbal medicine is a major component in all indigenous peoples' traditional medicine and is a common element in Ayurvedic, homeopathic, naturopathic, traditional oriental, and Native American Indian medicine.
The sophistication of herbal remedies used around the world varies with the technological advancement of countries that produce and use them. These remedies range from medicinal teas and crude tablets used in traditional medicine to concentrated, standardized extracts produced in modern pharmaceutical facilities and used in modern medical systems under a physician's supervision.
It would be appropriate to review some of these traditional medical practices.
Traditional Chinese Medicine
Chinese traditional medicine has a history of thousands of years and is based on two doctrines: yin and yang and the Five Elements (metal, wood, water, fire and earth). In medicine everything is classified according to yin and yang. On the human body, the skin is yang and the interior is yin. The heart and liver are yang organs and the spleen, lungs and kidneys are yin organs. In the healthy state, the human body is made up of a harmonious mixture of the Five Elements.
The earliest Chinese records of illnesses, medicine and treatment were found inscribed on oracle bones (tortoise shells and animal bones) some three thousand years ago (Shang Dynasty: 1766 to 1122 BC), and would represent the earliest medical information.
The earliest written evidence of the medicinal use of herbs in China consists of a corpus of 11 medical works recovered from a burial site in Hunan province. The burial itself is dated 168 B.C., and the texts (written on silk) appear to have been composed before the end of the 3rd century B.C. Some of the texts discuss exercise, diet, and channel therapy (in the form of moxibustion).
The largest, clearest, and most important of these manuscripts, called by its discoverers Prescriptions for Fifty-Two Ailments, is predominantly a pharmacological work. More than 250 medicinal substances are named. Most are substances derived from herbs and wood; grains, legumes, fruits, vegetables, and animal parts are also mentioned. Underlying this entire text is the view that disease is the manifestation of evil spirits, ghosts, and demons that must be repelled by incantation, rituals, and spells in addition to herbal remedies.
Chinese
herbal
medicinesare
derived
mostly
from
plants
(ginseng
roots,
ginger
rhizome,
foxglove
roots,
chrysanthemum
flower,
cinnamon
roots,
garlic
bulb
to
name
a
few)
and
also
from
animals,
minerals
and
fungi.
During
the
Han
Dynasty
(which
ended
in
the
2 nd century
AD),
365
medicines
were
recognised.
Today,
there
are
more
than
5000
Chinese
medicines
and
the sinseh will
prescribe
medicine
according
to
their
diagnoses,
which
includes
an
in-depth
interview
of
the
patient,
as
well
as
examination
of
the
patient's
pulse,
smelling
of
the
breath
and
inspection
of
the
tongue.
By the later Han Dynasty (25-220 A.D.), medicine had changed dramatically in China. People grew more confident of their ability to observe and understand the natural world and believed that health and disease were subject to the principles of natural order. However, herbs still played an important part in successive systems of medicine. The Classic of the Materia Medica, compiled no earlier than the 1st century A.D. by unknown authors, was the first Chinese book to focus on the description of individual herbs. It includes 252 botanical substances, 45 mineral substances, and 67 animal-derived substances. For each herb there is a description of its medicinal effect, usually in terms of symptoms. Reference is made to the proper method of preparation, and toxicities are noted (2).
In Malaysia, the numerous licensed Chinese herbal medicine outlets in cities and towns testify to their popularity not only among ethnic Chinese, but also other races.
Ayurvedic Medicine
Ayurvedic medicine, or Ayurveda, comprising treatments which are primarily dietary and herbal, is an “alternative” medical practice that claims it is the traditional medicine of India. Ayurveda is based on two Sanskrit terms: ayu meaning life and veda meaning knowledge or science. Ayurveda, the science of life, prevention and longevity is the oldest and most holistic or comprehensive medical system available.
The principal Ayurvedic book on internal medicine, the Characka Samhita, describes 582 herbs (3). The main book on surgery, the Sushruta Samhita, lists some 600 herbal remedies. Most experts agree that these written records are at least 2,000 years old.
Ayurvedic treatments are primarily of herbal origin (teakwood and bark, gooseberry, kurroa rhizomes, neem, etc.), and also require dietary habits. The metaphysical physiology of Ayurveda dictates when to eat and when not to eat spicy foods, sweet foods, honey, nuts, meat and dairy products.
Meditation is also a significant therapy in Ayurveda. Except for the benefits of relaxation and meditation, there is no scientific evidence to support any of the many astounding claims made on behalf of Ayurvedic medicine.
Ayurveda is said to have been practised for some 5,000 years, and in spite of its worldwide acceptance, what it considers to be knowledge or science may not coincide with the most updated information available to Western medicine. However, Ayurvedic medicine is recognised by WHO.
Bomohs
Traditional healing in Malaysia is not limited to utilizing therapeutic, physical means or to prescribing a dose of medicine or herbs; it is a holistic approach that caters for the spiritual and psychological needs of patients, together with all other modes of treatment.
A folk medicine practitioner in Malaysia is called a bomoh, dukun, or pawang according to the period a student spends studying, and remains indispensable even today. The studies undertaken, which equip practitioners to prescribe proper medication to patients, cover the philosophy of life; therapeutic usages of herbs, metals, and animals parts; and the relation between the above disciplines and human beings and their lives. Folk medicine practitioners, especially the elders who are called touks, are treated with great respect, particularly in rural societies.
Knowledge of traditional healing is usually passed on from one member of the family to another, allowing them to practise folk medicine as a career or as a secondary occupation. The healer usually chooses a younger family member he deems most suitable to pass his knowledge to.
Bomohs start their education by studying the sciences of the Shariah (Islamic law), including jurisprudence, monotheism, and Sufism, which are necessary for the bomohs not only to practice but also to get the recognition of the Muslim communities in which they live; especially with the prevalence of Islamic awakening, these communities will not recognize bomohs who have no knowledge of medical-related Shariah injunctions, without which bomohs are bound to get entangled in superstition and trickery.
The bomoh's know-how must be seen on a positive note as it is based on a repository of knowledge that had expanded generations after generations. A major portion of the Malay medicine can be found in the ‘tib' literature that provide the remedies for the ailments (4)
The
bomoh
uses
some
4,000
extracts
from
herbs,
animals,
metals,
and
liquids.
While
some
herbal
remedies
are
available
on
the
market
and
ready
for
consumption,
others
are
homemade;
anyone
with
general
knowledge
of
traditional
medicine
can
prepare
a
few
simple
blends
or
medicinal
solutions
whose
formulas
are
well
known.
Because
of
the
trust
patients
place
in
their
practitioner,
they
prefer
getting
their
medication
from
him
rather
than
buying
it
because
he
prepares
it
himself,
sometimes
in
their
presence.
The Malaysian herbal industry has grown in the Modern Age with the introduction of home-based and small commercial factories, as well as factories owned by big companies, which prepare medicines using cutting-edge technologies throughout the process, which includes the mixing, grinding or squeezing, and packaging of herbs. Some of these companies are renowned for using quality control methods and for testing their products before obtaining a permit from the Ministry of Health to market them.
On the other hand, some companies manufacture and sell their products without obtaining the Ministry's permission. These products can be effective, ineffective, or even harmful when manufacturers use unethical practices Since there are remedies that cater for specific target markets such as single or married women, many manufacturers, driven by greed, use unethical practices to produce these remedies and promote them among city dwellers.
Homeopathy
The early 1800's were a time of great transition in medicine. Whereas the standard, allopathic form of treatment was dominant at the turn of that century, there was renewed interest in traditional and alternative therapies. The two most popular alternatives to the orthodox practice were herbal medicine and Homeopathy.
Samuel Hahnemann, a German physician who lived around 1800, is credited with founding homeopathy, but the basic principles of homeopathy have been recorded in the history of numerous ancient and primitive peoples, from Asia to the Incas and Aztecs, to the Egyptians.
Homeopathy is one of the fastest-growing alternative medicines available today. By triggering the body's own self-healing abilities, homeopathic remedies are believed by its proponents to be a safe and effective way to treat everyday ailments as well as acute and chronic symptoms of mind and body (5).
Homeopathy rests on three principles:
- The Law of Similars which states that a disease should be treated by a medicine producing symptoms in a healthy person similar to those the patient is experiencing.
- The use of a single medicine to treatall symptoms the patient is expressing - mental, emotional, and physical.
- The use of a minimum dose. The homeopath first prescribes a small number of doses of the selected medicine. Then, after observation of the effects, a regimen of even smaller dosages is established.
Homeopathic medicines are indeed powerful tools but they are not effective in treating all diseased states. Some conditions do not respond to microdoses because they require surgical intervention, others require immediate and certain relief of symptoms, others are addressed by simple nutritional or lifestyle changes, still others are relieved only upon reduced exposure to certain environmental stresses - and then, there are those who don't experience improvement from homeopathic medicine for unknown reasons (5). Regulatory Status of Herbal Medicine Worldwide Despite the importance of plant discoveries in the evolution of medicine, some regulatory bodies such as the U.S. Food and Drug Administration (FDA) - the main U.S. regulatory agency for food and drugs - consider herbal remedies to be worthless or potentially dangerous (6).
Despite FDA's skepticism about herbal remedies, a growing number of Americans are again becoming interested in herbal preparations.
Many fruits and vegetables are believed to have prophylactic and preventive properties on many common diseases and influence their intake by members of the public. The list is exhausting: blueberries, cabbage, cantaloupe, carrots, garlic, and oats are all believed to combat cancer; oats, garlic, artichokes, avocadoes and figs lower cholesterol; honey aids digestion and fights allergy, wheat germ and bran combat colon cancer, and the lowly onion combats cancer, reduces risk of heart attacks and lowers cholesterol.
Well
into
the
20th
century
much
of
the
pharmacopoeia
of
scientific
medicine
was
derived
from
the
herbal
lore
of
native
peoples.
Many
drugs,
including
strychnine,
aspirin,
vincristine,
taxol,
curare,
and
ergot,
are
of
herbal
origin.
About
onequarter
of
the
prescription
drugs
dispensed
by
community
pharmacies
in
the
United
States
contain
at
least
one
active
ingredient
derived
from
plant
material
(7).
Chelation Therapy & EDTA
Compared with these ancient traditional medicines in the treatment of diseases, so-called alternative treatment employing chelation and colonic washouts are indeed very recent.
Chelation therapy with EDTA first came into practice in 1960 in Europe and the USA, and in 1973 the American College for Advancement in Medicine (ACAM) was founded to focus primarily on the promotion of chelation therapy.
EDTA is the short form for Disodium Ethylene-diamine-tetra-acetic acid, the organic chemical (amino acid) which is commonly used in chelation therapy. Chelation therapy is a series of intravenous infusions containing EDTA which my be used to treat iron-load from multiple blood transfusions, lead poisoning and other heavy metal (mercury, copper, aluminium, nickel, cobalt, zinc, cadmium, manganese, magnesium and calcium) poisoning.
It must be stated at this juncture that heavy metal poisoning in the normal human population living in normal environment and consuming normal food is extremely rare. It is extremely rare in Malaysia.
EDTA, or its sodium salt, is a chelating agent, forming coordination compounds with most metal ions, such as calcium, magnesium or copper. Its industrial use is in determination of water hardness and as a water softener. It is also used in photography as a component of bleach-fix used to dissolve elemental silver produced during development. It is also used as a soil conditioner to allow some plants to grow in base rich soils.
In medical and laboratory practice EDTA is used as an anti-coagulant or anti-clotting additive. When blood is taken for tests from patients, EDTA is added to prevent the blood sample from clotting, by scavenging the calcium from the sample, to facilitate various tests to be carried out on the unclotted, whole blood.
After EDTA was found effective in chelating and removing toxic metals, like lead, from the blood, some scientists postulated that hardened arteries could be softened if the calcium in their walls was removed.
This formed the basis for claims that chelation therapy is effective against atherosclerosis, coronary heart disease, and peripheral vascular disease. Its supposed benefits include increased collateral blood circulation, decreased blood viscosity, improved cell membrane function, decreased arterial vasospasm, decreased free radical formation, inhibition of the aging process, reversal of atherosclerosis, decrease in angina, reversal of gangrene, improvement of skin color, and healing of diabetic ulcers.
It is also claimed that chelation is effective against arthritis; multiple sclerosis; Parkinson's disease; psoriasis; Alzheimer's disease; and problems with vision, hearing, smell, muscle coordination, and sexual potency.
These claims have never been tested by scientific methods or found to be effective in the treatment of such a multitude of diseases.
Those who practise chelation therapy administer EDTA either through the intravenous route or in capsules taken orally.
There are instances to show that there indeed are early and late complications with chelation therapy, like the heavy loss in the urine of trace metals like zinc which has an important role in strengthening the body's immune function. Loss of large amounts of calcium through chelation is also believed to create loss of calcium from bone.
Evidence-based Medicine
On the other hand, the allopathic doctors, or registered medical practitioners, practise evidence-based medicine, by which is implied that the system of treatment of their patients is based on well-established and sound scientific studies and principles of therapeutics, and their efficacy to control, treat or modify diseases. The system of therapeutics so advocated can be, and is being practised safely universally with predictable results in the vast majority of patients.
The medications used by allopathic doctors are very specific for well defined disease conditions and the composition, use and adverse reactions are monitored by authorities established for such specific purposes. On any adverse reports, the products are quickly taken off the shelves.
Chelation therapy with EDTA would come under the category of complementary medicine because its widespread use by some registered medical practitioners is not what it had been used originally on evidence-based therapeutic criterion.
By prescribing various supplements, like large amounts of Vitamin C and several B vitamins during chelation therapy for treatment of diseases for which they have not been proven to be effective or not conventionally used, or, in other words, where there has been no scientific evidence adduced for their effectiveness and efficacy in such diseases, registered medical practitioners are in fact practising complementary medicine. The
Burden of Proof
The onus to prove that chelation therapy, and other similar complementary medical practices, is a sound, repeatable system of therapeutics rests heavily on the proponents of complementary medicine. It is not enough to produce anecdotal testimony from patients.
Medical
practitioners
who
treat
their
patients
with
chelation
therapy
would
have
to
show
scientific
evidence
that
their
patients
have
improved,
not
in
the
short
term
but
more
importantly,
in
the
long
term
as
well.
It
has
to
be
scientifically
proven
that
chelation
could
alter
the
progress
of
atherosclerosis,
that
occluded
blood
vessels
could
be
cleared,
that
plaque
deposits
could
be
reduced,
and
that
hardened
arteries
could
be
'softened'.
They have to produce carefully documented case reports with long-term follow-up, comparisons of angiograms or ultrasound tests before and after chelation, and data from autopsies of former patients.
It is reported that doctors practising chelation therapy have published no such data. The few well-designed studies that have addressed the efficacy of chelation for atherosclerotic diseases have been carried out by medical scientists in FDA, American Heart Association, American Medical Association, American College of Physicians, and the University of Calgary, to name a few.
Without exception, these studies by reputable bodies found no evidence that chelation worked.
There are many patients in Malaysia, who claim to have benefitted from chelation therapy and some of them have written testimonials and have volunteered to give evidence in person. Many others who have not benefitted remain silent sufferers. Because we do not hear from them in the media or in the courts of law, it does not mean that all patients who had undergone chelation therapy have recovered completely from their illnesses.
Medical Act 1971
To
understand
the
practice
by
registered
medical
practitioners
of
complementary
and
alternative
treatments,
one
has
to
look
first
at
the
Medical
Act
1971
and
then
at
other
supporting
material
on
the
subjects
of
allopathic
and
complementary
medicine.
Section
34
(1)
of
the
Medical
Act
1971,
in
the
subsection
'Malay,
Chinese,
Indian
or
other
native
methods
of
therapeutics',
states:
'Subject
to
the
provisions
of
subsection
(2)
and
regulations
made
under
this
Act,
nothing
in
this
Act
shall
be
deemed
to
affect
the
right
of
any
person,
not
being
a
person
taking
or
using
any
name,
title,
addition
or
description
calculated
to
induce
any
person
to
believe
that
he
is
qualified
to
practise
medicine
or
surgery
according
to
modern
scientific
methods,
to
practise
systems
of
therapeutics
according
to
purely
Malay,
Chinese,
Indian
or
other
native
methods,
and
to
demand
and
recover
reasonable
charges
in
respect
of
such
practice'.
In brief, the Act does not restrict any person from practising native/traditional/complementary medicine, so long as the person is not a medical practitioner registered under the provisions of the Medical Act 1971 (8).
Whether
complementary
and/or
traditional
medicine
is
included
by
definition
in
the
'system
of
therapeutics
according
to
purely
Malay,
Chinese,
Indian
or
other
native
methods'
is
open
to
interpretation.
However,
it
is
common
knowledge
that
those
practising
non-Western
complementary
system
of
therapeutics
normally
use
both
herbs
and
additionally
some
allopathic
medications.
The
use
of
allopathic
medications
by
such
practitioners
is
in
most
instances
for
diseases
and
indications
not
usually
or
conventionally
employed
in
the
practice
of
evidence-based
Western
medicine.
The Medical Act 1971 has no jurisdiction over non-registered or non-medical persons who choose to practise complementary medicine or native medicine or traditional medicine.
But registered medical practitioners who practise such traditional or complementary medicine would clearly be misleading the members of the public, and presenting themselves as trained, registered and certified to practise all systems of therapeutics, thereby adding credibility to their practice.
The
medical
profession
may
view
native
medicine
as
one
ancient
remedy
which
may
not
possibly
be
subjected
to
the
rigorous
demands
of
scientific
study
and
analysis
to
seek
and
obtain
evidence
base,
and
those
who
practise
such
medicine
as
not
possibly
registrable
or
be
subjected
to
strict
regulatory
procedures.
However,
the
same
approach
cannot
be
taken
with
registered
medical
practitioners,
trained
in
conventional
Western
medicine
and
bound
by
its
fairly
strict
codes
of
professional
conduct,
who
should
deviate
from
such
practice
and
treat
their
patients
with
native
medicine.
This
is
on
the
understanding
that
patients
who
come
to
a
registered
medical
practitioner
expect
Western
medicine,
and
should
not
be
misled
into
believing
that
it
is
safe
to
take
whatever
native
medicine
that
the
good
doctor
prescribes.
No doubt there may be a place in the future for so-called integrative medicine, but let us not ignore the fact that even in the West and advanced countries where such practice is finding a niche, there is widespread opposition and anti-lobby and it cannot be dismissed simply as professional turf war. It is a question of what is established and proven system of therapy and what is not (9).
Responsibility of the Ministry of Health
The Ministry of Health is said to be “keeping an open mind” about the practice of complementary and traditional medicine in Malaysia. It is a fact that the Ministry and the Universities are currently looking into ways and means of regulating traditional and herbal medicine practice by analysing the hundreds of such medications being sold openly in this country. It is a multi-million dollar business and obviously the government has more than a passing interest in it.
Interestingly, there is a proposal by the Ministry of Health that traditional practitioners, like sinsehs, bomohs and ayurvedic physicians may be allowed in the near future to practise in government hospitals and patients may be allowed to choose either conventional Western medicine, or one or more of the above traditional medicine.
The Medical Act 1971 and the Code of Professional Conduct of the MMC clearly do not allow any professional association between registered medical practitioners and traditional practitioners, and it is hoped that this proposal by the government will not be carried through.
Members of the public have the right to choose whatever system of treatment they prefer for whatever reason, but it is also the mandated right of the Ministry of Health to set the standards of health care, and to demonstrate its duty and responsibility to point out to the public the various pitfalls in any system and the unpleasant consequences.
Failure to do so would be a failure to provide proper health care and to exercise social responsibility for the welfare and well- being of the Malaysian public.
References
- Solecki, R.S. Shanidar IV, A Neanderthal flower burial of northern Iraq. Science 1975; 190: 880.
- Bensky D and A Gamble. Chinese Herbal Medicine Materia Medica. Revised Edition Seattle. Eastland Press, 1993.
- The Healing Hand Man and wound in the ancient world. Majno,GM,ed, Harvard University Press, Cambridge, Massachusetts, 1975.
- Hashim Awang AR. Perbomohan Melayu : Kemana Akhirnya? Journal Persatuan Mazium Malaysia 15, 1996: 56-66
- Dana Ullman MPH. Discovery Homeopathy: Medicine for the 21st century, Berkeley: North Atlantic Books 1991.
- Snider, S Beware the unknown brew: herbal teas and toxic. FDA consumer 1991: 31-3.
- Farnsworth N.R and R. W. Morris, Higher plants the sleeping giant of drug development, AM. J. Pharm. Educ. 1976; 148 : 46-52.
- Medical Act (Act 50) & Regulations (As at 5 th September 2005) International law Book Service. 2005. Syarikat Percetakan Ihsan, Selangor 1971.
- Raden Sanusi HR, Werner R. The role of traditional healers in the provision of health care and family planning services: Malay traditional and indigenous medicine. Malaysian J Reprod Health 3, 1985; 82-9
© Copyright
2006
-
Malaysian
Journal
of
Medical
Science
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