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Neurology India
Medknow Publications on behalf of the Neurological Society of India
ISSN: 0028-3886 EISSN: 1998-4022
Vol. 52, Num. 2, 2004, pp. 271-271
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Neurology India, Vol. 52, No. 2, April-June, 2004, pp. 271
Letter To Editor
Satoyoshi syndrome: Comments
Varkey Boby M
Mayo Clinic , Rochester, MN
Correspondence Address:Mayo Clinic , Rochester, MN
Code Number: ni04087
Sir,
I read with interest a case report of Satoyoshi syndrome by Ashalatha et al.[1] The similarity with a ′jerking stiff-man syndrome′ -a variant of stiff-man syndrome (SMS) is striking. Distal limb involvement, myoclonic jerking, board-like muscles, stimulus-evoked spasms, endocrinopathies, vitiligo, pernicious anemia and sicca syndrome can also be seen in jerking SMS.[2] Continuous motor unit activity (CMUA) is necessary to diagnose this variant but can sometimes be elusive and manifest only in the paraspinal muscles.[3] Earlier this year, anti-GAD antibodies were described with Satoyoshi syndrome.[4] This validates the auto-immune nature of this disorder and suggests that it might be a variant of stiff-man syndrome. In both cases, a partial response to immunomodulating agents such as immuno-globulin or high dose steroids may be seen. I wonder if anti-GAD antibodies could be tested in the described case as well.
References
| 1. | Ashalatha R, Kishore A, Sarada C, Nair MD. Satayoshi syndrome. Neurol India 2004;52:94-5. Back to cited text no. 1 [PUBMED] [FULLTEXT] |
| 2. | Meinck HM, Thompson PD. Stiff man syndrome and related conditions. Mov Disord. 2002;17:853-66. Back to cited text no. 2 [PUBMED] [FULLTEXT] |
| 3. | Brown P, Marsden CD. The stiff man and stiff man plus syndromes.J Neurol. 1999;246:648-52. Back to cited text no. 3 [PUBMED] [FULLTEXT] |
| 4. | Drost G, Verrips A, Hooijkaas H, Zwarts M. Glutamic acid decarboxylase antibodies in Satoyoshi syndrome. Ann Neurol. 2004;55:450-1. Back to cited text no. 4 [PUBMED] [FULLTEXT] |
Copyright 2004 - Neurology India
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