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Neurology India, Vol. 52, No. 3, July-September, 2004, pp. 393-394 Letter To Editor Ventriculo-peritoneal shunt infection by mycobacterium fortuitum in an adult Viswanathan Roopa, Bhagwati SN, Iyer Viswanathan, Newalkar Prashant Departments of Microbiology, Bombay Hospital and Medical Research Centre
Correspondence Address:Departments of Microbiology, Bombay Hospital and Medical Research Centre Code Number: ni04132 Sir, Provisional diagnosis was pneumonia and infected VP shunt. Investigations done showed: Hemoglobin-12.2 gm%, CBC-9820 (Neutrophils-76%, lymphocytes-24%). Cerebrospinal fluid (CSF) showed proteins-56 gm% and White blood cells (WBC) count of 20 (30% polymorphs, 65% lymphocytes). Pus sent for culture and sensitivity yielded no growth. But Ziehl Neelsen′s stain for pus samples showed acid fast bacilli following which, culture on Lowenstein Jensen′s medium yielded a growth of M. fortuitum in a period of 7 days and anti-tuberculosis drug susceptibility testing showed sensitivity to Kanamycin and Ciprofloxacin but resistance to standard drugs namely Isoniazid, Rifampicin, Streptomycin, Ethambutol, Pyrazinamide, Ofloxacin, Amikacin, Sparfloxacin. The patient was treated with 1 gram of intramuscular Kanamycin once a day for two months and 200ml of intravenous Ciprofloxacin twice a day for three weeks followed by oral 500 mg twice daily for six months. On discharge, the patient was afebrile, conscious, obeying, moving all four limbs. After six months, there was resolution of lesions and no systemic symptoms. Mycobacterium fortuitum is an environmental, rapidly growing organism that is found in soil, dust and water. It can colonize without causing invasive disease. It has been implicated in soft tissue infections, osteomyelitis and postoperative infections and injection abscesses.[1] M. fortuitum infections have been reported in various surgical procedures.[2],[3],[4] M. fortuitum very rarely causes Central Nervous System (CNS) infection. VP shunt infection by M. fortuitum was unheard of till Midani et al[5] reported it in a 13-year-old Spina bifida patient. CNS infection by M. fortuitum occurs due to trauma, contamination during surgery or communication with an infected focus. Contamination during surgery is what we speculate for the VP shunt infection in our patient. Amikacin seems to have been successfully used for the treatment of M. fortuitum infection. But in vitro drug susceptibility using Lowenstein Jensen′s medium by resistance ratio method in our case showed resistance to Amikacin and standard anti-tuberculosis drugs. Kanamycin and Ciprofloxacin were the drugs found to be effective in vitro, that were used for the treatment in our patient after the removal of the shunt and after surgical debridement which is the mainstay of treatment in skin and soft tissue infections. Thus the possibility of contamination with M. fortuitum must be kept in mind while placing ventriculo-peritoneal shunt. So utmost care with regards to aseptic precautions is necessary. REFERENCES
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