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Neurology India, Vol. 58, No. 4, July-August, 2010, pp. 596-598 Topic of the Issue: Letter to Editor Unilateral diaphragmatic paralysis following dengue infection Ansari MK, Jha Sanjeev, Nath Alok Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh Correspondence Address:Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, drsjha@rediffmail.com Date of Acceptance: 17-Jul-2010 Code Number: ni10156 PMID: 20739800 DOI: 10.4103/0028-3886.68662 Sir, Dengue is the most common arboviral infection in tropical and sub-tropical climates. Clinical presentation varies from a severe flu-like illness to a potentially lethal dengue hemorrhagic fever. Various neurological manifestations of dengue include myositis, polyradiculopathy and Guillain-Barre syndrome. [1],[2],[3] Isolated phrenic neuropathy and diaphragmatic paralysis following dengue is extremely rare and only a single such association has been described. [4] We report the second such patient. A 38-year-old school teacher presented with fever, rashes and generalized body pains of 4 days duration. On examination, he was febrile (102°F), with a pulse of 128/min and a blood pressure of 120/78 mmHg. The rash was macular and blanching and generalized. Petechiae were present over the thighs and abdomen. Neurological examination at this stage was essentially normal. Total platelet counts were 7,000/mm 3 and total leucocyte count was 10,200/mm 3 with lymphocyte predominance. Serology for dengue IgG and IgM was positive. Results of the liver function tests are: total bilirubin 1.07 mg/dl; SGOT 262 U/L, SGPT 85 U/L; alkaline phosphatase 318 U/L. Coagulation profile and renal functions were normal. He was given supportive care and transfusion of platelet concentrates. Within 6 days of onset of symptoms, he had a significant relief of his ailments. His hospital stay was uneventful, except for body ache, particularly along the right shoulder and interscapular region, which responded to oral analgesics. After 1 week of a symptom-free interval, he developed shortness of breath and chest discomfort on physical exertion and talking, especially while delivering lectures to his students. These symptoms were nonprogressive, but persisted for 1 month when he was re-hospitalized for evaluation. General physical examination was unremarkable and there were no focal neurological deficits. The X-ray of chest showed elevated right hemidiaphragm [Figure - 1]. Fluoroscopy for diaphragmatic movements demonstrated minimal excursion of right diaphragm with no paradoxical motion on sniff test [Figure - 2]a and b. Electrodiagnostic studies revealed nonrecordable compound muscle action potential (CMAP) from right phrenic nerve [Figure - 3] and [Figure - 4]. There was no electrophysiological evidence of involvement of other components of the right brachial plexus. The pulmonary function test (PFT) in the sitting position was suggestive of restrictive pattern. The contrast-enhanced computed tomography of thorax was normal. Post dengue, right phrenic neuropathy was considered and he was managed with oral steroids and supervised chest physiotherapy. He also received intravenous immunoglobulins for 5 days. At 4 weeks of follow-up he had significant relief in symptoms. Repeat PFTs showed significant increase in expiratory forced vital capacity and forced expiratory volume during the first second. Repeat phrenic nerve conduction study showed low amplitude but recordable right phrenic nerve CMAP [Figure - 3] and [Figure - 4]. Diaphragmatic paralysis is more common than clinically recognized and the etiology remains unidentified in more than two-third of the cases. [5] Post viral neuropathy and phrenic nerve involvement have been described following several viral infections like herpes zoster, poliovirus, West Nile virus and human immunodeficiency virus infections. [6],[7],[8],[9] Our patient had dengue infection complicated by right phrenic neuropathy, resulting in hemidiaphragmatic paralysis and respiratory insufficiency. Neurological and electrophysiological evaluation revealed only isolated right phrenic neuropathy and no evidence of brachial plexus involvement. The initial symptoms of pain along the right shoulder and interscapular region might have been due to brachial plexus involvement. However, the electrodiagnostic tests performed after 1 month of onset of these symptoms were not suggestive of brachial plexus involvement, except for right phrenic neuropathy. It is possible that this patient might have had brachial plexus involvement initially, where several of the features like weakness and wasting in the distribution of single or multiple motor nerves are absent or not readily recognized. [10],[11],[12] Phrenic nerve palsy has been described as an isolated involvement in brachial neuritis. [10] Clinical course and management of postinfection phrenic neuropathy remains inconclusive. In the earlier reported case, the course was either benign or associated with poor outcome requiring prolonged mechanical ventilation. [8],[9] Considering the possible pathogenic mechanism being immune-mediated inflammatory reaction, these patients were given intravenous immunoglobulin. [6],[13] References
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