Neurology India Medknow Publications on behalf of the Neurological Society of India ISSN: 0028-3886 EISSN: 1998-4022 Vol. 59, Num. 2, 2011, pp. 323-323

Neurology India, Vol. 59, No. 2, March-April, 2011, pp. 323

Correspondence

Tc-99m ethylcysteinate dimer SPECT in the differential diagnosis of dementias

V Wiwanitkit

Wiwanitkit House, Bangkhae, Bangkok - 10160, Thailand

Correspondence Address: V Wiwanitkit, Wiwanitkit House, Bangkhae, Bangkok - 10160, Thailand, wviroj@yahoo.com

Date of Submission: 08-Feb-2011
Date of Decision: 22-Mar-2011
Date of Acceptance: 22-Mar-2011

Code Number: ni11099

PMID: 21483157

DOI: 10.4103/0028-3886.79164

Sir,

I read with interest the article by Tripathi et al^[1] on Tc-99m ethylcysteinate dimer SPECT in the differential diagnosis of dementias with great interest. The authors concluded that Tc-99m ethylcysteinate dimer brain perfusion SPECT is useful in the differential diagnosis of dementia with particular reference to Alzheimer's disease (AD) as well as frontotemporal dementia (FTD). I would like to share some of my views on this topic. First, although the diagnostic criterion for various diseases is appropriate, I have an important concern for the small number of subjects in each group. Indeed, in case with enlarged ventricle, the false positive can be expected. ^[2] Second, the cost-effectiveness of this new approach is interesting. If possible, data on this aspect may be given.

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