The Agbiotech Bulletin Volume 3 Issue 8, August, 1995
Code Number: NL95026
Sizes of Files:
Text: 50K
No associated graphics
Biotech Research at Foundation of Economy
While plant biotechnology may not be as glamorous as, say, a
new biotech drug, it effects the very foundations of the
Canadian economy, according to Dr. Michael Smith.
Smith is Director of the Biotechnology Laboratory at the
University of British Columbia as well as scientific leader of
PENCE, the Protein Engineering Network of Centres of
Excellence (one of 15 such networks in Canada). He is also
recipient of the 1993 Nobel Prize for Chemistry for his role
in developing site-directed mutagenesis. Now in widespread
use, this technique is employed by molecular biologists to
study the relationship between the structure and function of
proteins and has spawned the new discipline of protein
engineering.
Smith says plant biotech has been the poor cousin in
terms of government funding. He gives the example of PENCE and
its counterparts of about 150 applications for the various
scientific disciplines, only 15 were funded, none of which
included those dealing with plant molecular genetics, plant
biology or plant biotechnology.
"As far as I'm concerned Canada ought to be investing much
more in plant biotechnology and forestry biotechnology because
those two things are still the underpinning of our commerce
and industry."
Despite this, public funding has often been targeted to human,
animal, bacterial or viral molecular genetics. This is evident
in the disparity between medically-oriented research (funded
through the Medical Research Council) and plant research
(funded through the National Sciences and Engineering Research
Council).
"The level of money for NSERC was nowhere near as high as from
the MRC," Smith says. "Of course it costs just as much
money to do genetic engineering on a plant as it does on a
rat. It means we really haven't invested enough in that area
(plant biotech).
However, Smith says the problem is not unique to
Canada. Much basic research gets funding because of its
medical applications, due to a strong emotional tie-in that
isn't there in plant research. This is an unwise course for
Canada to follow, as this country's economy depends so much on
what it grows, whether it be in field or forest. He recommends
more investment in basic plant, tree and general agbiotech
research to keep ideas in the pipeline, ready to be developed
into new products.
According to Smith, genome mapping would be a good
place to start. He notes that other countries are aggressively
pursuing such projects on species intimately tied to the
domestic economy. For example, New Zealand is mapping the
sheep genome, while Japan has a similar project for rice. To
remain competitive, Canada should be doing the same with its
major field crops, agricultural animals and commercial tree
species.
"We ought to have aggressive and active programs in those
areas," he says. "Because these other countries are doing it,
and you can see why they're doing it."
Genome mapping research makes it possible to do breeding and
develop new strains of agriculturally important species. To
remain competitive globally new biological knowledge is
crucial.
Smith explains that new strains or whole new crops to help
diversify Canadian farm economies can only be developed here,
for our own climate and requirements.
News
Transgenic Canola in Canada
In Saskatchewan, approximately 30,000 acres have been
contracted by Prairie Pools Inc. to grow Innovator^tm canola,
developed by AgrEvo for tolerance to their glufosinate
ammonium based herbicide, Liberty^tm. Another 10,000 acres are
under cultivation in Alberta.
The contracted growers had a previous history of contracting
with the Pools and demonstrate excellent crop management
abilities. The majority were experienced seed growers. In the
second year of the contract, the farmer is required to grow
cereals or summer fallow on the contracted acreage.
Prairie Pools Inc. estimates that if seed had been available,
up to 750,000 acres of transgenic canola could have been
planted this year.
Monsanto's program for RT73, a glyphosate resistant canola
variety, is small and, while the company had approval for up
to 3,000 acres, it decided to grow on 20 acres in each of the
Prairie Provinces. The contract seed for RT73 will be
delivered directly to Monsanto; the variety will not be
submitted for registration. (see Bulletin Vol. 3 Iss. 4,
April, 1995)
Monsanto does not intend to register RT73 as it has superior
varieties already in the co-op system in anticipation of
release next year.
The Canadian Seed Trade Association Biotechnology Committee
has agreed that no transgenic canola will be exported outside
of North America this year.
Applications for Unconfined Release and Registration
The Canadian government has signed off on four canola
varieties that were approved earlier this year. Two have now
been registered by AgrEvo Canada and Pioneer Hi-Bred
International.
New plants currently pending or close to submission are: corn
varieties from Pioneer Hi-Bred International, ICI and Ciba
Seeds; flax from the University of Saskatchewan and cotton
from Monsanto.
An Industry Canada representative estimates the government
will be reviewing 15 new transgenic varieties per year for the
next two years. This is expected to grow exponentially in the
next five years to 115 or more varieties per year.
More Canola Developments
AgrEvo herbicide approved
Liberty^tm herbicide (glufosinate ammonium) has been
approved by Agriculture Canada for use on a tolerant canola
variety, the first ever commercial clearance for a non-
selective herbicide on a transgenic crop. Innovator^tm, a
transgenic canola variety produced by AgrEvo, was previously
cleared for use in Canada.
The combined use of the new variety and the herbicide, which
AgrEvo calls the Liberty Link^tm system, is being introduced
on a limited scale this season. AgrEvo has offered 80 acre
contracts to some 500 farmers, for a total of 40,000 acres.
The harvested seed will be sold through the Saskatchewan and
Alberta Pools; the Manitoba Pool declined to sell the
transgenic varieties.
For information, contact AgrEvo Canada Inc. at 1-800-667-
5959.
SRC-SeCan Search for Hybrid
A hunt for a new canola hybrid that matures early,
yields high and is resistant to black leg disease has been
joined by Agriculture and Agri-Food Canada's Saskatoon
Research Centre and the SeCan Association. According to AgCan,
work on canola hybrids is heating up because technological
improvements have made it easier to develop new varieties.
Guide to Wild Brassicas
The Centre for Land and Biological Resources Research
has developed definitive guides to the wild germplasm of the
Brassica group.
The five guides, of importance to breeders, biotechnologists
and gene bank managers, cover all aspects of brassica, from
chromosome counts to agronomic traits in wild relatives.
For further information contact Mottie Feldman, Centre for
Land and Biological Resources Research in Ottawa at 613/759-
1847.
Calgene Announces Transgenic High-erucic Canola
Calgene has announced that the company has developed a
transgenic rapeseed oil containing trierucin, which could lead
to a dramatically improved source of erucic acid, which is
used in a wide variety of industrial applications. This was
achieved using an acyltransferase gene from the meadowform
plant. Calgene has also announced that they have cloned and
expressed a plant gene which is key to determining the
structure of vegetable oils and to raising the level of
laurate and myristate in the oil.
Contact: Carolyn Hayworth at 916/753-63
Sask. Chemist Develops "Computer Microscope"
Paul Mezey, director of the Mathematical Chemistry
Research Unit at the University of Saskatchewan, has developed
a molecule fragmentation technique that shows the true shape
of small and large molecules on a computer screen. The simple
technique, that Mezey calls "an additive fuzzy
fragmentation scheme" quickly produces a high-resolution image
for any molecule something previously considered impossible.
The technique is expected to be enormously valuable in
biochemistry, biotechnology, drug design and medicine.
Philom Bios Drops BioMal
Saskatoon company Philom Bios has dropped commercialization
plans for its mycoherbicide BioMal, due to changing market
conditions and high production costs. Designed to control
round-leafed mallow, BioMal was the first mycoherbicide
approved for use in Canada. It had been under development for
10 years.
Development of competing lower cost chemical controls would
have resulted in BioMal being over-priced.
The company intends to use the experience gained in producing
BioMal and in navigating the regulatory process to its
advantage when developing future products. These include a
mycoherbicide for dandelions and other broad-leaved weeds.
Potential bio-fungicides are also being studied.
Goodale Rejects Vet Criticism
Concerns expressed by Dr. David MacDonald, president of
the Canadian Veterinary Medical Association, that federal
budget cutbacks threaten Canada's ability to control animal
diseases and protect food safety have been rejected by
Ralph Goodale, Canada's Agriculture Minister.
MacDonald stated that cutbacks are reducing
veterinarians' involvement in crucial stages of food
production, as well as in the control of diseases such as
brucellosis, tuberculosis and rabies. He suggests microbial
contamination and residues of antibiotics, pesticides and
hormones will be untraceable with the erosion of further
resources for veterinary services. It was also suggested
cutbacks are responsible for government "fast tracking" of the
import of embryos, semen and animals.
Goodale counters that, while reductions are taking
place, Canada's infrastructure will be maintained and denies
fast-tracking is taking place.
New S&T Strategy Proposed
A framework for a federal science and technology strategy has
been proposed by the National Advisory Board on Science and
Technology (NABST) following their assessment of federal
science and technology policy.
The NABST report, called "Healthy, Wealth and Wise", reflects
three main areas: quality of life, wealth and job creation in
the context of sustainable development and advancement of
knowledge.
The report reinforces the importance of S&T in achieving
social and economic objectives, making the case that wealth
generation, advancement of knowledge and quality of life in
Canada are inextricably linked. It suggests ways to improve
overall governance of federal S&T, calls for an accurate
system of S&T data collection and performance measurements,
supports strategic S&T investments and recommends that
sustainable development be prominent in all federal S&T
activities.
Copies of the report are available from the NABST Secretariat,
call 613/990-6260, fax 613/990-2007, Email nabst@ic.gc.ca.
The report is available on the WWW at
http://info.ic.gc.ca/opengov/nabst/nabst.html
New CEPA Regulations Delayed
Regulations under the Canadian Environmental Protection Act
(CEPA) requiring the testing of biotech products not covered
under other legislation have been delayed. The regulations,
which were to be released in April of this year, have been
stalled due to issues that remain unresolved between
Agriculture Canada and Environment Canada.
FlavrSavr^tm Taking a Bruising
Serious packing and shipping problems are the cause of the
bruising and battering of Calgene's famous transgenic
tomatoes. Consequently, Calgene is involved in an overhaul of
its packing methods, setting back the expected timing of the
introduction of the tomato throughout the US market.
Meanwhile, DNA Plant Technology of Oakland boasts that its
Endless Summer variety requires no special handling.
Hormone for Swine Okayed Down Under
Move over bST! Australia's regulatory authorities have
approved pST, a growth hormone for pigs. pST will be injected
into lean pigs to increase muscle accumulation. It is expected
that pST will be commercially available soon. No public
opposition to the product has been reported.
Events
AgBiotech International Conference in Saskatoon
The planning for the Agricultural Biotechnology International
Conference (ABIC '96) continues. The conference will premiere
in Saskatoon from June 11 - 14, 1996.
Organizers are pleased with the enthusiastic response to this
conference from speakers and potential delegates from around
the world.
Some of the special features of the conference include
corporate tours highlighting the network that exists for the
biotech industry between private industry, the University of
Saskatchewan and government agencies. Another exciting event
taking place at the conference is a Chautauqua
evening complete with 11 performing acts, and an array of
cuisine in a Saskatchewan buffet.
For information on registration, exhibition, postering or
sponsoring opportunities, contact; ABIC '96, c/o The
Signature Group, 608 Duchess Street, Saskatoon, Saskatchewan,
Canada, S7K 0R1, Telephone 306/934-1772, fax 306/664-6615, e-
mail: signatur@eagle.wbm.ca
Tissue Culture Conference in Saskatoon
The 4th Canadian Plant Tissue Culture and Genetic Engineering
Conference will be held at the Delta Bessborough Hotel in
Saskatoon, Saskatchewan from June 1-4, 1996. Themes for the
conference are embryogenesis/development and
genes/transformation. Participants are invited to submit
abstracts for the poster session.
For more information contact Dr. Graham Scoles at 306/966-
4944 or fax 306/966-5015; or Dr. Wilf Keller at 306/975-5569
or fax 306/975-4839.
Oats/Barley Genetics Conference
The 5th International Oat Conference and the 7th International
Barley Genetics Symposium will be held concurrently July 30 to
August 6, 1996 at the University of Saskatchewan in Saskatoon.
The combined conferences are the major international forum for
information exchange on all aspects of oat and barley research
and development.
Contact: the Crop Development Centre, University of
Saskatchewan, 51 Campus Drive, Saskatoon, SK S7N 5A8, Canada.
Email: ouellet@abyss.usask.ca
Biotech Colloquium
A Biotechnology Colloquium will be held in Saskatoon,
Saskatchewan October 16-20, 1995 as part of the North American
Plant Protection Organization meeting.
For information call Jane Thibert at 613/952-8000 or fax
613/952-0809.
Science and Tech Education
The 8th Symposium of the International Organization of Science
and Technology Education (IOSTE) will be held in Edmonton,
Alberta from August 17 to 24, 1996. The conference theme is
"Science and Technology Education for Responsible Citizenship
and Economic Development: Evidence, Policy and Practice."
Contact Mr. Raja Panwar, Chair, at 403/427-2984 or fax
403/422-3745 or Email RPanwar@edc.gov.ab.ca
Trends
European Biotech Gathering Momentum
Ernst & Young's Second Annual Report on European Biotechnology
reports that European biotech companies are "gathering
momentum." It states that Europe seems to be warming to
biotech on the political front and that many hurdles to the
development of the industry on that continent are being
dismantled. Germany, it says, may emerge as the "dark horse"
of European biotech in the future, despite its reputation as
being "anti-biotech." More money is also going into biotech,
with the number of companies growing from 386 last year to 485
this year.
Creating Knowledge, Japanese Style
According to a Japanese study (The Knowledge-Creating
Company: How Japanese Companies Create the Dynamics of
Innovation, Nonaka and Takeuchi, Oxford University Press)
the ability to create new knowledge, rather than manufacturing
prowess is a key to corporate advancement. However, the type
of knowledge created is important. According to the Japanese
dynamic, the most valuable knowledge may be the "tacit"
knowledge which can be found in employees hunches, ideals and
skills.
Tacit knowledge is hard to share, especially in big companies,
but Nonaka and Takeuchi have three suggestions.
One: ensure that employees share each other's experiences as
much as possible. This can be done by creating lots of
shifting, flexible teams.
Two: use middle managers who are more in touch with the
grassroots to transmit information upwards.
Three: organize the company to incorporate three types of
structures, a traditional hierarchy to run the day to day
business; flexible, temporary teams to generate new ideas; and
a knowledge base that brings together explicit and tacit
knowledge through everything from databases to the wisdom of
longstanding employees.
Alliances
Monsanto Buys Into Calgene
Monsanto will acquire a 49.9 per cent interest in Calgene Inc.
of Davis, California, the biotech company that produced the
FlavrSavr^tm tomato and other genetically engineered crops.
Calgene was seeking cash, while Monsanto wants to broaden its
interests in biotechnology.
Although reports are that Monsanto paid US$30 million for its
interest in the company, according to Calgene CEO Roger
Salquist, the total deal is worth $200 million. Monsanto will
lend $85 million to Calgene and also transfer its ownership of
a Florida-based produce shipper to the biotech company.
Public-Private Sector Partnerships
The following article is the second installment in a series
based on a presentation to the Plant Science Department,
University of Manitoba in November, 1994 by R.E. Morgan,
Manager of Agricultural Research and Development with the
Saskatchewan Wheat Pool and member of the Board of Directors
of Ag-West Biotech. The first installment outlined the various
forms and advantages of partnerships., primarily those between
business and university/research centres.
Challenges of Partnerships
In addition to the many benefits to be obtained from
forming partnerships, there are also challenges to contend
with.
The greatest challenge is achieving clear communication. In
partnership relationships, most frustrations are due to a lack
of clearly communicated protocols and expectations which have
been spelled out in a written contract identifying measurable
results. Often the importance of such details are overlooked
or set aside in the urgency to "get on with it," leading to
disappointing outcomes.
Some of the challenges that should be identified in advance
include:
* The balance of short and long term desires and needs: the
industry partner should not only fund the project directly or
indirectly, but also contribute a specific amount for longer
term research in the area.
* Issues of ownership, control and protection of technology;
financial expectations and risks for research and
commercialization; and the returns to each party.
* The forms of contribution by each party: dollars and
in-kind contributions and responsibility for regulatory and
intellectual protection.
* Meeting timelines and establishing measures to maintain
focus; milestones need to be set and tracked with minimal
diversion.
* Meeting the needs of the third party, the funder. Balancing
accounting requirements and/or/with just balancing the
books.
* Confidentiality: the need to publish by the university must
be recognized. On the other hand, timing of such publication
should be negotiable in light of competitive advantage. In
addition, the fact that grad students may not be aware of or
see the need of confidentiality requirements must be
addressed. Project cross over and projects of competitors
located in the same lab can be disconcerting; appropriate
action to protect partner's interests must be taken.
* Conflicts of interest, such as personal and competing
projects in the same facility. Competition between research
groups can also be a diversion from the task at hand.
* Research programs associated with such projects can be
hindered by a lack of freedom, lack of information or reduced
long term activity. Too much focus and concern about
industry's needs can lead to deterioration in the educational
role of the department.
* A university administrative bureaucracy with a poor
understanding of business needs/operations.
* Legal bureaucracy or burdensome reporting systems.
* More than two partners in a project can be problematic.
Partners need to make a special effort to communicate and make
agreed upon contributions.
Enhancing partnership success
The key component that can determine the success or
failure of a relationship and the project are the people
involved.
A partnership is contemplated when the potential partners see
some distinct advantages and these outweigh, in total, the
risks or challenges. Anything that can be done to foster the
consummation and the success of the partnership in meeting its
goals must be seriously considered.
Some things that can be done to reduce a number of the more
obvious burdens are:
* The university needs to develop clear guidelines (protocol)
in consultation with industry. These should then be
communicated clearly to university departments, their staff
and industry.
* The university should put in place an effective and
efficient commercial office. The office should be adequately
resourced and have knowledgeable, service-oriented staff who
have both worked in industry and clearly understand the
university system and its needs.
* Regular evaluations will help ensure that the staff follow
appropriate business protocol and develop appropriate protocol
for all commercial arrangements between the university and
business partners.
* The staff of the commercial office should be the primary
contact for all formal relationships being considered and for
the commercialization of university technology.
* They should also participate as required in discussions
between industry representatives and the scientists involved
in the project to ensure an excellent understanding of mutual
requirements.
* Funding agencies which provide financial resources to such
partnerships should ensure (but not dictate) that the
partnership is following a business protocol that demonstrates
a path to the greatest opportunity/potential for success in
the development and commercialization of the technology. All
parties should agree on a common reporting format which
succinctly provides project/budget status, but is not onerous
in preparation. In addition, there should be encouragement to
allocate some resources to longer term research in the area
under development.
* There is a need to use a streamlined process that minimizes
administrative work for the scientist. A straightforward
software package for the projects/budget tracking would be
useful.
A partnership forum
A significant step towards developing an environment
for successful partnerships would be to hold a forum/workshop
where the participants put forward concrete recommendations on
the appropriate business interface and protocol for university
partnerships.
The participants would include appropriate representation from
the university, AgCanada, NRC-PBI, provincial research
institutes, industry and key funding agencies. The presence of
some legal expertise would also be appropriate.
A number of key topics would be included in the information
dissemination portion of the forum/workshop agenda.
Consideration of these topics would also be important during
the workshop format:
* General overview of current university practice and
expectations.
* Protection/ownership/control of intellectual property.
* Performance management.
* Contract basics.
* Conflict of interest and confidentiality.
* Funding partnerships.
* The various partnership definitions.
The next installment of this article will focus on working
in today's reality.
Technology Transfer
Canola Petal Test Commercialized
A testing system used to predict the occurrence of an
important canola disease has been licensed to a Saskatchewan
company, Reed Agricultural Services, by University of
Saskatchewan Technologies Incorporated.
The Canola Petal Test, used to detect Sclerotinia stem rot,
helps farmers to determine the cost effectiveness of using a
control fungicide. Test kits, developed at the University of
Saskatchewan with funding from the Canola Council of Canada
and the Agriculture Development Fund, have been marketed on a
trial basis by the University since 1991.
The transfer of the technology to Reed Agricultural Services
responds to a favorable reaction from canola growers
throughout the prairies, demonstrated by a steady increase in
sales. Reed will manufacture the kits and sell them to
individual growers, agri-service companies and custom chemical
applicators.
Contact: Mark Reed, Reed Agricultural Service, 306/378-2784;
fax 306/378-2811.
Biocontrol for Sclerotinia Around the Corner
Meanwhile, AgCanada and Cominco Fertilizers Ltd. will
commercialize a biocontrol agent for white mold/stem rot
caused by Sclerotinia sclertiorum fungus. First
identified by the Lethbridge Research Centre, the biological
agent is expected to provide control with one application per
season. It is anticipated that the commercial formulation will
be available in three years.
Queens Moves to Enhance Commercialization
PARTEQ Innovations, Queen's University's for-profit technology
transfer agent, is seeking private investments for an
initiative designed to help commercialize the university's
intellectual property. Queen's goal is to obtain $28 million
in investments; the money will go to PARTEQ in return for 30
per cent royalties on any revenue generated from Queens'
intellectual property. The initiative is considered unique in
North America.
Queens undertook some $68 million in research in 1993-94, most
of it funded by the federal government. Its commercialization
wing now represents over 80 projects covered by 30 patents and
60 patents pending. It is hoped that royalties from past and
future research will replace public funds, which are expected
to decrease as the federal government moves to reduce its
deficit.
Finance
New Biotech Loan Fund
An innovative loan fund targeting Western Canada's
biotechnology firms has been announced by Western Economic
Diversification Minister Lloyd Axworthy and the Royal
Bank of Canada's General Manager for Saskatchewan, Gord G.
Tallman.
By providing loans for research and development, product
development and market development, the joint venture is
designed to fill the gap in financing requirements for small
companies in one of the world's fastest growing sectors.
In partnership with Western Economic Diversification (WD), the
Royal Bank will establish a loan fund of up to $30 million to
enable firms to access debt capital for which they were
previously ineligible. In addition to investing $3.75 million,
WD will provide professional services for technology reviews
of projects, support for business in developing proposals,
project monitoring and ongoing management support.
Loans will range from $50,000 to a $500,000 maximum.
Interested companies should contact WD offices in Winnipeg,
Saskatoon, Edmonton or Vancouver to obtain initial application
information and for assistance in developing the necessary
materials and documents. Companies meeting the criteria will
then formally apply to the Royal Bank, where accounts will be
managed by specially trained Knowledge-Based Industry
managers.
For additional information contact Judy Moore, Assistant
Deputy Minister, WD in Saskatoon at 306/975-4373 or Corey
Keith, Senior Account Manager, Knowledge-Based Industries,
Royal Bank in Saskatoon at 306/955-8324.
KPMG Reviews Canada's Biotech Industry
"Overall, 1994 was a moderately progressive year for Canadian
biotechnology," says a 1994/95 update on biotech from the
consulting firm KPMG, "with some new products approved, new
sources of funding and continued support from the government
and the public."
Financing remained a top challenge for the emerging industry,
especially for "the riskier spin-offs emerging from the
university hothouse." However, some new sources of funding
have emerged. Several national banks announced programs to
boost lending to knowledge-based industries.
Despite shifting financial priorities, the federal government
has helped to fill some gaps in the infrastructure for product
development as part of its focus on technology transfer and
product commercialization. One example is the federal
contribution to a biofermentation facility in Saskatoon.
The report also points out that Canada's regulatory regime for
novel products of biotechnology has largely been put into
place, although the number of new products challenges the
resources of the regulatory system.
"It remains to been," the update concludes, "whether
biotechnology can maintain such a steady course under global
industry restructuring and a government resetting its
priorities."
Input on International Strategy Sought
The federal government wants to hear from Canadian biotech
companies about their international priorities for exporting
products and services, attracting investment and acquiring new
technology.
The information will be used to allocate government resources
for servicing the international business interests of Canadian
biotech firms in the health, agriculture, marine and
environmental segments of the industry.
Contact John Jaworski at Industry Canada by Fax at 613/952-
4209 or by Email at jaworsky.john@ic.gc.ca.
Issues
rbST Moratorium Extension Recommended
A further two-year moratorium on the sale of rbST in Canada
has been recommended by the House of Commons health committee.
While Agriculture Minister Ralph Goodale says that he sees no
point in extending the ban, committee member and Reform MP
Grant Hill, a family doctor from southern Alberta, stated that
he is not satisfied that all human health factors have been
addressed.
The growth hormone, which can boost milk production in cattle,
is available for sale in the United States, but has been
withheld in Canada while authorities assess the issues,
including consumer reaction in the US.
In the US, consumers "appear totally unconcerned about
synthetic bovine somatotropin (bST)," according to a report in
Country Guide magazine. Their evidence is that milk sales have
continued to increase since the introduction of rbST south of
the boarder.
Meanwhile, the Alberta Veterinary Medical Association (AVMA)
has endorsed rbST, saying that it is not a threat to either
animal or human safety. However, the AVMA advises that
although the use of rbST improves milk production and
efficiency, it does not replace the overall requirements for
quality herd management.
American Religious Leaders Oppose Gene Patents
The Southern Baptist Conference in Atlanta has adopted a
resolution calling for "an immediate moratorium on the
patenting of animal and human tissues and genetic sequences
until a full and complete discussion has concurred." The
resolution adds to a growing religious opposition to gene
patenting.
Previously, some 180 leaders of mainstream Christian, Jewish,
Muslim, Hindu and Buddhist religions petitioned the US Patent
and Trademark office to reverse its policy of granting patents
for human and animal genes. While the leaders say they do not
oppose biotechnology, as such, for religious reasons, they
state that "humans and animals are creations of God, not
humans and as such should not be patented as inventions."
The group suggested that biotech companies could use some
other mechanism, such as contract law, to protect intellectual
property without claiming ownership through patents. However,
the biotech industry counters that patents are essential in
protecting the major investments involved in developing
biotechnologies.
Bt Genes and Organic Farmers
Organic farmers are challenging the introduction of potatoes
and other crops that have been engineered to contain insect
toxin genes from Bacillus thuringiensis. They claim
that the widespread adoption of Bt crops will accelerate
resistance to Bt insecticides as a result of continuous
exposure to the toxins as insects feed on engineered crops.
This would reduce the efficacy of Bt as a pesticide acceptable
to organic farmers. Further, the loss of Bt as an insecticide
would result in a return to chemical insecticides for insect
control.
Labelling Not Always Necessary, Say EU Experts
A group of European ethics experts believes that there is no
need for systematic labelling of transgenic foods. The
European Commission's advisory group says that only foods
substantially altered by genetic engineering should be
labelled to alert consumers. Substantial changes would be
those that relate to composition, nutritional value or
intended use of the food.
The group also says that, when used, labels should specify the
nature of the change and the process employed and be
informative, clear, easily understandable and honest. The
group also feels information can be made available through
other sources than labels, such as hotlines and databases,
enabling consumers to obtain additional information if they
want it.
The European Union has been unable to reach an agreement on
the labelling of novel foods. Recently, a compromise proposal
has been submitted which follows the recommendation of the
advisory group.
Labelling of transgenic foods is not required in Canada, the
United States or Japan.
Attitudes
Public Determines if Agbiotech Products Will Fly
What is a viable product?
According to Peter Desai, Director of Research and
Development for Dow Elanco Canada, a viable product is one
that the public will buy. The best science, reams of test data
and company pronouncements mean nothing if the customer
refuses to put cash on the counter.
Desai's comments were part of his summary and closing
address at the Value Added Cereals Through
Biotechnology conference held in Saskatoon from June 10
to 13.
Desai warned that scientific strength will not
guarantee commercial success, it is merely the entry fee to
get in the game. Success depends on public acceptance and
confidence, which aren't always responsive to scientific
arguments.
He gave the example of a video conference held in May, in
conjunction with the Biotechnology Industry Organization's
annual conference. The panel was flooded with calls from
individuals and groups like professional chefs who demanded,
"Who gave you the right to play God?" and other similar
questions. While Desai says there were some positive
calls, there were many based on ethical and emotional issues,
which are difficult to answer with a purely scientific
approach. Nevertheless, if they are questions that the public
wants addressed, they must be dealt with.
Another problem is that science is complicated.
"People don't understand science and are reluctant to learn,"
Desai says.
He suggests education can start at home. People in the
agbiotech industry should find out what family and friends
think of biotech, then explain the facts, without getting
defensive and let them make up their minds.
"We need to educate the group that we interact with every
day."
Even when the public is receptive, industry can hamstring its
own education efforts through language. Words like "genetic
engineering", gene manipulation", or "synthetic genes" may all
have precise meanings to scientists, but they evoke uneasiness
or even hostility in the public. Scientists need to think
about what words they use to explain their science.
"Manipulation" for example, can become "modification", a more
neutral word that still conveys the appropriate meaning.
Industry proponents also have to put themselves in the
customer's shoes. What's in it for the consumer? A better
cooking oil, perhaps? These benefits should be put in every
day terms with which people can identify.
Desai urged conference participants to become active in
educating the public about the industry if products of
agbiotechnology are to enjoy commercial success.
"If you do what you always did, you'll get what you've always
got. In today's world, we cannot afford to do this."
Value Added Cereals Through Biotechnology was organized
by the NRC's Plant Biotechnology Institute, Agriculture and
Agri-Food Canada, the University of Saskatchewan and Ag-West
Biotech Inc.
Contact: Rosemarie Gallays, Plant Biotechnology Institute,
National Research Council. Ph.: 306/975-5571, Fax: 306/975-
4839. PBI is also on the World Wide Web at
http://ad94old.pbi.nrc.ca/pbiintro.html
Canadian Consumers Wary of bST Milk
Winnipeg public opinion pollster Angus Reid says Canadian
consumers are suspicious of rbST. The company's recent poll
indicates that 75 per cent of Canadians are concerned about
the possible use of bST in Canada; in fact, almost half of
those surveyed said they would pay more for non-rbST milk,
with another quarter indicating that they might pay more. The
fact that people will back up their concern with money is
usually a strong indication of depth of concern.
Ruth Jackson, President of the Consumers Association of
Canada, indicated that she is suspicious of the Angus Reid
poll, which she claims is at odds with previous surveys.
However, Curtis Johnson of the Angus Reid Group says
that the survey is consistent with previous research
done in Ontario. "Their research was more detailed than ours.
It included information on the rationale for people's
concern."
Johnson says that American polls show different results
than Canadian surveys, perhaps because American surveys tend
to measure consumer reactions to milk in general, while the
Canadian polls judged reaction to rBST milk and non-rbST milk
separately.
"US and Canadian consumers are different," says
Johnson. "Canadians tend to be slightly more
knowledgeable and concerned about food issues." He also says
that other research shows that Canadians are less price
sensitive than Americans, which could explain why Canadians
would be willing to pay more for rbST-free milk.
To illustrate the differences in consumer attitudes about
prices, Johnson cites an example from the retail
industry. "Major Canadian retail companies commonly use sale
items to attract customers into their stores. Once in the
store, customers buy other items at regular prices. This
strategy doesn't work in the US. The American consumer just
comes for the sale item and leaves."
Johnson says his company is not trying to generate
concern, but believes the industry should know what consumers
are thinking. He says the adverse reaction to rbST may have
occurred because proponents "are not doing a good job of
communicating what bST is. There are conflicting stories about
safety. When consumers hear that there are traces of bST in
milk, it causes concern," even though naturally occurring bST
has always been present in cows' milk.
Reid has also researched farmer opinions on rbST. "Dairy
farmers are also concerned about the impact that rbST may
have," says Johnson. "This may be partly due to
possible consumer reaction and partly because of their
concerns about animal health." Johnson points out that polling
indicates that farmer concern about rbST does not translate to
plant transgenics. "On the seed side, farmers apparently feel
no concern."
A spokesman for the National Dairy Council of Canada has
stated that consumer attitudes about rbST "pose a huge threat
to our industry." The Canadian dairy processing industry
remains opposed to the use of rbST in Canada.
CDA Committee Favours Biotech
A position paper of the Biotechnology Committee of the
Canadian Dietetic Association has endorsed the value of
biotechnology in maintaining an abundant and sustainable food
supply. However, the Committee reports it has not yet been
able to achieve consensus of its position with all provincial
associations.
In summary, the paper states:
"Biotechnology allows scientists to improve foods, create new
food products and provide better tools to ensure food safety.
It can assist in achieving the goal of an abundant, safe and
nutritious food supply for a growing population. These
technologies can lead to a greater variety of foods with
improved taste, nutrition and cooking quality. There are valid
concerns about the widespread use of biotechnology which
remain to be addressed by health, scientific and consumer
constituencies. Dietitians need to be informed about
biotechnology in food production and processing. They need to
be aware of potential benefits and risks. Dietitians are
uniquely positioned to inform the public about food safety and
food products of biotechnology. Dietitians can discuss this
information in understandable language and with sensitivity to
public values. Dietitians should participate in the
development of food-related policies at local, provincial and
federal levels."
Legal Notes
Who's Suing Whom?
American legislators recently beefed up that country's Plant
Variety Protection Act, giving developers of new plant
varieties stronger control of genetic property. The American
action, along with recent legislation in Europe and agreements
between Japan and the US and China and the US on patent
issues, indicate a trend toward strengthened proprietary
rights.
Without strong proprietary protection, the substantial
investments in research and development by agbiotech companies
needed to produce new crop varieties can be undermined. For
example, Pioneer Hi-Bred spent some $115 million on research
and development last year.
That's why Pioneer is acting aggressively to protect the
products it develops through its research programs. The seed
company uses DNA fingerprints, or molecular marking, to
monitor its products.
Patent infringement can be a high stakes game. Pioneer was
awarded $47 million dollar in damages last year from Holden's
Foundation Seeds, when Pioneer's genetic material was found in
Holden's product. This year, Pioneer is suing Crow's Hybrid
Corn Co. for misappropriation of trade secrets and violation
of the Plant Variety Protection Act.
Meanwhile, a patent battle is underway between Calgene and
Enzo Biochem. The companies are in court over the ownership of
the antisense technology behind the FlavrSavr tomato. Enzo
alleges that Calgene's claim of an earlier patent for the
plant is invalid due to fraudulent research by the inventor. A
loss of the case by Calgene could mean that the company would
have to pay a royalty to Enzo.
Giant drug and chemical company Monsanto (which recently
acquired half of Calgene) is also fighting over tomatoes, with
DNA Plant Technology. Monsanto alleges that DNAP violated two
of its patents that control the ripening of tomatoes. DNAP has
launched a counter-suit.
Resources
BioResearch Ireland
BioResearch Ireland has released its annual report for 1994.
BioResearch, established in 1988 to commercialize Irish
research in biotechnology, now employs 230 staff and performs
R&D services on behalf of 238 industrial clients.
Copies from Phil O'Leary, BioResearch Ireland, Forbairt,
Glasnevin, Dublin 9, Ireland. Tel. 353 1 8370177 or fax: 353 1
8370176.
Canola Info Service for Sask
A Canola Information Service for consumers has been launched
by the Saskatchewan Canola Development Commission. The service
helps callers understand how to buy, store and incorporate
canola oil and canola oil products to maximize nutrition,
flavour and safety at home or in commercial kitchens. The
service is free, with educational/nutritional information
available to consumers, health professionals, food service
personnel and media.
Call the Canola Information Service at 306/664-7117
Export Strategies
Canada's Export Strategies The International Trade Business
Plan, 1995/96 (Biotechnologies), is a summary of Canada's
international trade plans relevant to biotech and includes
planned activities.
Call 1-800/267-8376 for copies.
Info Systems for Agbiotech
Information Systems for Biotechnology, an electronic resource
in agbiotech, contains the latest news in R&D, product
commercialization and regulatory information. Search output
and documents can be downloaded to the user's computer.
Access using gopher, ftp, telnet ir WWW to connect to
ftp.nbiap.vt.edu. Contact: Doug King at 703/231-3747; Email:
nbiap@vt.edu
Electronic TechTransfer Service
Trans Forum contains information from Canadian universities
and institutes related to tech transfer and industry liaison.
Includes an "opportunities match" mailing list.
Connect at http://schoolnet.carleton.ca/Trans-
Forum/english.html
People Watch
Canadian Dietetic Association
Lynda Corby has been elected president of the Canadian
Dietetic Association for 1995-96. Corby, the co-author
of two successful books on nutrition, fitness and self-esteem
for children and was recently involved in a review of the
delivery of nutritional services in her native Manitoba.
Canola Council of Canada
Keith Downey has received the James McAnsh Award, the
highest award available from the Canola Council of Canada. The
award recognizes Downey's contributions to the
development of 18 varieties of canola during his 40 year
career with Agriculture and Agri-Food Canada. Downey is
research scientist emeritus at the Saskatoon Research Centre.
Edna Downey was also honored for her work to promote
the use of canola oil in cooking and for her long term support
to her husband research efforts.
Ken Sarsons, who influenced the Saskatchewan Wheat Pool
to invest in crushing and marketing rapeseed as an alternative
to wheat and barley, was awarded a lifetime membership in the
Canola Council Sarsons was, variously, chief executive
officer of CSP Foods, Alberta Food Products and XCAN Grain.
Canodev
Rod MacInnes has been hired as Manager of Research for
Canodev, a wholly-owned subsidiary of the Saskatchewan Canola
Development Commission. Among other accomplishments,
MacInnes was Manager of Market Development for Esso
Agbiologicals in Saskatoon.
Cyanamid Canada
Dwight E. More has joined Cyanamid Canada's Winnipeg
office as Director of Operations for Western Canada.
More resigned as President of the Canola Council of
Canada at the end of July.
Canadian Seed Trade Assn.
Bob Ingratta, Director of Government and Regulatory
Affairs for Monsanto has completed his term as chairman of the
CSTA Biotechnology Committee. He continues to take an active
role in the International Trade of Transgenic Canola
committee, which is comprised of industry and government
representatives.
Brent Kennedy, Manager of Research and Development for
AgrEvo, assumes chairmanship of the CSTA Biotechnology
Committee. The committee's primary mandate is to facilitate
the development of regulatory standards for Canada. Kennedy
was previously vice-chairman.
Ian Grant, Head of Canola Research with Pioneer Hi-
Bred International, is the committee's new vice chairman.
Barb Fowler, Manager of Regulatory Affairs for Plant
Genetic Systems, takes over Grant's duties as
Secretary.
Bill Parks, President of Pioneer Hi-Bred's Canadian
operations, was assumed office as CTSA President on July 11,
1995, taking the helm from Lloyd Dyck, President of
Rhett Young Seeds.
Hoechst
Horst Waesche, former president of Hoechst Japan, has
joined the Board of Directors of Hoechst. Waesche will
be responsible for AgrEvo, Hoechst Veterinary, the Asian
region, as well as the company's information and communication
departments.
Mallinckrodt Veterinary
Ronald Gauthier, formerly general manager of Syntex
Animal Health's Canadian operations, is now general manager of
Mallinckrodt Veterinary for Canada. Gauthier is
responsible for ethical and OTC business.
Pioneer Hi-Bred
Dr. Anthony J. Cavalieri has been elected as vice-
president and director of trait and technology development
with Pioneer Hi-Bred International, Inc. Cavalieri will
oversee the research support and biotechnology groups.
VIDO
Dr. Peter Rempel of Regina, Saskatchewan has been
appointed to replace Al Hingston as the Government of
Saskatchewan representative on the Board of the Veterinary
Infectious Diseases Organization (VIDO). Ian Thompson
of Carnduff, Saskatchewan will replace George Schoepp
as the Beef Cattle representative.
Copyright 1995 Agbiotech Bulletins
|