ISBN: 0-896-03717-7
Code Number:OC00048
Vaccine has without question been among our most powerful tools for preventing
diseases, disability and death, and controlling health care costs. Recent advances in gene
cloning and expression, peptide synthesis and other technologies have created opportunities
for developing bioengineered vaccines that promise a substantial return on research and
development costs. The implementation and improvement of combination vaccines is an
important tool to accelerate the global immunization of infants against multidiseases. It will
reduce the number of injections that individuals must receive in order to develop immunity
against several diseases, in the hope that fewer immunization will lead to increase
vaccination rates saving and improving lives in several countries, especially in developing
countries.
The book Combination Vaccines: Development, Clinical Research and Approval
is a comprehensive and concise reference on several aspects of multidisease and multivalent
combination vaccines. It describes a large number of combination vaccines in current uses
and under development and gives data from controlled studies on these vaccines revealing
the effects of this combination in relation to immunogenicity and safety in comparison with
the individual vaccines. The list of available combination vaccines and the schedules for
routine pediatric immunization shows the complexity of the technical task involved in their
development.
Data on the efficacy of combination vaccine for most widely used vaccines is highlighted
in terms of its component and the type of immune response associated with protection. A
summary of the general properties of the vaccines and the target potential populations are
also given.
The book is also an update on the latest vaccines submitted for licensure such as a
multivalent vaccine against rotavirus diarrhea, which kills 6-800,000 children each year and
the new vaccines developed against Streptococus pneumoniae, responsible for
1,2-million childhood death from pneumonia.
Moreover, the conventional sequence for evaluation and licensure of combination
vaccines are described such as formulations, stability, and compatibility of antigens and
preclinical testing. The book is a guideline to all those who are interested in testing vaccine
combinations.
Cláudio Tadeu Daniel-Ribeiro