Indian Journal of Pharmacology Medknow Publications on behalf of Indian Pharmacological Society ISSN: 0253-7613 EISSN: 1998-3751 Vol. 38, Num. 6, 2006, pp. 438-438

Indian Journal of Pharmacology, Vol. 38, No. 6, November-December, 2006, pp. 438

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Das SK, Vasudevan DM

Department of Biochemistry, Amrita Institute of Medical Sciences, Elamakkara P.O., Cochin-682 026
Correspondence Address:Department of Biochemistry, Amrita Institute of Medical Sciences, Elamakkara P.O., Cochin-682 026 Email: subirkumardas@aims.amrita.edu

Code Number: ph06127

Related Article: ph06126

We sincerely appreciate the interest shown by the readers in our article entitled "Drugs and non-alcoholic steatohepatitis" (Indian J Pharmacol 2006;38:238-42). Non-alcoholic steatohepatitis (NASH) has been associated with obesity, diabetes, hypertriglyceridemia and hypertension. In addition, NASH has also been associated with hyperlipoproteinemia, jejunal bypass surgery, parenteral nutrition and drugs. In this article, we highlighted lists of drugs that are commonly used for the treatment of obesity, diabetes, hypertriglyceridemia and hypertension, irrespective of geographical barrier, and associated with hepatoxicity. We also tried to discuss briefly the mechanism of action of these drugs. A number of pharmacologic agents have been shown to be promising in the treatment of NASH, but they need to be studied further. In fact, a trial, utilizing troglitazone, had shown encouraging results, but because of reports of rare but serious hepatotoxicity, the drug has now been withdrawn from the market.[1] Therefore, awareness about these hazardous drugs is very important.

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Copyright 2006 - Indian Journal of Pharmacology