|
Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613 EISSN: 1998-3751
Vol. 39, Num. 6, 2007, pp. 303-306
|
Indian Journal of Pharmacology, Vol. 39, No. 6, November-December, 2007, pp. 303-306
Workshop Report
The basic concepts of scientific research and communication: (A Report on Preconference Workshop Held in Conjunction with the 40th Annual Conference of the Indian Pharmacological Society-2007)
Balakumar Pitchai, Murthy Sreekant, Jagadeesh Gowraganahalli
Department of Pharmacology, ISF College of Pharmacy, Moga - 142 001, Punjab
Correspondence
Address:Department
of
Pharmacology,
ISF
College
of
Pharmacy,
Moga
-
142
001,
Punjab,
pbala2006@gmail.com
Code
Number:
ph07078
The 40 th annual conference of the Indian Pharmacological Society (IPS) was held at the National Institute of Pharmaceutical Education and Research (NIPER), Mohali, Punjab, from November 01 to 03, 2007. The conference focused on ′Changing Trends in Drug Discovery and Development′ and was preceded by a workshop on ′The Basic Concepts of Scientific Research and Communication′. The preconference workshop was organized by Dr. G. Jagadeesh from US Food and Drug Administration on October 31, 2007. Below we present the proceedings of the workshop for the readers who could not attend it.
Postgraduate
education
and
pre-/postdoctoral
fellowship
are
important
steps
for
becoming
a
scientist.
Research
is
the
original
and
intellectual
investigation
undertaken
to
discover,
interpret,
revise
the
knowledge
and
improve
the
understandings
of
any
facet
of
science
or
a
major
subject
of
its
specialization.
It
includes
the
generation
of
many
ideas
that
lead
to
new
or
substantially
improved
insight
with
the
relevance
to
the
needs
of
the
society.
In
essence,
the
goal
of
the
research
process
is
to
produce
new
knowledge.
Most
postgraduate
(PG)
students
are
not
exposed
to
the
process
of
developing
a
research
protocol
or
study
design-the
very
first
step
in
scientific
research-before
they
actually
delve
into
research.
Additionally,
they
are
not
trained
to
communicate
(oral,
poster
or
full
paper)
the
laboratory
findings
in
an
appropriate
format.
A
number
of
universities
around
the
globe
have
introduced
a
mandatory
course,
e.g.,
principles
of
research
methods,
principles
of
scientific
research,
experimental
study
designs,
grant
writing,
etc.,
coupled
with
teaching
communication
skills
and
ethics
(at
the
PG
level)
into
the
curriculum.
There
is
a
growing
awareness
in
the
scientific
community
regarding
the
benefits
in
imparting
these
skills
before
a
student
begins
his/her
first
day
of
research.
Broad-based
training
in
the
scientific
methods
of
research
and
communication
are
essential
before
an
individual
can
pursue
a
scientific
and/or
academic
career.
An
experiment
is
a
well-conceived
plan
for
data
collection,
data
analysis
and
data
interpretation.
Consequently,
PG
students
should
learn
a
step-by-step
developmental
process
to
write
an
effective
research
protocol
that
is
not
overly
ambitious
or
difficult
to
complete
in
the
given
time
frame
(e.g.,
1-2
years
for
PG
students
and
approximately
3
years
for
Ph.Ds.).
The
research
should
have
the
potential
for
success,
advancing
the
knowledge
in
the
field
of
interest
and
strengthening
their
future
career
prospects.
Keeping
this
in
mind,
the
primary
aim
of
this
workshop
was
to
provide
the
understanding
of
basic
research
concepts,
how
to
systematically
develop
a
research
protocol/proposal,
how
to
appreciate
the
importance
of
conducting
a
research,
researching
using
good
laboratory
practices,
seek
funding
for
research
and
communicating
research
goals,
objectives
and
the
research′s potential societal benefits.
The
workshop
commenced
with
a
welcome
address
by
Dr.
P.
Ramarao,
the
organizing
secretary
of
the
40 th annual
conference
of
the
Society
and
Director
of
NIPER,
Mohali,
Punjab.
He
stressed
the
importance
of
such
workshops
in
building
the
career
of
young
scientists.
Later,
the
convener
of
the
workshop,
Dr.
G.
Jagadeesh,
outlined
the
learning
objectives
of
the
workshop,
explaining
that
the
first
part
of
the
workshop
will
comprise
7
lectures
discussing ′building basic steps into research′; the second part will comprise 8 lectures devoted to the basic elements and logistics of ′writing a scientific article′ for publication. The final aspect of the workshop, after all presentations, was the ′panel discussion′.
There
were
six
sessions
in
all
with
15
presentations
made
by
distinguished
speakers
from
India
and
abroad.
All
the
sessions
were
completed
on
time,
including
time
for
discussions
after
each
presentation.
Approximately
100
participants
attended
the
preconference
workshop.
All
delegates
received
a
copy
of
the
PowerPoint
slide
presentations
along
with
a
short
biographical
description
of
the
speakers.
In
addition,
supporting
materials
for
some
of
the
presentations
were
also
made
available
to
the
participants.
The
first
lecture
of
the
workshop
was
conducted
by
Dr.
Sreekant
Murthy
from
Drexel
University
College
of
Medicine,
Philadelphia,
USA.
He
described
and
correlated
the
five
building
blocks
of
research:
ideas,
objectives,
rationale,
hypothesis
and
significance.
In
addition,
Dr.
Murthy
elegantly
described
the
potential
approaches
toward
becoming
a
research
scientist.
Following
this,
Dr.
G.
Jagadeesh
from
the
Center
for
Drug
Evaluation
and
Research,
US
Food
and
Drug
Administration,
Maryland,
USA,
spoke
on
writing
a
research
protocol/proposal-a
roadmap
for
research.
His
presentation
dealt
with
defining
the
objectives,
methodology
and
design
of
a
study
protocol
successfully.
Dr.
Murthy
and
Dr.
Jagadeesh
emphasized
on
a
responsible
conduct
of
the
research,
experiments
and
collection
of
data,
writing
and
publishing
scientific
papers.
From
the
lectures
of
Dr.
Murthy
and
Dr.
Jagadeesh,
the
participants
had
the
opportunity
to
learn
that
the
first
critical
step
in
scientific
research
is
to
identify
the
research
problem
(research
question).
In
order
to
formulate
a
problem
for
study,
a
specific
research
question
(a
good
or
novel
scientific
idea)
is
essential
before
a
study
can
be
designed.
The
research
question
or
the
idea
needs
to
be
carefully
evaluated
and
nurtured
because
it
drives
the
study,
and
thus,
the
research
question
and
the
study
design
are
the
two
most
important
components
of
a
study
protocol.
At
the
outset,
the
specific
research
question
or
researchable
problem
should
be
clearly
defined.
Following
are
the
base
for
the
formulation
of
the
research
question:
(a)
critical
or
intelligent
observations
made
on
an
ongoing
study
in
the
investigator′s laboratory (b) identification of a gap in research based on a literature review (on a topic or idea of study in which a researcher is interested) and adding additional important variables to define objectives and research outcome. The formulated research question should be developed into hypothesis(es). The hypothesis is tested using different designs and variables. The statistics should test the relationship specified in the hypothesis. The study design follows a set plan with primary and secondary objectives. An important point to remember here is that when the project is evaluated, the results will be compared to the objectives defined at the outset. If the objectives have not been spelled out clearly, the project cannot be evaluated. These should be described in the introduction followed by a literature review. A clearly written purpose of the study should be included with the protocol. A statement regarding the specific goal(s) of the study should be comprehended from the problem. Furthermore, how to write ′background and significance′ and ′rationale′ for the study were discussed.
One
of
the
major
aspects
of
scientific
research
is
the
statistical
analysis
of
the
obtained
data.
On
behalf
of
Dr.
R.M.
Pandey
from
the
All
India
Institute
of
Medical
Sciences,
New
Delhi,
Dr.
Kalaivani
(of
the
same
institute)
discussed
the
types
of
experimental
designs
and
statistical
methods
of
analysis
in
both
clinical
and
experimental
pharmacology
studies.
She
explained
the
ways
and
methods
of
expressing
data,
testing
the
significance
of
data
between
the
groups
and
the
application
of
various
statistical
procedures
based
on
the
type
of
data
collected
such
as
parametric
or
non-parametric
with
various post hoc statistical
analyses.
On
behalf
of
Dr.
S.K.
Kulkarni,
Faculty
of
Pharmaceutical
Sciences,
Panjab
University,
Chandigarh,
Dr.
Asish
Dhar
(of
the
same
department)
presented ′Thesis: From protocol to final submission′. Dr. Dhar presented an interesting topic for PGs and Ph.Ds.: how to write and organize a thesis. He emphasized that completing any research project requires meticulous planning, execution, compilation and interpretation of data either in the form of a research paper or a dissertation/thesis.
Numerous
universities/colleges
lack
adequate
laboratory
facilities
and
have
a
less
than
ideal
atmosphere
to
carry
out
experimental
studies.
A
number
of
researchers
and
teachers
working
here
face
tough
challenges
in
completing
their
work
as
they
struggle
to
secure
funds
for
their
research
projects.
The
major
reasons
may
be
a
lack
of
an
awareness
of
the
funding
opportunities
and
techniques
needed
in
preparing
research
proposals.
Dr.
C.
Adithan
from
Jawaharlal
Institute
of
Postgraduate
Medical
Education
and
Research
(JIPMER),
Puducherry,
spoke
on
how
and
where
to
find
financial
support
within
and
outside
India.
Dr.
Adithan
presented
the
details
for
seeking
financial
support
from
various
funding
agencies
such
as
ICMR,
DBT,
DST,
CSIR,
AICTE,
UGC,
etc.
Furthermore,
Dr.
Adithan
carefully
outlined
the
guidelines
for
international
collaboration
for
research
in
biomedical
sciences
in
India.
He
informed
that
the
states
of
Delhi
and
Punjab
have
secured
the
largest
number
of
funds
in
the
recent
years
from
various
grants-in-aid
agencies.
He
recommended
that
a
well-written
proposal
in
the
priority
area
of
the
concerned
research
organization
or
funding
agency
will
have
a
better
chance
of
being
funded
even
if
the
investigator
is
a
beginner.
In
this
paper′s author′s opinion, the IPS should organize workshops periodically training teachers and researchers on how to write and submit grant proposals to various national agencies. This would go a long way in increasing the research productivity and visibility of Indian pharmacologists in the global arena.
How
good
are
we?
We
cannot
simply
be
good
to
ourselves;
we
should
universally
demonstrate
our
excellence.
This
goodness
applies
to
our
laboratory
practices
in
preclinical
studies.
Dr.
Y.K.
Gupta
from
the
All
India
Institute
of
Medical
Sciences,
New
Delhi,
spoke
on ′Good laboratory practice (GLP)′. He stressed on the need for enforcing GLP not only for the pharmaceutical industry but also for the research laboratory and academic institutions so that the preclinical data is ′reliable and reproducible′. GLP is a quality system focused on organizational process and the conditions, under which preclinical studies are planned, performed, monitored, archived and reported. Dr. Gupta reminded everyone that until GLP is enforced as the official regulation in India, it should be in the best interest of all concerned researchers and research managers to self-impose the GLP guidelines in order to make our data globally acceptable.
The
value
of
research
outcome
could
be
assessed
by
its
publication
in
a
journal
of
repute.
However,
most
of
researchers
are
naive
regarding
publication
ethics.
Dr.
Raveendran
from
JIPMER,
Puducherry,
spoke
on
the
essential
topic
of
publication
ethics.
Dr.
Raveendran
indicated
that
a
good
researcher
should
know
that
it
is
unethical
to
submit
the
same
article
to
multiple
journals
at
the
same
time,
not
considering
the
guest
authorship,
falsify
or
fabricate
research
results,
neglect
toward
undeclared
conflicts
of
interest,
publish
the
same
results
in
multiple
journals,
plagiarize
(stealing
others
ideas
and
contents
of
a
paper)
and
use
inappropriate
acknowledgements.
Additionally,
he
discussed
how
editors
as
well
as
peer
reviewers
should
ethically
conduct
themselves
when
reviewing
a
manuscript.
Dr.
Perdeep
Kumar
of
Elsevier
Publishers,
South
Asia
Division,
New
Delhi,
enlightened
the
audience
regarding
the
Journal
Impact
Factor.
Dr.
Kumar
said
that
the
impact
factor
is
a
measure
of
the
citations
to
science
and
social
science
journals.
It
is
frequently
used
as
a
proxy
for
the
importance
of
a
journal
in
its
field.
The
impact
factor
for
a
journal
is
calculated
based
on
a
three-year
period
and
can
be
viewed
as
an
approximation
of
the
average
number
of
times
the
published
papers
are
cited
in
the
two
calendar
years
following
publication.
A
successful
bench
work
should
be
translated
into
a
publishable
scientific
paper.
The
paper
informs
regarding
the
project
handled
right
from
the
thought
process
to
the
answer
found
for
the
key
question.
Thus,
writing
a
research
paper
is
no
easier
than
the
research
itself.
The
main
thrust
of
scientific
research
is
on
publication.
It
is
the
stepping-stone
for
future
success
in
the
scientific
career
of
a
researcher.
Writing
is
an
organic
process
of
planning,
researching
and
drafting,
revising
and
editing.
Sound
research,
critical
thinking
and
creative
writing
when
combined,
enables
a
researcher
to
remain
competitive,
opening
up
further
opportunities
for
collaboration,
professional
growth
and
success.
Learning
how
to
conduct
a
research
fruitfully
and
receiving
the
results
by
publishing
in
a
reputed
journal
is
an
arduous
task,
not
only
for
a
PG
or
a
prePh.D.
student
but
also
for
junior
faculty
members.
This
was
stressed
by
Dr.
Y.K.
Gupta
who
spoke
on
behalf
of
Dr.
K.
Satyanarayana
from
the
Indian
Council
of
Medical
Research,
New
Delhi,
who
was
unable
to
attend
the
session.
While
discussing
how
to
write
a
research
paper,
he
suggested
that
participants
prepare
their
manuscripts
following
the
IMRaD
(Introduction,
Methods,
Results
and
Discussion)
principle,
with
every
section
supporting
the
main
message.
He
described
the
details
of
selecting
an
appropriate
title,
helpful
abstract,
key
words,
running
title,
questionnaire
for
writing
an
effective
introduction,
methods
to
allow
replication
of
the
work
performed,
clear
and
succinct
presentation
of
data
with
statistical
analysis
that
answers
the
research
question,
and
finally,
a
skillful
interpretation
of
data
in
the
manuscript.
Dr.
Rakesh
Aggarwal
from
Sanjay
Gandhi
Postgraduate
Institute
of
Medical
Sciences,
Lucknow,
delivered
two
sequential
lectures, Presenting Results and Persuasive Discussion .
He
lucidly
explained
the
treatment
of
data
before
writing,
the
components
of
the
results,
how
to
format
and
appropriately
insert
tables,
figures
and
text
in
a
meaningful
manner
and
how
to
begin
writing
these
subsections
in
an
organized
way.
During Persuasive Discussion ,
he
said
that
the
discussion
section
is
the
crux
of
the
research
paper
and
it
should
be
decisively
written
on
the
basis
of
results
obtained
in
a
study.
He
explained
a
simple
basis
for
constructing
discussion
and
stressed
that
the
researcher
address
strengths
and
limitations,
the
need
to
compare
and
contrast,
the
potential
significance
of
the
findings
and
a
proposal
for
further
research
that
should
be
undertaken.
He
provided
an
example
of
writing
a
discussion
using
his
own
publication.
Dr.
Amitabh
Prakash
from
Wolters
Kluwer
Health/Adis,
Auckland,
New
Zealand,
pleasingly
suggested
the
usage
of
language
and
style
in
the
scientific
writing
of
a
paper
for
publication.
Dr.
Prakash
said
that
the
language
used
in
scientific
writing
should
have
accuracy,
brevity
and
clarity
and
the
aim
of
a
manuscript
should
be
clear,
unambiguous
and
easy
to
read.
The
last
thing
to
be
written
in
a
manuscript
is
an
effective,
eye-catching ′Title′ and ′Abstract′. The purpose of a title, Dr. Aggarwal noted, is to draw the attention of a prospective reader to the paper and to induce them to read the entire paper or at least the abstract. The title should describe the research succinctly, tells the reader what to expect in the paper, while avoiding overstated and long titles. He provided several examples to illustrate his points. With regard to writing an abstract, he noted two types, unstructured and structured .
The
structured
abstract
should
be
in
the
brief
pattern
of ′IMRaD′. The latter has become the standard for most journals. He illustrated both types, including examples. Dr. Gitanjali Batmanabane from JIPMER, Puducherry, explained the manner of writing references in a manuscript and further emphasized the points made by Dr. A. Prakash. Dr. Batmanabane described in detail two major referencing systems such as Vancouver and Harvard for citing references in a manuscript. She also noted the use of bibliographical software programs, such as Reference Manager, Endnote, Procite, etc., in writing the manuscript.
Dr.
Amitabh
Prakash
delivered
the
final
presentation
regarding
the
peer
review
process
of
a
manuscript.
Dr.
Prakash
illustrated
the
various
steps
involved
in
the
peer
review
process.
He
pointed
out
the
drawbacks
of
the
peer
review
process
and
post-publication
peer
review.
From
his
own
experiences
as
an
editor
for
various
journals,
Dr.
Prakash
discussed
the
role
of
an
editor
after
a
peer
review
is
complete
and
what
referees
specifically
do
in
reviewing
a
manuscript.
After
all
15
presentations,
panel
discussion
began
that
included
all
speakers
and
a
few
invited
senior
professors.
It
was
moderated
by
Dr.
G.
Jagadeesh.
The
discussion
was
aimed
at
current
procedure
followed
by
us,
the
process
that
can
be
initiated
and
probably
adopt
with
respect
to ′developing a research question and then writing an effective thesis proposal/protocol′ by PG students and Ph.D. candidates. The moderator illustrated the objectives for discussion as provided below:
- Discuss communication/interface between the research student and the guide in developing a project.
- Contribution of a research student in literature search and developing an idea.
- Writing the protocol, who does what?
Based on this, Dr. Jagadeesh asked the following questions to the panelists, in sequence with time for receiving questions/suggestions from the participants and panelists.
- How much training does a PG student need to develop and write a research/proposal or protocol?
- What is the role of a guide in imparting research concepts to a PG student?
- Should there be courses such as ′Research methods, Scientific writing, Ethics′, (nonbinding) in each and every University departments/colleges?
All
participants
were
excited
about
this
meaningful
workshop
and
shared
their
personal
experiences
on
the
types
of
research
activities
and
publications
undertaken
by
them.
It
was
evident
that
the
audience
enjoyed
themselves
and
had
a
good
grasp
of
the
issues
discussed
in
each
presentation
as
they
actively
contributed
to
the
panel
discussion.
Dr.
G.
Jagadeesh
distributed
tokens
of
appreciation
for
participants,
who
made
critical
suggestions
to
make
further
improvements
based
on
the
abovementioned
questions.
This
session
lasted
for
90
min
and
conclusions
were
obscure;
hence,
the
details
of
discussion
have
not
been
reported
here.
Toward
the
end
of
this
workshop,
the
participants
had
the
general
understandings
on
various
steps
involved
in
developing
a
research
protocol/proposal,
including
identifying
a
research
question/topic
to
writing
objectives,
developing
a
hypothesis
and
understanding
the
typical
format
and
elements
of
a
study
protocol
and
their
importance
in
driving
the
study
to
completion.
In
addition,
they
gained
insights
into
data
analysis
and
thesis
synthesis.
The
participants
also
learned
the
anatomy
of
a
research
paper
(IMRaD)
that
included
writing
an
effective
title
and
abstract.
The
participants
had
the
opportunity
to
acquaint
themselves
with
the
language
and
style
in
writing
a
research
paper
and
realized
that
writing
references
either
for
a
thesis
or
for
a
publication
is
not
a
casual
task.
It
was
stressed
by
most
of
the
speakers
that
a
casual
approach
in
manuscript
writing
may
also
reflect
a
casual
approach
in
experimental
work.
Finally,
the
participants
had
an
opportunity
to
learn
various
aspects
of
scientific
ethics.
Overall,
the
preconference
was
extremely
beneficial
to
students,
teachers
and
emerging
researchers.
The
audience
used
the
feedback
evaluation
form
to
rate
their
experiences
regarding
the
scientific
content
and
quality
of
presentations
as ′very satisfactory to satisfactory′; all participants agreed to attend such workshops organized in future frequently, at zone and state levels. The participants noted that the program was very hectic (since 15 presentations were delivered in < 8
h)
and
requested
to
increase
the
duration
of
the
program
as
well
as
discussion.
Copyright 2007 - Indian Journal of Pharmacology
|