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Tropical Journal of Pharmaceutical Research, Vol. 8, No. 4, Aug, 2009, pp. 297-302 Research Article Knowledge, Attitude and Practice of Commercial Drivers in Dar es Salaam with Regard to Medicines that Impair Driving Godeliver AB Kagashe* and Khamis Seleman Department of
Pharmaceutics, School of Pharmacy, Muhimbili University of Health and Allied
Sciences, PO Box 65577, Dar es Salaam, Tanzania Received: 29 June 2008 Code Number: pr09038 Abstract Purpose: The objective of this study was, first, to assess the knowledge,
attitude and practice of commercial drivers in Dar es Salaam with regard to
medicines that impair driving, and second, to evaluate the adequacy of
antihistamine label information. Key words: Driving impairment, Medication information, Antihistamines, Dar es Salaam INTRODUCTION Driving is a psychomotor activity that requires a combination of concentration and good visual and auditory functions. Several factors can affect driving including the use of alcohol and certain medications. The effect of alcohol on driving is well known1,2. Most drivers are at least aware that it is dangerous to drink and drive and in many countries driving while drunk is illegal2. The effect of medicines on driving on the other hand is not well known to the public and to drivers in particular. Several studies have shown that a variety of medicines when taken can affect the mental and physical skills needed for safe driving. Some of these medicines include antihistamines which are well known for causing sedation and drowsiness4, antidepressants, benzodiazepines, antiepileptic drugs5,6. Others include antimalarials, for example, Sulphadoxine/Pyrimethamine (SP) which cause tiredness and depression, quinine and chloroquine which impair vision and hearing respectively7. When medicines affecting driving are being prescribed and or dispensed, it is always assumed that medical personnel will give all the necessary information and instructions to the patient. Studies however, have shown that actually counseling of patients on medications is not done properly and in some cases it is not done at all8,9. In case of over the counter drugs, it is assumed that the patient will read the label containing a warning on driving and follow the instructions properly. Studies, however, have shown that patients do not often read labels on medicine packages and even if they read sometimes, they do not understand10. At times the warnings are ambiguous. Users of most of these medicines are ambulatory patients who can drive a car. This puts them at risk if proper instructions or warning are not provided by the health workers in particular dispensers of medicines in pharmacies. In Tanzania, to the best of our knowledge, no studies that have been undertaken to assess medicine use and driving. This work therefore was carried out to assess the knowledge, attitudes and practice of commercial drivers in Dar es Salaam Region regarding medicines impairing driving. The study also investigated whether drivers obtain information and warning from prescribers/dispensers about the driving impairment effect of medicines. In addition the study evaluated the adequacy of antihistamine label information. METHODS This was a cross sectional studywhich involved the following drivers in Dar es Salaam region;drivers of commuter buses known as dala dala within Dar es Salaam city, taxi drivers,long distance lorry driversandinter- regional bus drivers. Drivers from each of the above categories were interviewed face to face using questionnaire after obtaining a verbal consent from the individual driver. The questionnaire was developed and pre-tested in 15 drivers. Drivers to be interviewed were selected randomly at their packing stations Ethical clearance for the study was obtained from the School of Pharmacy Research Committee, a subcommittee of Muhimbili University of Health and Allied Sciences (MUHAS) Research and Publication Committee, which has the mandate for granting ethical approval. Permission to interview drivers was obtained from the Drivers Association in Dar es Salaam. Data analysis was carried out using Epi Info software, version 6. RESULTS Three hundred and three drivers (303) out of 384 drivers approached for the study agreed to participate. All 303 drivers interviewed were males (Table 1). Forty two percent were in the age range of 36-45 years. Their driving experience was from 2 to more than 10 years with most drivers (63%) having more than six years of experience. Fifty one percent (51.5%) of drivers were unaware of the existence of medicines that impair driving. Table 2 shows medicines that impair driving as mentioned by drivers. Cough medications were high on the list (64.7%). Table 1: Demographic features of the study population
Table 2: Medicines affecting driving as mentioned by drivers (n=303)
Regarding the effects that impaired driving drowsiness (72%) due to medications was mentioned by many drivers. Forty one percent mentioned fatigue as one of the effects impairing driving while 12% mentioned blurred vision. Table 3 shows the type of side effects experienced most and the type of medications taken. For cough syrups, drowsiness (38%) was common while with antimalarials fatigue (36%) was the main effect felt. When asked whether they read labels of medications. Sixty eight percent of drivers said they read labels on containers of medicines. Forty two percent (42%) of the drivers read labels in order to get information on how to use the medication, while 42% looked out for a warning and about 4% looked out for the content. Most drivers (52%) said they did not know what to do when affected by medication-impaired driving. Analysis of information on labels of different brands of medications for cough and colds, revealed that brands with the same concentration of the active ingredient affecting driving had different instructions/warnings on driving. Some products carried the warning while others of the same concentration did not. The products examined contained the same antihistamines of the same strength (Table 4). Table 3: Side effects experienced by those who took cough syrups and antimalarial medicines
DISCUSSION Use of medicines that impair driving was reported among the population of drivers studied. Drivers who were aware of the existence of medicines that impair driving had this knowledge from experience, i.e., they had used the medicines and they were affected. Cough syrups were the most mentioned drugs. Some drivers were able to mention specific brands of cough syrups all of which were found to contain antihistamines on their labels. This finding is in agreement with other studies which have tested the effects of antihistamine on driving performance 3. Use of sedating medicines has also been shown to be a risk factor in drowsy -driving crash11. The results for medicines said to affect driving are similar to the findings of McGwin et al who showed that non-steroidal anti-inflammatory drugs, benzodiazepines and angiotensin converting enzyme inhibitors were associated with increased risk of ‘at fault’ involvement in vehicle crashes12. In our study, nearly three out of ten of the drivers mentioned analgesics as causing driving impairment. The psychotropic effect of analgesics has also been indicated as a major causal factor of driving impairment13. Table 4: Information on labels of containers of medicines containing antihistamine
With regard to adverse effects following medications, drowsiness was the most mentioned effect and fatigue was next. These two have been classified as behavior factors that can reduce capability to drive on a short term basis and therefore cause road traffic crashes14. Different therapeutic groups of medicines had different adverse effects that impaired driving most. For cough syrups, the most mentioned effect was drowsiness (38.3%). This may be due to the fact that most of these cough medicines contained antihistamines which have been shown to cause sedation. For antimalarials, the most mentioned effect was fatigue and blurred vision and among medicines mentioned were quinine and chloroquine. These two drugs have been documented to affect driving due to these effects 7. Only a few of the drivers admitted to have received warnings from dispensers about effects of medicines on driving. About half said that they had never been warned on the effects of medicines on driving. This suggests that prescribers/dispensers do not give adequate medication information to patients. Prescribing guidelines laid down by International Pharmaceutical Federation (FIP)15 state that if the drug is known to impair performance, then it is better to look for alternatives. If no alternative is possible then the patient must be advised accordingly. According to the present results patients were not advised on driving impairment of these medications. Similar results were shown in a study done by Brooke et al16 where patients were not informed about their fitness to drive. It may be assumed that the prescribers/dispensers were not aware of the dangers involved and hence the need to inform the patient. A study by Kelly et al17 showed that doctors knowledge on driving restrictions and actions to be taken if a patient was not fit to drive was very poor. Less than half of the drivers said that they read the labels but they only looked out for instructions on how to use the medication. Some looked out for warning but could not tell what the warning was against, while several others did not bother reading labels. This puts the drivers at risk especially when they obtain over-the-counter (OTC) medicines Half of the drivers did not know what to do when they took medicines that affect driving. This shows that these drivers were not informed and that can be dangerous if the driver decided to engage in driving while under the influence of these medications. The fact that there was a great variation in the display of warning information is of great concern. Wrong labeling can cause problems to the user, in this case the driver who may not take the necessary precautions CONCLUSION Medicines that affect driving are a problem to the society. Road traffic accidents are on the increase in Tanzania and one of the causal factors may be the intake of medicines that impair driving. This study has shown that most of the drivers interviewed had taken medication that could have affected their driving but did not know what to do when the medication affected adversely. This indicates that drivers were not well informed about the effects of these medicines and the actions to be taken. There is a need therefore to inform the public and raise awareness about medications impairing driving. Proper labeling of medicines affecting driving is needed in order to ensure safe use of these medicines. REFERENCES
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