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African Journal of Reproductive Health
Women's Health and Action Research Centre
ISSN: 1118-4841
Vol. 15, Num. 4, 2011, pp. 20-23
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African Journal of Reproductive Health, Vol. 15, No. 4, Dec, 2011, pp. 20-23
Original Research Article
Intraocular
pressure in pregnant and non-pregnant Nigerian women
Pression intraoculaire chez les femmes nigérianes
enceintes et non enceintes
Ebeigbe J
A1, Ebeigbe P N2 and Ighoroje A D A3
1Department of Optometry,
Faculty of Life Sciences, University of Benin, Benin City;
2Department
of Obstetrics and Gyneacology, College of Health Sciences, Delta State
University, Abraka;
3Department of Physiology, School of Basic
Medical Sciences, University of Benin, Benin City, Nigeria
*For correspondence: Email: jenniferebeigbe@yahoo.com Tel: +2348023470140
Code Number: rh11046
Abstract
A
number of hormones are known to affect intraocular pressure. Of these, the
female sex hormones are the predominant ones to cause variations in intraocular
pressure. The aim of this study was to determine if variation in sex hormones
in pregnancy affects intraocular pressure. This study was a longitudinal one.
117 pregnant women aged 20 to 35 years in their first trimester of pregnancy
were followed longitudinally throughout the course of pregnancy, and six weeks
post partum. One hundred non pregnant women with a regular menstrual cycle of
26-29 days were also recruited and examined for changes in intraocular
pressure. Intraocular pressure was measured with the handheld Kowa applanation
tonometer. Mean Intraocular Pressure (MIOP) was 14.7 ± 2.2 mmHg, 13.2 ± 2.0
mmHg and 11.0 ± 1.3 mmHg in the three trimesters respectively. There was thus a
fall in Intraocular Pressure during pregnancy and this was highly statistically
significant (P<0.0001). At 6 weeks postpartum MIOP increased to 14.2 ± 1.8
mmHg. The difference between the mean values of Intraocular Pressure in the
third trimester and 6 weeks postpartum was also statistically significant
P<0.0001.Intraocular pressure decreased as pregnancy advanced.
Postpartum, there was increase in intraocular pressure to near pre pregnant
level. The difference in mean IOP between the pregnant and non pregnant women
was statistically significant (P<0.05) (Afr J Reprod Health 2011;
15[4]: 20-23).
Résumé
Il
est connu que certaines hormones affectent la pression intraoculaire. Parmi
elles, les hormones sexuelles de la femme constituent les hormones
prédominantes pour provoquer des variations dans la pression intraoculaire.
Cette étude a pour objectif de déterminer si la variation des hormones
sexuelles dans la grossesse affecte la pression intra oculaire. Il sagissait
dune étude longitudinale. Cent dix-sept femmes enceintes âgées de 20 à 35 ans
qui étaient dans leur premier trimestre de grossesse ont été suivies de manière
longitudinale tout au long de la grossesse et six semaines post-partum. Nous
avons aussi recruté et examiné cent femmes enceintes qui avaient un cycle
menstruel régulier de 26 à 29 jours pour déterminer les modifications dans la
pression intraoculaire. La pression intraoculaire a été mesurée à laide de
laplanométrie à main de Kowa. La pression Intraoculaire Moyenne (PIM) était
de 14,7±2,2mmHg, 13,2±2,0 mmHget 11,0±1,3 mmHgdans les trois trimestres
respectivement. Il y avait ainsi une chute de la Pression Intraoculaire
pendant la grossesse, ce qui était hautement statistiquement significatif
(p<0,0001). A la fin de six semaines de postpartum, la PIM a augmenté
jusquà 14,2±1,8mmHg. La différence entre les valeurs moyennes de la pression
intraoculaire dans le troisième semestre et le postpartum de de six semaines
était aussi statistiquement significative (p<0,0001). La pression intra
oculaire a diminué au fur et à mesure que la grossesse avançait. Il y avait une
augmentation de la pression intraoculaire qui atteignait presque le niveau de
pré-grossesse. La différence par rapport à la PIO moyenne entre les femmes
enceintes et les femmes non-enceintes statistiquement significative
(p<0,05). (Afr J Reprod Health 2011;
15[4]: 20-23).
Keywords: Intraocular
pressure, Hormone, Postpartum, Pregnancy, Estrogen
Introduction
Pregnancy
is the period during which a woman carries a developing foetus in the uterus1.
This period is from conception to the delivery of the foetus. The duration of
pregnancy is about 280 days or 40 weeks or 9 months and 7days which is counted
from the first day of the last menstrual cycle1-3.
The state of pregnancy
results in a lot of hormonal changes in the body and
the eyes are no exception. These ocular changes could be physiologic, examples
include changes in refractive state, visual fields, cornea sensitivity,
intraocular pressure and dry eye. Pathologic changes include central serous
chorio retinopathy. There could also be a modification of a pre-existing
condition. The most significant modified pre-existing condition is diabetic
retinopathy which worsens during pregnancy. Glaucoma on the other hand has
been reported to improve during pregnancy4-8.
Most of the
physiologic changes that occur as a result of pregnancy are usually marked in
the third trimester. This is because at this period hormonal activity is at its
peak9. A pregnant woman at term is said to produce as much estrogen
as a non pregnant woman would in three years10. However, these
changes are transient because several weeks postpartum, all hormonal activities
return to near pre-pregnant state9,10.
Raised
intraocular pressure (IOP) is known to be a risk factor for glaucoma. A number
of hormones are known to affect intraocular pressure. Of these, the female sex
hormones are the predominant ones to cause variations in intraocular pressure.
This is because sex hormones are steroids and steroids have an effect on salt
and water metabolism. This leads to increase in total body fluid content which builds up in the
spaces between cells causing water retention11,12.
Glaucoma
is most commonly found in adults over the age of 40, but will occasionally
occur in females of childbearing age. Often, women will have had preexisting
glaucoma which originally began in childhood or glaucoma secondary to other
conditions such as uveitis or diabetes. The treatment of glaucoma in and around
pregnancy offers the unique challenge of balancing the risk of vision loss to
the mother with potential harm to the fetus or newborn 13.
Previous
studies14-16 on ocular changes in Caucasian women during pregnancy
showed that because of hormonal influences, pregnancy brings about changes in
refractive status, cornea sensitivity, visual acuity and intraocular pressure.
No Nigerian study exists on changes in intraocular pressure in pregnant
women.
Methods
This
study was a longitudinal one. One hundred and seventeen pregnant women in their
first trimester of pregnancy were followed longitudinally throughout the course
of pregnancy, and six weeks post partum.
The women were recruited between the eight and tenth weeks of pregnancy.
The 117 pregnant
women were recruited at the antenatal clinic of the Department of Obstetrics
and Gynaecology of the University of Benin Teaching Hospital (UBTH). Ethical
approval was obtained from the ethics committee and informed consent from the
women. This was obtained by having the women sign a written consent form after
the study was explained to them. The women were screened for systemic and
ocular diseases and these were used as the exclusion criteria for participation
in the study.
After measuring their
systolic and diastolic blood pressures, Ophthalmoscopy was done to rule out
any posterior segment diseases. Intraocular pressure was measured with the
hand-held Kowa applanation tonometer. Examination was done between the hours
of 8am to 10am on every anti-natal clinic visit. This was to avoid diurnal
variation in IOP.
Test was carried out
in the first, second and third trimesters of pregnancy and 6 weeks post partum.
However, 17 of the pregnant women were lost to follow up either because they
did not attend their post natal clinic appointment or did not bring their
babies to UBTH for immunization. Some of them also attended UBTH only for the
expert antenatal care and never had the intension of giving birth there,
probably because they were from out of town. Postpartum, only 100 women were
part of the study. One hundred non pregnant women, also of the same age were
recruited and examined for changes in intraocular pressure. The average of the
data was computed as mean values.
Sample
size determination
The
sample size was determined using the Leshe-Kish formula for single proportion10.
This is stated below:
where
n = desired sample size, z = standard normal deviate corresponding to 95%
confidence level, p = vertical transmission rate of intraocular pressure (IOP)
i.e 3%, q=1-p and d= degree of accuracy (0.05 or 95%). This gave an
approximate value of n= 45.
Data
analysis
The data obtained was analyzed with GraphPad InStat
(Statistical graphics incorporation, USA). Comparison of data among the
different groups was performed with one-way analysis of variance (ANOVA), and
test between groups with students t-test.
Results
There
was a fall in Intraocular Pressure across the three trimesters of pregnancy and
this was highly statistically significant (P<0.0001). At 6 weeks
postpartum, mean Intraocular Pressure rose to 14.2 ± 1.8 mmHg. The difference
between the mean values of Intraocular Pressure in the third trimester and 6
weeks postpartum was also statistically significant P<0.0001 (t test,
t=16.47 with 2017 degrees of freedom) (Table 1).
For the non pregnant women, mean intraocular pressure
was high during the follicular phase, gradually declined towards ovulation and
rose again in the luteal phase (Table 2). The difference in mean IOP between
pregnant and non pregnant women was statistically significant (t = 7.97, p<0.05).
Table 1: Intraocular pressure in pregnancy and postpartum
Statistics |
First |
Second |
Third |
Postpartum |
Mean IOP (mmHg) |
14.7 |
13.2 |
11.0 |
14.2 |
SD |
2.2 |
2.0 |
1.3 |
1.8 |
SEM |
0.24 |
0.22 |
0.14 |
0.19 |
N |
100 |
100 |
100 |
100 |
SD = standard deviation, SEM
= standard error of mean, N= number of subjects
Table 2: Intraocular pressure in non-pregnant women
Statistics |
Follicular |
Ovulation |
Luteal |
Mean IOP (mmHg) |
16.6 |
15.0 |
16.0 |
SD |
1.6 |
1.7 |
1.5 |
SEM |
0.23 |
0.24 |
0.21 |
N |
100 |
100 |
100 |
SD = standard deviation,
SEM = standard error of mean, N= number of subjects
Discussion
The
changes in intraocular pressure (IOP) during pregnancy were significant in this
study. IOP was found to reduce consistently as the pregnancy advanced, with the
lowest pressure in the third trimester. This confirms the ocular hypotensive
effect of pregnancy. Six weeks postpartum, the intraocular pressure had risen
to near pre pregnant values. The finding that the third trimester of pregnancy
has an ocular hypotensive effect is consistent with other studies17-20.
Philips and Gore22 reported no significant difference in the ocular
hypotensive effect of late pregnancy in normotensive and hypertensive pregnant
women. The decreased IOP in the pregnant women would explain why pre-existing
glaucoma improves during pregnancy as reported by previous studies.
The physiological mechanism responsible for the
decreased in IOP during pregnancy is not well known. A number of mechanisms
have been postulated. One22 stated that the decreased IOP in
pregnancy is due to elevated hormonal levels which cause an increase in fluid
outflow conductance without altering the rate of fluid entry. However, it is
well documented that increased levels of progesterone and oestrogen that occur
in pregnancy cause dilation of the vessels of the circulatory system leading to
decreased arterial pressure and thus a reduction in aqueous humour production23.
The effects of relaxin could be another good
possibility22. During pregnancy, the release of the hormone relaxin,
causes a relaxation of the pelvic ligaments of the mother, so that the
sacroiliac joints become relatively limber and the symphysis pubis becomes
elastic. These changes make for easier passage of the fetus through the birth
canal. Philips and Gore22 suggested that this softening of ligaments
in late pregnancy might extend to the ligament of the corneo-scleral envelope
to produce reduced corneo-scleral rigidity and therefore cause a fall in IOP.
This could explain the reduced intraocular reported in this study. This
physiological softening of ligaments extending to the corneoscleral envelope is
reported to produce only an apparent fall in intraocular pressure. Evidence has
been presented previously to support the view that the concept of corneo-
scleral rigidity should be largely, if not completely, replaced by variations
in ocular volume or, more accurately, variations in surface area of the
corneoscleral envelope. Alternatively, improved uveoscleral outflow, which
results from the hormonal changes of late pregnancy, is a more likely
explanation for a true fall in pressure24.
Some studies 7,9,26 have stated that the
relative ocular hypotension in late pregnancy is probably not due to reduced
episcleral venous pressure. The finding of very similar ocular tension in
hypertensive and non-hypertensive groups of third trimester pregnant women by
Philip and Gore22, contrasts with the association between vascular
hypertension and open-angle glaucoma in elderly patients found in a previous
study14. The discrepancy is probably due to the presumed difference
in etiology between the two hypertensions, but difference in age may be
important. Many other possible explanations exist24. Further
research is needed in this aspect.
There were changes in mean IOP in the non pregnant
women. Previous studies24-25 had reported increase in IOP between 20th
and 22nd day. Some studies19,20 reported an increase
during the luteal phase of the cycle. While others24,25 reported an
increase during follicular and luteal phase. The influence of hormonal
fluctuations during the menstrual cycle on IOP is still to be clarified.
In summary, this study showed a gradual, statistically
significant fall in intraocular pressure during pregnancy. This ocular
hypotension was pronounced in the third trimester. This implies that pregnancy
could have beneficial effects on glaucoma. Pregnant women with glaucoma should
therefore be managed in conjunction with their eye care Practitioner so as to
properly monitor them to see if the state of pregnancy can maintain a normal
level of intraocular pressure without the administration of intraocular
pressure lowering drug.
Intraocular pressure varied during the different
phases of the menstrual cycle. This variation is significant and could help in
the screening for glaucoma.
This work is by no means exhaustive or conclusive, as
further research is needed in this area of study. Improved understanding of the
pathophysiology of ocular disease in pregnancy and the impact of pregnancy on
the course of pre-existing ocular disease offers the opportunity for meaningful
counselling of women who are pregnant or planning to become pregnant. Also,
this study has established baseline data on the pattern of intraocular pressure
changes in pregnant and non pregnant Nigerian women.
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