About Bioline  All Journals  Testimonials  Membership  News

Journal of Applied Sciences and Environmental Management
World Bank assisted National Agricultural Research Project (NARP) - University of Port Harcourt
ISSN: 1119-8362
Vol. 24, No. 8, 2020, pp. 1483-1488
Bioline Code: ja20215
Full paper language: English
Document type: Research Article
Document available free of charge

Journal of Applied Sciences and Environmental Management, Vol. 24, No. 8, 2020, pp. 1483-1488

 en Isolation and Characterization of Larvicidal Phenolic Acids from Kotschya thymodora check for this species in other resources Leaves


Malaria is a vector borne disease responsible for high morbidity, mortality and poverty in many tropical and subtropical countries. The disease is transmitted through a bite from an infected female Anopheles check for this species in other resources mosquito, amongst which Anopheles gambiae s.s check for this species in other resources serves as the most prevalent vector. The control of An. gambiae s.s population can therefore lead to a reduction in malaria spreading. Previous studies have reported the crude extracts of Kotschya thymodora to be active against the larvae of An. gambiae s.s and Culex quinquefasciatus check for this species in other resources . In this report the phytochemical study on the crude aqueous ethanolic extract of K. thymodora leaves led to isolation of vanillic acid (1) and protocatechuic acid (2). The structures of these compounds and mosquitoes larvicidal activity against An. gambiae s.s were established by using spectroscopic techniques and WHO protocol of 1996 respectively. The two phenolic acids exhibited a moderate mosquito larvicidal activity with LC50 of 77.35 μg/mL (vanillic acid, 1) and 62.4 μg/mL (protocatechuic acid, 2) after 48 hrs exposure time. This is the first report on the isolation of the two phenolic acids from plants belonging to the genus Kotschya and their larvicidal potential against An. gambiae s.s.

larvicidal activity; vanillic acid; protocatechuic acid; Anopheles gambiae s.s and Kotschya thymodora

© Copyright 2020 - Daniel et al.

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2024, Site last up-dated on 01-Sep-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Google Cloud Platform, GCP, Brazil