About Bioline  All Journals  Testimonials  Membership  News

Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 27, No. 3, 2020, pp. 53-60
Bioline Code: mj20030
Full paper language: English
Document type: Research Article
Document available free of charge

Malaysian Journal of Medical Sciences, Vol. 27, No. 3, 2020, pp. 53-60

 en Detailed Anatomical Volumetric Study of Deep Nuclei of Brain and Other Structures Between Parkinson’s Disease Patients Who Had Deep Brain Stimulation and Control Group
Goh, Chin Hwee; Abdullah, Johari Yap; Idris, Zamzuri; Ghani, Abdul Rahman Izaini; Abdullah, Jafri Malin; Wong, Albert Sii Hieng; Tharakan, John & Win, Salmah Mar


Background: Deep brain stimulation (DBS) was pioneered by Neuroscience team of Hospital Universiti Sains Malaysia (HUSM) nearly a decade ago to treat advanced medically refractory idiopathic Parkinson’s disease (IPD) patients.
Objectives: Brain volume reduction occurs with age, especially in Parkinson plus syndrome or psychiatric disorders. We searched to define the degree of volume discrepancy in advanced IPD patients and correlate the anatomical volumetric changes to motor symptoms and cognitive function.
Methods: We determined the magnetic resonance imaging (MRI)-based volumetry of deep brain nuclei and brain structures of DBS-IPD group and matched controls.
Results: DBS-IPD group had significant deep nuclei atrophy and volume discrepancy, yet none had cognitive or psychobehavioural disturbances. Globus pallidus volume showed positive correlation to higher mental function.
Conclusion: The morphometric changes and clinical severity discrepancy in IPD may imply a more complex degenerative mechanism involving multiple neural pathways. Such alteration could be early changes before clinical manifestation.

brain volumetry; brain morphometry; Parkinson’s disease; basal ganglia; globus pallidus; subthalamic nucleus

© Copyright 2020 - Penerbit Universiti Sains Malaysia
Alternative site location:

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2024, Site last up-dated on 01-Sep-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Google Cloud Platform, GCP, Brazil