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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 106, No. 7, 2011
Bioline Code: oc11166
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 106, No. 7, 2011

 en Ultrasound versus biological markers in the evaluation of periportal fibrosis in human Schistosoma mansoni check for this species in other resources
Domingues, Ana Lúcia Coutinho; de Medeiros, Tibério Batista & Lopes, Edmundo Pessoa de Almeida


In this paper, the authors review the literature and share their experience of the principal biological markers of fibrosis for the evaluation of periportal fibrosis check for this species in other resources (PPF) caused by mansoni schistosomiasis check for this species in other resources . These biological markers are compared to diagnostic ultrasound (US) scans as means of grading PPF. We also review procollagen type I and III, collagen type IV, laminin, hyaluronic acid (HA), immunoglobulin G, platelets, aspartate aminotransferase to platelet ratio index (APRI) and gamma-glutamyl transpeptidase as markers of the disease. Although there are several good markers for evaluating PPF and portal hypertension, such as HA, platelets or APRI, none can yet replace US. These markers may, however, be used to identify patients at greater risk of developing advanced disease in endemic areas and determine who will need further care and US studies.

schistosomiasis mansoni; ultrasound; fibrosis markers; HS schistosomiasis; liver fibrosis

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