The hypothesis that granuloma modulation and disease abatement in chronic
infection with Schistosoma japonicum
could be ascribed to antibody-mediated
effects on egg maturation and egg viability, arose from studies
performed with mice in the Philippines. This novel hypothesis has not
yet been integrated into the schistosomiasis literature despite being
formulated more than a decade ago. One reason for this is that the
phenomenon might be confined to S. japonicum, even S. japonicum
(Philippines).