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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 91, No. 2, 1996, pp. 217-224
Bioline Code: oc96043
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 91, No. 2, 1996, pp. 217-224

 en Trypanosoma cruzi Strains and Autonomic Nervous System Pathology in Experimental Chagas Disease
Marcia Maria de Souza; Sonia G Andrade; Aryon A Barbosa Jr; Raimunda Telma Macedo Santos; Venancio Avancini Ferreira Alves & Zilton A Andrade


Lesions involving the sympathetic (para-vertebral ganglia)
and para-sympathetic ganglia of intestines (Auerbach plexus) 
and heart (right atrial  ganglia) were comparatively analyzed
in mice infected with either of three different strain types
of Trypanosoma cruzi, during acute and chronic infection, 
in an attempt to understand the influence of parasite strain
in causing autonomic nervous system pathology. Ganglionar
involvement with neuronal destruction appeared related to
inflammation, which most of the times extended from
neighboring adipose and  cardiac, smooth and striated muscular
tissues. Intraganglionic parasitism was exceptional.
Inflammation involving peripheral  nervous tissue exhibited a
focal character and its variability in the several groups
examined appeared unpredictable. Although lesions were
generally more severe with the Y strain, comparative
qualitative study did not allow the conclusion, under the
present experimental conditions,  that one strain was more
pathogenic to the autonomic nervous system than others. No
special tropism of the parasites from any strain toward
autonomic ganglia was disclosed.

Trypanosoma cruzi strain types autonomic nervous system

© Copyright 1996 Fundacao Oswaldo Cruz
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