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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 91, No. 2, 1996, pp. 225-229
Bioline Code: oc96044
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 91, No. 2, 1996, pp. 225-229

 en Tumor Necrosis Factor-alpha in Human American Tegumentary Leishmaniasis
Alda Maria da-Cruz; Marcia Pereira de Oliveira; Paula Mello de Luca; Sergio CF Mendonca & Sergio G Coutinho


Tumor necrosis factor-alpha (TNF-alpha) is a cytokine
produced by activated macrophages and other cells. In order to
verify whether the serum levels of TNF-alpha in American
tegumentary leishmaniasis patients are associated with the
process of cure or aggravation of the disease, 41 patients
were studied: 26 cases of cutaneous leishmaniasis (CL) and 15
of mucocutaneous leishmaniasis (MCL). During active disease
the serum levels of  TNF-alpha  of MCL patients were
significantly higher than those of  CL patients and control
subjects (healthy individuals and cutaneous lesions from other
etiologies). The MCL patients had serum titers of  TNF-alpha
significantly lower at the end of antimonial therapy than
before therapy. After a six-month follow-up, the MCL patients
had serum levels of  TNF-alpha similar to those observed at
the end of the therapy as well as to those of CL patients and
control subjects. No significant variation in the serum levels
of TNF-alpha was observed in CL patients throughout the study
period (before, at the end of therapy and after a six-month
follow-up). The possible relationship between the high
TNF-alpha serum levels and severity of the disease is

TNF-alpha cytokine tegumentary leishmaniasis Leishmania braziliensis

© Copyright 1996 Fundacao Oswaldo Cruz
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