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Indian Journal of Occupational and Environmental Medicine
Medknow Publications
ISSN: 0973-2284
EISSN: 0973-2284
Vol. 10, No. 2, 2006, pp. 78-81
Bioline Code: oe06017
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Occupational and Environmental Medicine, Vol. 10, No. 2, 2006, pp. 78-81

 en Assessment of functional integrity of liver among workers exposed to soluble nickel compounds during nickel plating
Kalahasthi Ravi Babu, R RajmohanH, K RajanB

Abstract

The present study investigates the functional integrity of liver among workers exposed to nickel during nickel-plating process. The functional integrity of liver was assessed in 69 workers who are exposed to nickel during nickel plating and considered as nickel-exposed workers; and 50 administrative workers residing in same city, but away from the place of work of study group, were considered as control group. The level of urine nickel was measured by using a flameless atomic absorption spectrophotometer. Using kits supplied by Bayer Diagnostics, we determined serum markers of liver function tests.
Results: The levels of urine nickel were significantly increased in high-and moderate-exposure groups as compared to control group. The levels of serum transaminases -viz, alanine transaminase and aspartate transaminase-were significantly increased in nickel-exposed workers, who had high urine nickel levels as compared to control group. The level of serum albumin was negatively correlated with urine nickel levels. The levels of serum transaminases and serum γ- glutamyl- transpeptidase were positively and significantly correlated with urine nickel levels.
Conclusion: Results indicate that workers who had high urine nickel levels had a consistent effect on hepatic inflammatory function.

Keywords
Hepatotoxicity, nickel plating, urine nickel

 
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