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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996
EISSN: 1596-5996
Vol. 14, No. 7, 2015, pp. 1305-1310
Bioline Code: pr15172
Full paper language: English
Document type: Review Article
Document available free of charge

Tropical Journal of Pharmaceutical Research, Vol. 14, No. 7, 2015, pp. 1305-1310

 en Role of Endogenous Peptides and Enzymes in the Pathogenesis of Acute Pancreatitis: A Review
Reddy, Bonam Srinivasa; Bonigala, Sheba Dolly & Pandy, Vijayapandi


Acute pancreatitis is an inflammatory disease with the clinical manifestation of acute abdominal pain. Several factors are involved in the pathogenesis of acute pancreatitis. The exact mechanism(s) by which diverse etiological factors induce an attack are still unclear. However, one of the proposed mechanisms for induction of acute pancreatitis is auto-digestion of pancreatic tissues by unwanted activation of pancreatic digestive enzymes. The main objective of this review is to describe the pathogenesis mechanism of acute pancreatitis that are related to various inflammatory and pro-inflammatory mediators.

Acute pancreatitis; Pancreatic injury; Cytokines; Chemokines; Inflammation

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