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Tropical Journal of Pharmaceutical Research
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
ISSN: 1596-5996 EISSN: 1596-5996
Vol. 16, No. 3, 2017, pp. 577-580
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Bioline Code: pr17074
Full paper language: English
Document type: Research Article
Document available free of charge
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Tropical Journal of Pharmaceutical Research, Vol. 16, No. 3, 2017, pp. 577-580
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Anti-depressant effect of Paeonia lactiflora Pall extract in rats
Yu, Xiao-hui; Song, Tao; Hou, Xiao-li; Sui, Yong; Li, Yan-ling; Hu, Dan; Wang, Xiao-hong; Xiao, Zheng-zheng; Wang, Rui-ren; Wang, Jin & Wang, Zhen
Abstract
Purpose: To explore the effect of Paeonia lactiflora Pall. extract on depression in rats.
Methods: Various doses (150, 300 and 600 mg/kg) of Paeonia lactiflora Pall. extract (PLPE) were orally
administered to three groups of rats of 10 each, respectively, suffering from depression for 14 days.
Fluoxetine was used as positive control. Tail suspension, forced swimming and monoamine oxidase
(MAO) tests were carried out on the rats.
Results: A dose-dependent reduction in rat immobility was observed. The effect of PLPE at the highest
dose (600 mg/kg) was more potent than that of the reference antidepressant, fluoxetine. PLPE, at a
dose ≥ 150 mg/kg significantly inhibited MAO A activity in rat whole brain in a dose-dependent manner
(p < 0.01); however, only oral administration of PLPE at a dose of 600 mg/kg produced observable MAO
B inhibitory activity in rat brain (p < 0.01). Only fluoxetine showed a tendency to inhibit both MAO A and
B activities in animal brain. Neither PLPE nor fluoxetine, at the doses tested, produced significant
effects on locomotor activity.
Conclusion: The results suggest that Paeonia lactiflora Pall is a potential agent for the treatment of
depression in humans.
Keywords
Paeonia lactiflora; Depression; Tail suspension test; Forced swimming test
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