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Actinomycetes
University of Udine, Mycology Department
ISSN: 0732-0574
Vol. 1, No. 2, 1990, pp. 43-47
Bioline Code: ac90007
Full paper language: English
Document type: Research Article
Document available free of charge

Actinomycetes, Vol. 1, No. 2, 1990, pp. 43-47

 en Donor-dependent Stimulation of Superoxide Output by Muramyl Dipeptide (MDP) in Human Granulocytes and Synergism of MDP with Lipopolysaccharide
I. Tarnok & Zs. Tarnok

Abstract

In the course of an investigation we observed: (1) a donor- dependent stimulation of the superoxide output by MDP and thus, this compound must be characterized as active in this respect. MDP activated mainly the second phase of the superoxide output; (2) no beneficial effect of a preincubation ("priming") with MDP prior to the addition of a second challenge (e.g., LPS). That means, preincubation with MDP did not lead to a higher superoxide production with endotoxin. Controls, preincubated with buffer instead of MDP showed the same superoxide output; thus, chemiluminescence counts might increase without a "priming" compound as well; (3) a synergism between MDP and LPS. The superoxide output was significantly higher when both substances were added simultaneously than when they were applied alone.

 
© Copyright 1990 C.E.T.A., The International Centre for Theoretical and Applied Ecology, Gorizia

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