Actinomycetes, Vol. 5, Part 1, 14-22, 1993
Purine metabolites as interspecific stimulators of setomimycin formation
by Streptomyces aurantiacus
U. GRAFE, W. IHN and I. ERITT
Code Number: AC94004
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ABSTRACT. The formation of a yellow pigment (setomimycin) is
strongly stimulated in surface cultures of S. aurantiacus JA
4570/5 by cell-free culture broth of Streptomyces griseus and
some other streptomyces strains. Reduced
nicotinamide-adenine-dinucleotide (NADH) was identified as one
of the inducing principles from S.griseus JA 8407/299, but
other purines, such as NAD(P)(H), adenosine and guanosine
phosphates, and pyridoxal 5'-phosphate as well, displayed the
same effect. The results suggest that actinomycetes secrete
purines into the medium and that these nucleotides and
cofactors could regulate secondary metabolite formation.
Copyright 1994 C. E. T. A.
