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Indian Journal of Cancer
Medknow Publications on behalf of Indian Cancer Society
ISSN: 0019-509X
EISSN: 1998-4774
Vol. 40, No. 4, 2003, pp. 144-147
Bioline Code: cn03025
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Cancer, Vol. 40, No. 4, 2003, pp. 144-147

 en Case Report - Chronic Myeloid Leukemia Presenting with Absence of Basophils and Marked Dyspoiesis
Anand M, Kumar R, Kumar L, Barge S, Singh S

Abstract

A 61-year old woman presented to us with fever, weakness and ecchymotic patches for one year. She had leucocytosis, anemia and thrombocytopenia. Peripheral blood smear showed 62% neutrophils, 32% myelocytes and metamyelocytes, 2% promyelocytes, 1% blasts, 2% monocytes, 1% lymphocytes but no basophils and marked dyspoiesis. Bone marrow picture was essentially the same. A diagnosis of atypical chronic myeloid leukemia was suggested. The correct diagnosis of chronic myeloid leukemia - accelerated phase was, however, made on cytogenetic analysis which showed Philadelphia chromosome (Ph) and isochromosome 17q [i(17q)]. This case describes a rare and diagnostically difficult presentation of CML arising out of a combination of prominent dyspoiesis and near absence of peripheral blood basophils.

Keywords
CML, aCML, Basophil, Dyspoiesis

 
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Alternative site location: http://www.indianjcancer.com/

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