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Indian Journal of Cancer
Medknow Publications on behalf of Indian Cancer Society
ISSN: 0019-509X
EISSN: 1998-4774
Vol. 42, No. 2, 2005, pp. 104-106
Bioline Code: cn05021
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Cancer, Vol. 42, No. 2, 2005, pp. 104-106

 en Case Report - T- cell prolymphocytic leukemia - A rare case
Ghosh Sharmila, Advani Suresh H

Abstract

T- cell Prolymhocytic leukemia (T-PLL) is a rare mature post-thymic T-cell malignancy that is usually reported in the elderly and follows an aggressive course. A 68 year old male presented with a history of weakness and weight loss of two months duration. Clinical examination revealed pallor, enlarged cervical and axillary lymph nodes and splenomegaly. He also had a maculo- papular skin rash. There was marked leucocytosis, anemia and thrombocytopenia (WBC 445 x103/ml, Hb 8.5gm/dl, Platelet 25x103/µl) with 60% prolymphocytes in the peripheral blood. Bone marrow was hypercellular with an excess of prolymphocytes. Flow cytometric analysis of the bone marrow showed positivity for CD2, CD3, CD4, CD5 and CD7.

T- PLL is a rare T cell disorder with characteristic clinical and laboratory features.Currently, no optimal treatment exists although there has been some success with 2′- deoxycoformycin or Campath-1H

Keywords
Prolymphocytes, Leukemia, T cell, Lymphoproliferative

 
© Copyright 2005 Indian Journal of Cancer.
Alternative site location: http://www.indianjcancer.com/

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