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Indian Journal of Cancer
Medknow Publications on behalf of Indian Cancer Society
ISSN: 0019-509X
EISSN: 1998-4774
Vol. 46, No. 4, 2009, pp. 288-296
Bioline Code: cn09070
Full paper language: English
Document type: Review Article
Document available free of charge

Indian Journal of Cancer, Vol. 46, No. 4, 2009, pp. 288-296

 en Pancreatic carcinogenesis: The impact of chronic pancreatitis and its clinical relevance
Shrikhande, S V; Barreto, G & Koliopanos, A

Abstract

Pancreatic cancer is a devastating disease with a dismal prognosis and early detection remains a challenge. On the background that inflammation is one of the key steps in the development of cancer, it is natural that chronic pancreatitis is considered as one of the etiological factors for the development of pancreatic cancer. However, the process of pancreatic carcinogenesis is a multifactorial phenomenon rather than a process that evolves solely via inflammation. This review attempts to put into perspective the association between different etiological forms of chronic pancreatitis and pancreatic cancer, and the diverse mechanisms operational in the process of pancreatic carcinogenesis. Furthermore, the clinical relevance of the current understanding of the relationship between chronic pancreatitis and pancreatic cancer, especially with regard to the pancreatic head mass of uncertain etiology, is discussed in this review.

Keywords
Chronic pancreatitis, pancreatic cancer, pancreatic carcinogenesis, inflammation, pancreatic head mass, risk of pancreatic cancer

 
© Copyright 2009 Indian Journal of Cancer.
Alternative site location: http://www.indianjcancer.com/

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