search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


Indian Journal of Dermatology, Venereology and Leprology
Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)
ISSN: 0378-6323
EISSN: 0973-3922
Vol. 70, No. 1, 2004, pp. 1-9
Bioline Code: dv04001
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Dermatology, Venereology and Leprology, Vol. 70, No. 1, 2004, pp. 1-9

 en Immunomodulators in the treatment of psoriasis
Thappa Devinder Mohan , Laxmisha Chandrashekar

Abstract

The efficacy of cyclosporine and related drugs in the treatment of psoriasis was the key to the development of the concept that psoriasis is an immune mediated disorder. These therapies demonstrably reduce the number of activated T-lymphocytes, which correlates with clinical remission. Monoclonal antibodies directed against key components of the inflammatory process have been studied in an attempt to produce safer, more effective and selective immunosuppressive agents. This review summarizes the information available on cyclosporine and related drugs, and cytokine therapy, including monoclonal antibodies directed against T-cell mediated inflammation. It should be realized that biologic therapies for psoriasis are very new and that efficacy and safety information from clinical trials is just becoming available.

Keywords
Cyclosporine, Mycophenolate mofetil, Leflunomide, Alefacept, Biologic therapy

 
© Copyright 2004 Indian Journal of Dermatology, Venereology, Leprology.
Alternative site location: http://www.ijdvl.com

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2022, Site last up-dated on 19-Jan-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil