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Indian Journal of Dermatology, Venereology and Leprology
Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)
ISSN: 0378-6323
EISSN: 0973-3922
Vol. 70, No. 1, 2004, pp. 20-24
Bioline Code: dv04005
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Dermatology, Venereology and Leprology, Vol. 70, No. 1, 2004, pp. 20-24

 en Adverse cutaneous drug reactions: Clinical pattern and causative agents in a tertiary care center in South India
Pudukadan David , Thappa Devinder Mohan

Abstract

Background: Adverse cutaneous drug reactions (ACDRs) are caused by a wide variety of agents. Aims: Our objective was to ascertain the clinical spectrum of ACDRs and the causative drugs in this part of India and to find any risk factors. Methods: Ninety patients with adverse cutaneous drug reactions were recruited for this study during 2001-2003. Hematological and biochemical investigations were done in all of them. The VDRL and HIV (ELISA) tests were performed where the underlying risk factors were present. Patch testing, intradermal testing and oral provocation tests were done wherever feasible. Results: The mean age of the patients with cutaneous drug eruptions was 37.06 years. Most of them (52.2%) were in the age group of 20-39 years. The male to female ratio was 0.87: 1. The most common eruptions observed were fixed drug eruption (31.1%) and maculopapular rash (12.2%), and the most common causes were co-trimoxazole (22.2%) and dapsone (17.7%). Conclusion: The pattern of ACDRs and the drugs causing them is remarkably different in our population. Knowledge of these drug eruptions, the causative drugs and the prognostic indicators is essential for the clinician.

Keywords
Adverse cutaneous drug reactions, Drug eruptions

 
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Alternative site location: http://www.ijdvl.com

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