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Indian Journal of Dermatology, Venereology and Leprology
Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)
ISSN: 0378-6323 EISSN: 0378-6323
Vol. 74, No. 5, 2008, pp. 481-484
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Bioline Code: dv08205
Full paper language: English
Document type: Case Report
Document available free of charge
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Indian Journal of Dermatology, Venereology and Leprology, Vol. 74, No. 5, 2008, pp. 481-484
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Methotrexate toxicity presenting as ulceration of psoriatic plaques: A report of two cases
Agarwal, Kishan Kumar; Nath, Amiya Kumar & Thappa, Devinder Mohan
Abstract
We describe two cases of methotrexate toxicity occurring due to inappropriate self-medication with the drug. The first patient was a 57-year-old man with plaque-type psoriasis on intermittent methotrexate therapy. He discontinued his medications for 2 months and had exacerbation of psoriasis for which he self-medicated with methotrexate following which he developed ulceration of the psoriatic plaques accompanied by bone marrow suppression. The second patient was a 68-year-old man with chronic plaque-type psoriasis for 20 years and was being treated with intermittent methotrexate for 15 years. He also self medicated with oral methotrexate 15 mg daily for 7 days for exacerbation of psoriasis and developed ulceration of the psoriatic plaques with bone marrow suppression and evidence of gastrointestinal erosions.
Keywords
Methotrexate toxicity, Psoriasis, Skin ulceration
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© Copyright 2008 Indian Journal of Dermatology, Venereology and Leprology. Alternative site location: http://www.ijdvl.com
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