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Indian Journal of Dermatology, Venereology and Leprology
Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)
ISSN: 0378-6323
EISSN: 0378-6323
Vol. 76, No. 1, 2010, pp. 7-13
Bioline Code: dv10003
Full paper language: English
Document type: Review Article
Document available free of charge

Indian Journal of Dermatology, Venereology and Leprology, Vol. 76, No. 1, 2010, pp. 7-13

 en Efficacy of low-dose isotretinoin in acne vulgaris
Sardana, Kabir & Garg, Vijay K.

Abstract

Low-dose isotretinoin (0.5 mg/kg/day) is a mode of therapy for mild to moderate grades of acne.We analyzed the various trials of this mode of therapy with or without combination with topical agents.We also statistically analyzed the results, efficacy and relapse rates of standard therapy in comparison with the low-dose therapy. Our analysis of the data revealed that the efficacy and relapse rates of low-dose isotretinoin in mild to moderate grades of acne is comparable with the standard regimen (1 mg/kg/day), which is given in the severe grade of acne vulgaris. Thus, the grade of acne vulgaris should dictate the dose of administration of isotretinoin and the standard dose of 1 mg/kg/day is an unnecessary overtreatment for mild to moderate grades of acne.

Keywords
Low-dose isotretinoin, acne vulgaris, efficacy

 
© Copyright 2010 Indian Journal of Dermatology, Venereology and Leprology.
Alternative site location: http://www.ijdvl.com

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