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Indian Journal of Dermatology, Venereology and Leprology
Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)
ISSN: 0378-6323
EISSN: 0378-6323
Vol. 76, No. 3, 2010, pp. 273-275
Bioline Code: dv10083
Full paper language: English
Document type: Case Report
Document available free of charge

Indian Journal of Dermatology, Venereology and Leprology, Vol. 76, No. 3, 2010, pp. 273-275

 en Nodular amelanotic melanoma
Nalamwar, Rashmi; Kharkar, Vidya; Mahajan, Sunanda; Chikhalkar, Sidhhi & Khopkar, Uday

Abstract

We report a case of 65-year-old male patient who presented with multiple erythematous papules coalescing to form a nodular mass over posterior aspect of right thigh of six months duration. His general and systemic examinations were within normal range except for right inguinal lymphadenopathy. Biopsy from the lesion was done, which showed diffuse infiltrate of nests of atypical melanocytes extending upto reticular dermis. Malignant cells were positive for S100 and human melanin black 45(HMB 45). Hence, a diagnosis of amelanotic melanoma (AM) - Clarke level IV and TNM stage III was reached. MRI of involved leg showed fungating soft tissue mass in the posterolateral aspect of right thigh and metastatic right inguinal adenopathy. Fine needle aspiration cytology (FNAC) from the right inguinal nodes confirmed metastasis of melanoma. The patient was referred to oncosurgery department for further management.

Keywords
Amelanotic melanoma, HMB45, Immunohistochemistry, pigment melanin, pigmented rim or border, S100

 
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Alternative site location: http://www.ijdvl.com

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