About Bioline  All Journals  Testimonials  Membership  News

Indian Journal of Dermatology, Venereology and Leprology
Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)
ISSN: 0378-6323
EISSN: 0378-6323
Vol. 77, No. 6, 2012, pp. 673-676
Bioline Code: dv11204
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Dermatology, Venereology and Leprology, Vol. 77, No. 6, 2012, pp. 673-676

 en Therapeutic efficacy and safety of propylthiouracil in psoriasis: An open-label study
Gnanaraj, Pushpa; Malligarjunan, Hemamalini; Dayalan, Haripriya; Karthikeyan, Subashini & Narasimhan, Murali


Background: Psoriasis is a common hyperproliferative disorder of the skin associated with significant morbidity. Most of the drugs used in psoriasis provide only a temporary relief, whereas they are riddled with potential toxicities and cost concerns. Hence, there is a constant need to explore newer, effective, orally administered, and cost-effective drugs with minimal adverse effects. In this scenario, propylthiouracil (PTU), an antithyroid thioureylene has been shown to be effective in psoriasis which satisfies the above criteria.
Aim: The objective of our study is to assess the clinical efficacy of PTU in psoriasis.
Methods: A total of 25 patients with plaque psoriasis were treated with oral PTU for 12 weeks. Clinical response was assessed using the “Psoriasis Area and Severity Index” (PASI) score. Routine blood analyses and thyroid function tests were carried out periodically during the study.
Results: Oral PTU produced significant clearing of lesions at 6 weeks and 12 weeks of the study period in all patients, as demonstrated by the reduction in PASI scores (33.9% in 6 weeks and 74.1% reduction in 12 weeks). Four patients experienced near complete clearing of the lesions. One patient developed mild elevation of liver enzymes which reversed on withdrawal of PTU. None of the patients had hypothyroidism or cytopenias.
Conclusion: PTU significantly clears the lesions in psoriasis with minimal adverse effects. Hence, it can be considered as a therapeutic option in psoriasis, especially when the standard drugs cannot be used due to their toxicities or forbidding cost.

Antithyroid agents, hyperthyroidism, hyperproliferation, propylthiouracil, psoriasis

© Copyright 2011 Indian Journal of Dermatology, Venereology, and Leprology.
Alternative site location:

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2024, Site last up-dated on 01-Sep-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Google Cloud Platform, GCP, Brazil