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Electronic Journal of Biotechnology
Universidad Católica de Valparaíso
ISSN: 0717-3458
Vol. 1, No. 2, 1998, pp. 55-64
Bioline Code: ej98009
Full paper language: English
Document type: Review Article
Document available free of charge

Electronic Journal of Biotechnology, Vol. 1, No. 2, 1998, pp. 55-64

 en Ion pumps as targets for therapeutic intervention: Old and new paradigms
Perlin, David S.

Abstract

The development of an effective target for therapeutic intervention remains a critical part of the drug discovery process. One such target class is the P-type ion translocating ATPases, which include the Na+,K+-ATPase of cardiac cells and the H+,K+-ATPase of gastric parietal cells. These enzymes serve as selective targets for digoxin and omeprazole, which are used to treat heart disease and gastrointestinal ulcers, and are two of the leading prescribed therapeutics worldwide. It is the exquisite selectivity that can be achieved between family members that continues to make the P-type enzymes desirable targets for developing new therapeutics including a new generation of antiulcer therapeutic and a new class of antifungal therapeutic.

Keywords
Ion pumps, Therapeutics, Oeprazole, Digoxin, Antifungal

 
© 1998 by Universidad Católica de Valparaíso -- Chile
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