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European Journal of General Medicine
Medical Investigations Society
ISSN: 1304-3897
Vol. 1, No. 3, 2004, pp. 37-42
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Bioline Code: gm04030
Full paper language: English
Document type: Research Article
Document available free of charge
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European Journal of General Medicine, Vol. 1, No. 3, 2004, pp. 37-42
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PROTECTIVE EFFECTS OF QUERCETIN, A FLAVONOID ANTIOXIDANT, IN ABSOLUTE ETHANOL-INDUCED ACUT GASTRIC ULCER
Ömer Coskun, Mehmet Kanter, Ferah Armutçu, Kurtulus Çetin, Betül Kaybolmaz, Ömer Yazgan
Abstract
Free radicals have been reported to be responsible for many ailments including gastroduodenal ulcers. Recent studies demonstrated that quercetin (QE) has an antioxidant effects on injuries caused by various toxic agents in different experimental models. In our study, we examined anti-ulcerogen and antioxidant effects of quercetin on ethanol-induced gastric lesions in rats. QE was administered intraperitoneally (i.p.) 50 mg/kg. It was found that pretreatment with QE significantly reduced ethanol-induced gastric damage and malondialdehyde levels, and significantly increased antioxidant enzyme activities. We conclude that QE clearly has antioxidant properties and that the protective effect of QE against ethanol-induced gastric mucosal lesion, at least in part, depends upon the reduction in the lipid peroxidation and an increase in the activity of antioxidant enzymes.
Keywords
Quercetin, ethanol, antioxidant enzymes, gastric damage, oxidative stress, rat
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