EFFECTS OF HIGH FAT DIET INDUCED OBESITY ON FEMALE RAT LIVERS (A HISTOCHEMICAL STUDY)

Aim: Obesity is an important, complex and chronic disease. Fatty diet is a significant factor causing obesity. It is known that obesity is associated with many chronic disorders such as Non-Alcoholic Fatty Liver Disease (NAFLD). However, mechanism of this event is yet unclear. In this study, it was purposed to examine histological effects of fatty diet induced obesity on liver from female obese rats.
Methods: Within scope of this aim, the obesity model was performed on animals of the study group, (Sprague Dawley rats), by feeding them with a diet comprised highly of fat, for a duration of 2-3 months. After this controlled nutritional process, livers were removed from all sacrificed rats and viewed under light microscope.
Results: In study groups' slides; mononuclear cell infiltrations, foci of necrosis, vascular dilatation, an increase in hepatic connective tissue, hepatocellular steatosis and shrinkage, additional cytoplasmic acidophily and nuclear density in the hepatocytes were determined. Finally, it was observed that fat-rich diet (%30) had caused a liver damage.
Conclusion: We think that our light microscopical finding would contribute clarifying the histopathological mechanism of obesity.