|
European Journal of General Medicine
Medical Investigations Society
ISSN: 1304-3897
Vol. 3, No. 3, 2006, pp. 102-107
|
Bioline Code: gm06022
Full paper language: English
Document type: Research Article
Document available free of charge
|
|
European Journal of General Medicine, Vol. 3, No. 3, 2006, pp. 102-107
en |
SINGLE DOSE OF TIOTROPIUM DOES NOT EFFECT HEART RATE VARIABILITY
Mehmet Unlu, Mehmet Melek, Fatma Fidan, Celal Kilit, Levent Tetik, Dayimi Kaya
Abstract
Aim:
Anticholinergic drugs may alter cardiac autonomic modulation. The aim of this study was to investigate the effects of inhaled tiotropium on heart rate variability (HRV).
Methods:
A randomized, double-blind, crossover design study was conducted on 11 healthy volunteers. Tiotropium or placebo was administered in two different testing sessions. Time domain parameters; mean R-R interval (mean-RR), the standard deviation of R-R interval (SDNN) and the root mean square of successive R-R interval differences (RMSSD) and power spectral analysis of HRV were assessed in the supine position, during handgrip exercise and controlled breathing before and after drug administration.
Results:
There were no statistically significant difference in baseline HRV parameters obtained before each drug administration (p >0.05). HRV parameters obtained after each drug administration were found not to be different during supine position, controlled breathing and handgrip exercise.
Conclusion:
Administration of single dose tiotropium did not effect cardiac autonomic modulations in healthy volunteers.
Keywords
Tiotropium, heart rate variability, healthy volunteer
|
|
© Copyright 2006 - Medical Investigations Society Alternative site location: http://www.ejgm.org
|
|