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Indian Journal of Human Genetics
Medknow Publications on behalf of Indian Society of Human Genetics
ISSN: 0971-6866
EISSN: 0971-6866
Vol. 9, No. 1, 2003, pp. 21-24
Bioline Code: hg03006
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Human Genetics, Vol. 9, No. 1, 2003, pp. 21-24

 en Radiation-induced chromosomal hot spots at G1 and G2 stages of human lymphocytes in culture
R. Murugesan


Radiation-induced chromosomal break points in cultured lymphocytes of normal healthy individuals as well as of those with certain genetic disorders are reported to be localized at certain specific loci (hot spots). These reports are based on studies carried out in lymphocytes irradiated at G1 stage. The present study examines whether the location of hot spots and the frequency seen in cells irradiated at G1 are similar to those irradiated at G2 stage of the cell cycle and also tests whether cells of patients exhibit hot spots on irradiation.The results showed that the radiation induced chromosomal break points to be similar in those irradiated are G1 and G2 stages of the cell cycle and also that cells of patients exhibited chromosomal hot spots.

Radiation, Break points, Hot spots

© Copyright 2003 - The Indian Society of Human Genetics
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