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Indian Journal of Human Genetics
Medknow Publications on behalf of Indian Society of Human Genetics
ISSN: 0971-6866
EISSN: 0971-6866
Vol. 14, No. 1, 2008, pp. 20-22
Bioline Code: hg08005
Full paper language: English
Document type: Case Report
Document available free of charge

Indian Journal of Human Genetics, Vol. 14, No. 1, 2008, pp. 20-22

 en A case of acute myeloid leukemia-M2 with trisomy 4 in addition to t(8;21)
Trivedi, PJ; Patel, PS; Brahmbhatt, MM; Patel, BP; Gajjar, SB; Iyer, RR; Parikh, EH; Shukla, SN; Shah, PM & Bakshi, SR


t(8;21)(q22;q22) is the most frequently observed karyotypic abnormality associated with acute myeloid leukemia (AML), specifically in FAB-M2. Short-term unstimulated bone marrow (BM) and peripheral blood lymphocyte culture showed 47,XX, +4,t(8;21) in all metaphase plates; and interphase and metaphase results of AML-ETO fusion was positive and trisomy of 4 was confirmed with WCP probes. Trisomy 4 in AML with t(8;21) is a rare numerical abnormality. Here we present such case of patient which may constitute a distinctive subtype.

Acute myeloid leukemia, cytogenetics, fluorescence in situ hybridization

© Copyright 2008 Indian Journal of Human Genetics.
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