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Indian Journal of Human Genetics
Medknow Publications on behalf of Indian Society of Human Genetics
ISSN: 0971-6866
EISSN: 1998-362x
Vol. 15, No. 1, 2009, pp. 19-22
Bioline Code: hg09005
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Human Genetics, Vol. 15, No. 1, 2009, pp. 19-22

 en Y-haplotypes and idiopathic male infertility in an Indian population
Singh, Kiran & Raman, Rajiva

Abstract

Infertility being a multifactorial disorder, both genetic and environmental factors contribute to the etiology of infertile phenotype. Chromosomal anomalies and Y-microdeletion are the established genetic risk factors of male infertility. Y-haplotypes has been found as risk factor for male infertility in certain populations, though in certain others no association has been reported, suggesting a population-specific association of these variations with male infertility. In a case-control study, 165 azoo-/oligospermic patients and 200 controls were haplotyped for certain Y-haplogroups for a possible association with idiopathic male infertility in an Indian population. Analysed Y-haplogroups showed no association with infertile phenotype. Thus this genetic factor is not a risk for infertility in the studied Indian population but that does not rule out the possibility of any of them, to be a risk in other populations.

Keywords
Male infertility, single nucleotide polymorphism, Y-haplotypes

 
© Copyright 2009 Indian Journal of Human Genetics.
Alternative site location: http://www.ijhg.com/

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